RGS1 explained

Regulator of G-protein signaling 1 is a protein that in humans is encoded by the RGS1 gene.^{[1] [2]}

This gene encodes a member of the regulator of G-protein signaling family. This protein is located on the cytosolic side of the plasma membrane and contains a conserved, 120 amino acid motif called the RGS domain. The protein attenuates the signalling activity of G-proteins by binding to activated, GTP-bound G alpha subunits and acting as a GTPase activating protein (GAP), increasing the rate of conversion of the GTP to GDP. This hydrolysis allows the G alpha subunits to bind G beta/gamma subunit heterodimers, forming inactive G-protein heterotrimers, thereby terminating the signal.^[3]

Further reading

• Hong JX, Wilson GL, Fox CH, Kehrl JH . Isolation and characterization of a novel B cell activation gene. . J. Immunol. . 150 . 9 . 3895–904 . 1993 . 10.4049/jimmunol.150.9.3895 . 8473738 . free .
• Heximer SP, Cristillo AD, Forsdyke DR . Comparison of mRNA expression of two regulators of G-protein signaling, RGS1/BL34/1R20 and RGS2/G0S8, in cultured human blood mononuclear cells. . DNA Cell Biol. . 16 . 5 . 589–98 . 1997 . 9174164 . 10.1089/dna.1997.16.589 .
• Bowman EP, Campbell JJ, Druey KM, etal . Regulation of chemotactic and proadhesive responses to chemoattractant receptors by RGS (regulator of G-protein signaling) family members. . J. Biol. Chem. . 273 . 43 . 28040–8 . 1998 . 9774420 . 10.1074/jbc.273.43.28040 . free .
• Denecke B, Meyerdierks A, Böttger EC . RGS1 is expressed in monocytes and acts as a GTPase-activating protein for G-protein-coupled chemoattractant receptors. . J. Biol. Chem. . 274 . 38 . 26860–8 . 1999 . 10480894 . 10.1074/jbc.274.38.26860 . free .
• John R. Falck . Popov SG, Krishna UM, Falck JR, Wilkie TM . Ca2+/Calmodulin reverses phosphatidylinositol 3,4, 5-trisphosphate-dependent inhibition of regulators of G protein-signaling GTPase-activating protein activity. . J. Biol. Chem. . 275 . 25 . 18962–8 . 2000 . 10747990 . 10.1074/jbc.M001128200 . free .
• Zheng B, Chen D, Farquhar MG . MIR16, a putative membrane glycerophosphodiester phosphodiesterase, interacts with RGS16 . Proc. Natl. Acad. Sci. U.S.A. . 97 . 8 . 3999–4004 . 2000 . 10760272 . 10.1073/pnas.97.8.3999 . 18131 . 2000PNAS...97.3999Z . free .
• Lou X, Yano H, Lee F, etal . GIPC and GAIP Form a Complex with TrkA: A Putative Link between G Protein and Receptor Tyrosine Kinase Pathways . Mol. Biol. Cell . 12 . 3 . 615–27 . 2001 . 11251075 . 10.1091/mbc.12.3.615. 30968 .
• Hoffmann M, Ward RJ, Cavalli A, etal . Differential capacities of the RGS1, RGS16 and RGS-GAIP regulators of G protein signaling to enhance alpha2A-adrenoreceptor agonist-stimulated GTPase activity of G(o1)alpha . J. Neurochem. . 78 . 4 . 797–806 . 2001 . 11520900 . 10.1046/j.1471-4159.2001.00479.x . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Le Y, Honczarenko M, Glodek AM, etal . CXC chemokine ligand 12-induced focal adhesion kinase activation and segregation into membrane domains is modulated by regulator of G protein signaling 1 in pro-B cells . J. Immunol. . 174 . 5 . 2582–90 . 2005 . 15728464 . 10.4049/jimmunol.174.5.2582. free .
• Han JI, Huang NN, Kim DU, Kehrl JH . RGS1 and RGS13 mRNA silencing in a human B lymphoma line enhances responsiveness to chemoattractants and impairs desensitization . J. Leukoc. Biol. . 79 . 6 . 1357–68 . 2006 . 16565322 . 10.1189/jlb.1105693 . 39672919 .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1 . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .

Notes and References

1. Newton JS, Deed RW, Mitchell EL, Murphy JJ, Norton JD . A B cell specific immediate early human gene is located on chromosome band 1q31 and encodes an alpha helical basic phosphoprotein . Biochim Biophys Acta . 1216 . 2 . 314–6 . Jan 1994 . 8241276 . 10.1016/0167-4781(93)90163-8.
2. Druey KM, Blumer KJ, Kang VH, Kehrl JH . Inhibition of G-protein-mediated MAP kinase activation by a new mammalian gene family . Nature . 379 . 6567 . 742–6 . May 1996 . 8602223 . 10.1038/379742a0 . 1996Natur.379..742D . 4362632 .
3. Web site: Entrez Gene: RGS1 regulator of G-protein signalling 1.