RFamide peptide family explained

The RFamide peptide family, or the RFamide-related peptides (RFRPs), are a family of neuropeptides.^{[1] [2]} They are characterized by the possession of an Arg-Phe-NH₂ motif at their C-terminal extremities.

Members of the family include:

• Neuropeptide FF group
  • Neuropeptide AF
  • Neuropeptide FF
  • Neuropeptide SF (RFRP-1)
  • Neuropeptide VF (RFRP-3) (GnIH - avian species)
• Prolactin-releasing peptide (PrRP)
• Pyroglutamylated RFamide peptide (QRFP)
• Kisspeptin (disputed)^[3]

See also

• Neuropeptide VF precursor
• FMRFamide

Notes and References

1. Book: Abba Kastin. Abba J. Kastin. Handbook of Biologically Active Peptides. 28 April 2011. Academic Press. 978-0-08-046379-7. 779–.
2. Findeisen. Maria. Rathmann. Daniel. Beck-Sickinger. Annette G.. RFamide Peptides: Structure, Function, Mechanisms and Pharmaceutical Potential. Pharmaceuticals. 4. 9. 2011. 1248–1280. 1424-8247. 10.3390/ph4091248. 4058657. free.
3. Yun S, Kim DK, Furlong M, Hwang JI, Vaudry H, Seong JY . Does Kisspeptin Belong to the Proposed RF-Amide Peptide Family? . Front Endocrinol (Lausanne) . 5 . 134 . 2014 . 25165463 . 4131245 . 10.3389/fendo.2014.00134 . free .