REEP2 explained

Receptor expression-enhancing protein 2 is a protein that in humans is encoded by the REEP2 gene.^{[1] [2]}

Function

The protein encoded by REEP2 belongs to a family of proteins with receptor enhancing expression capabilities, including possible enhancement of G protein-coupled receptors.^[3] The REEP2 protein shows a restricted mode of expression in human tissues.^[4]

Clinical significance

REEP2 mutations have been reported in families with hereditary spastic paraplegia.^[5]

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . January 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA . A "double adaptor" method for improved shotgun library construction . Analytical Biochemistry . 236 . 1 . 107–13 . April 1996 . 8619474 . 10.1006/abio.1996.0138 .
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA . Large-scale concatenation cDNA sequencing . Genome Research . 7 . 4 . 353–8 . April 1997 . 9110174 . 139146 . 10.1101/gr.7.4.353 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . October 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Lai F, Godley LA, Joslin J, Fernald AA, Liu J, Espinosa R, Zhao N, Pamintuan L, Till BG, Larson RA, Qian Z, Le Beau MM . Transcript map and comparative analysis of the 1.5-Mb commonly deleted segment of human 5q31 in malignant myeloid diseases with a del(5q) . Genomics . 71 . 2 . 235–45 . January 2001 . 11161817 . 10.1006/geno.2000.6414 .

Notes and References

1. Clark. Adrian J.L.. Metherell. Louise A.. Cheetham. Michael E.. Huebner. Angela. Inherited ACTH insensitivity illuminates the mechanisms of ACTH action. Trends in Endocrinology & Metabolism. 16. 10. 451–457. 10.1016/j.tem.2005.10.006. 16271481. 2005. 27450434.
2. Saito. Harumi. Kubota. Momoka. Roberts. Richard W.. Chi. Qiuyi. Matsunami. Hiroaki. RTP Family Members Induce Functional Expression of Mammalian Odorant Receptors. Cell. 119. 5. 679–691. 10.1016/j.cell.2004.11.021. 2004. 15550249. 13555927. free.
3. Björk. Susann. Hurt. Carl M.. Ho. Vincent K.. Angelotti. Timothy. 2013-12-17. Correction: REEPs Are Membrane Shaping Adapter Proteins That Modulate Specific G Protein-Coupled Receptor Trafficking by Affecting ER Cargo Capacity. PLOS ONE. 8. 12. 10.1371/annotation/6f86410c-63c3-4fcd-b1cb-9fd8d2ea95d0. 10.1371/annotation/6f86410c-63c3-4fcd-b1cb-9fd8d2ea95d0. 1932-6203. 3867549 . free .
4. Uhlén. Mathias. Fagerberg. Linn. Hallström. Björn M.. Lindskog. Cecilia. Oksvold. Per. Mardinoglu. Adil. Sivertsson. Åsa. Kampf. Caroline. Sjöstedt. Evelina. 2015-01-23. Tissue-based map of the human proteome. Science. en. 347. 6220. 1260419. 10.1126/science.1260419. 0036-8075. 25613900. 802377.
5. Esteves. Typhaine. Durr. Alexandra. Mundwiller. Emeline. Loureiro. José L.. Boutry. Maxime. Gonzalez. Michael A.. Gauthier. Julie. El-Hachimi. Khalid H.. Depienne. Christel. Loss of Association of REEP2 with Membranes Leads to Hereditary Spastic Paraplegia. The American Journal of Human Genetics. 94. 2. 268–277. 10.1016/j.ajhg.2013.12.005. 24388663. 3928657. 2014.