RERE explained

For other uses see RERE (disambiguation).

Arginine-glutamic acid dipeptide repeats protein is a protein that in humans is encoded by the RERE gene.^{[1] [2] [3]}

Function

This gene encodes a member of the atrophin family of arginine-glutamic acid (RE) dipeptide repeat-containing proteins. The encoded protein co-localizes with a transcription factor in the nucleus, and its overexpression triggers apoptosis. A similar protein in mouse associates with histone deacetylase and is thought to function as a transcriptional co-repressor during embryonic development. Recent reports also indicate that RERE and its Drosophila homolog associate with histone methyltransferases in regulating gene expression. Multiple transcript variants encoding different isoforms have been found for this gene.

Interactions

RERE has been shown to interact with ATN1.

Further reading

• Wang L, Rajan H, Pitman JL, McKeown M, Tsai CC . Histone deacetylase-associating Atrophin proteins are nuclear receptor corepressors . Genes & Development . 20 . 5 . 525–30 . Mar 2006 . 16481466 . 1410805 . 10.1101/gad.1393506 .
• Wang L, Charroux B, Kerridge S, Tsai CC . Atrophin recruits HDAC1/2 and G9a to modify histone H3K9 and to determine cell fates . EMBO Reports . 9 . 6 . 555–62 . Jun 2008 . 18451879 . 2427389 . 10.1038/embor.2008.67 .
• Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O . Characterization of cDNA clones in size-fractionated cDNA libraries from human brain . DNA Research . 4 . 5 . 345–9 . Oct 1997 . 9455484 . 10.1093/dnares/4.5.345 . free .
• Waerner T, Gardellin P, Pfizenmaier K, Weith A, Kraut N . Human RERE is localized to nuclear promyelocytic leukemia oncogenic domains and enhances apoptosis . Cell Growth & Differentiation . 12 . 4 . 201–10 . Apr 2001 . 11331249 .
• Yi J, Kloeker S, Jensen CC, Bockholt S, Honda H, Hirai H, Beckerle MC . Members of the Zyxin family of LIM proteins interact with members of the p130Cas family of signal transducers . The Journal of Biological Chemistry . 277 . 11 . 9580–9 . Mar 2002 . 11782456 . 10.1074/jbc.M106922200 . free .
• Wistow G, Bernstein SL, Wyatt MK, Behal A, Touchman JW, Bouffard G, Smith D, Peterson K . Expressed sequence tag analysis of adult human lens for the NEIBank Project: over 2000 non-redundant transcripts, novel genes and splice variants . Molecular Vision . 8 . 171–84 . Jun 2002 . 12107413 .
• Tomarev SI, Wistow G, Raymond V, Dubois S, Malyukova I . Gene expression profile of the human trabecular meshwork: NEIBank sequence tag analysis . Investigative Ophthalmology & Visual Science . 44 . 6 . 2588–96 . Jun 2003 . 12766061 . 10.1167/iovs.02-1099 . free .
• Zoltewicz JS, Stewart NJ, Leung R, Peterson AS . Atrophin 2 recruits histone deacetylase and is required for the function of multiple signaling centers during mouse embryogenesis . Development . 131 . 1 . 3–14 . Jan 2004 . 14645126 . 10.1242/dev.00908 . 20498980 . free .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–5 . Aug 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Otsuki T, Ota T, Nishikawa T, Hayashi K, Suzuki Y, Yamamoto J, Wakamatsu A, Kimura K, Sakamoto K, Hatano N, Kawai Y, Ishii S, Saito K, Kojima S, Sugiyama T, Ono T, Okano K, Yoshikawa Y, Aotsuka S, Sasaki N, Hattori A, Okumura K, Nagai K, Sugano S, Isogai T . Signal sequence and keyword trap in silico for selection of full-length human cDNAs encoding secretion or membrane proteins from oligo-capped cDNA libraries . DNA Research . 12 . 2 . 117–26 . 2007 . 16303743 . 10.1093/dnares/12.2.117 . free .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . Jan 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Lim J, Hao T, Shaw C, Patel AJ, Szabó G, Rual JF, Fisk CJ, Li N, Smolyar A, Hill DE, Barabási AL, Vidal M, Zoghbi HY . A protein-protein interaction network for human inherited ataxias and disorders of Purkinje cell degeneration . Cell . 125 . 4 . 801–14 . May 2006 . 16713569 . 10.1016/j.cell.2006.03.032 . 13709685 . free .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . Nov 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Yanagisawa H, Bundo M, Miyashita T, Okamura-Oho Y, Tadokoro K, Tokunaga K, Yamada M . Protein binding of a DRPLA family through arginine-glutamic acid dipeptide repeats is enhanced by extended polyglutamine . Human Molecular Genetics . 9 . 9 . 1433–42 . May 2000 . 10814707 . 10.1093/hmg/9.9.1433 . free .
2. Amler LC, Bauer A, Corvi R, Dihlmann S, Praml C, Cavenee WK, Schwab M, Hampton GM . Identification and characterization of novel genes located at the t(1;15)(p36.2;q24) translocation breakpoint in the neuroblastoma cell line NGP . Genomics . 64 . 2 . 195–202 . Mar 2000 . 10729226 . 10.1006/geno.1999.6097 .
3. Web site: Entrez Gene: RERE arginine-glutamic acid dipeptide (RE) repeats.