RGL2 explained

Ral guanine nucleotide dissociation stimulator-like 2 is a protein that in humans is encoded by the RGL2 gene.^{[1] [2]}

Interactions

RGL2 has been shown to interact with HRAS.^{[3] [4]}

Further reading

• Peterson SN, Trabalzini L, Brtva TR, Fischer T, Altschuler DL, Martelli P, Lapetina EG, Der CJ, White GC . Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1. . J. Biol. Chem. . 271 . 47 . 29903–8 . 1997 . 8939933 . 10.1074/jbc.271.47.29903 . free .
• Herberg JA, Sgouros J, Jones T, Copeman J, Humphray SJ, Sheer D, Cresswell P, Beck S, Trowsdale J . Genomic analysis of the Tapasin gene, located close to the TAP loci in the MHC. . Eur. J. Immunol. . 28 . 2 . 459–67 . 1998 . 9521053 . 10.1002/(SICI)1521-4141(199802)28:02<459::AID-IMMU459>3.0.CO;2-Z . 35772444 .
• Herberg JA, Beck S, Trowsdale J . TAPASIN, DAXX, RGL2, HKE2 and four new genes (BING 1, 3 to 5) form a dense cluster at the centromeric end of the MHC. . J. Mol. Biol. . 277 . 4 . 839–57 . 1998 . 9545376 . 10.1006/jmbi.1998.1637 .
• Ando A, Kikuti YY, Abe K, Shigenari A, Kawata H, Ikemura T, Kimura M, Inoko H . cDNA cloning, northern hybridization, and mapping analysis of a putative GDS-related protein gene at the centromeric ends of the human and mouse MHC regions. . Immunogenetics . 49 . 4 . 354–6 . 1999 . 10079301 . 10.1007/s002510050504 . 30077097 .
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R .
• Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ . Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization. . J. Biol. Chem. . 279 . 21 . 22353–61 . 2004 . 15031288 . 10.1074/jbc.M312867200 . free .
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . A human protein-protein interaction network: a resource for annotating the proteome. . Cell . 122 . 6 . 957–68 . 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .
• Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Isomura M, Okui K, Fujiwara T, Shin S, Nakamura Y . Isolation and mapping of RAB2L, a human cDNA that encodes a protein homologous to RalGDS . Cytogenet Cell Genet . 74 . 4 . 263–5 . January 1997 . 8976381 . 10.1159/000134431 .
2. Web site: Entrez Gene: RGL2 ral guanine nucleotide dissociation stimulator-like 2.
3. Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ . Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization . J. Biol. Chem. . 279 . 21 . 22353–61 . May 2004 . 15031288 . 10.1074/jbc.M312867200 . free .
4. Peterson SN, Trabalzini L, Brtva TR, Fischer T, Altschuler DL, Martelli P, Lapetina EG, Der CJ, White GC . Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1 . J. Biol. Chem. . 271 . 47 . 29903–8 . November 1996 . 8939933 . 10.1074/jbc.271.47.29903 . free .