RFX2 explained

DNA-binding protein RFX2 is a protein that in humans is encoded by the RFX2 gene.^{[1] [2]}

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites.

Further reading

• Reith W, Ucla C, Barras E, etal . RFX1, a transactivator of hepatitis B virus enhancer I, belongs to a novel family of homodimeric and heterodimeric DNA-binding proteins. . Mol. Cell. Biol. . 14 . 2 . 1230–44 . 1994 . 8289803 . 10.1128/MCB.14.2.1230. 358479 .
• Doyle J, Hoffman S, Ucla C, etal . Locations of human and mouse genes encoding the RFX1 and RFX2 transcription factor proteins. . Genomics . 35 . 1 . 227–30 . 1996 . 8661125 . 10.1006/geno.1996.0343 .
• Hillier LD, Lennon G, Becker M, etal . Generation and analysis of 280,000 human expressed sequence tags. . Genome Res. . 6 . 9 . 807–28 . 1997 . 8889549 . 10.1101/gr.6.9.807 . free .
• Iwama A, Pan J, Zhang P, etal . Dimeric RFX proteins contribute to the activity and lineage specificity of the interleukin-5 receptor alpha promoter through activation and repression domains. . Mol. Cell. Biol. . 19 . 6 . 3940–50 . 1999 . 10330134 . 10.1128/MCB.19.6.3940. 104353 .
• Morotomi-Yano K, Yano K, Saito H, etal . Human regulatory factor X 4 (RFX4) is a testis-specific dimeric DNA-binding protein that cooperates with other human RFX members. . J. Biol. Chem. . 277 . 1 . 836–42 . 2002 . 11682486 . 10.1074/jbc.M108638200 . free .
• Sengupta PK, Fargo J, Smith BD . The RFX family interacts at the collagen (COL1A2) start site and represses transcription. . J. Biol. Chem. . 277 . 28 . 24926–37 . 2002 . 11986307 . 10.1074/jbc.M111712200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Maijgren S, Sur I, Nilsson M, Toftgård R . Involvement of RFX proteins in transcriptional activation from a Ras-responsive enhancer element. . Arch. Dermatol. Res. . 295 . 11 . 482–9 . 2004 . 15024578 . 10.1007/s00403-004-0456-5 . 2408607 .
• Horvath GC, Kistler WS, Kistler MK . RFX2 is a potential transcriptional regulatory factor for histone H1t and other genes expressed during the meiotic phase of spermatogenesis. . Biol. Reprod. . 71 . 5 . 1551–9 . 2005 . 15229132 . 10.1095/biolreprod.104.032268 . free .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Pugliatti L, Derre J, Berger R, Ucla C, Reith W, Mach B . The genes for MHC class II regulatory factors RFX1 and RFX2 are located on the short arm of chromosome 19 . Genomics . 13 . 4 . 1307–10 . Sep 1992 . 1505960 . 10.1016/0888-7543(92)90052-T .
2. Web site: Entrez Gene: RFX2 regulatory factor X, 2 (influences HLA class II expression).