RECQL5 explained

ATP-dependent DNA helicase Q5 is an enzyme that in humans is encoded by the RECQL5 gene.^{[1] [2]}

Interactions

RECQL5 has been shown to interact with EEF1G.^[3]

Further reading

• Sekelsky JJ, Brodsky MH, Rubin GM, Hawley RS . Drosophila and human RecQ5 exist in different isoforms generated by alternative splicing . Nucleic Acids Research . 27 . 18 . 3762–9 . Sep 1999 . 10471747 . 148633 . 10.1093/nar/27.18.3762 .
• Shimamoto A, Nishikawa K, Kitao S, Furuichi Y . Human RecQ5beta, a large isomer of RecQ5 DNA helicase, localizes in the nucleoplasm and interacts with topoisomerases 3alpha and 3beta . Nucleic Acids Research . 28 . 7 . 1647–55 . Apr 2000 . 10710432 . 102787 . 10.1093/nar/28.7.1647 .
• Garcia PL, Liu Y, Jiricny J, West SC, Janscak P . Human RECQ5beta, a protein with DNA helicase and strand-annealing activities in a single polypeptide . The EMBO Journal . 23 . 14 . 2882–91 . Jul 2004 . 15241474 . 514958 . 10.1038/sj.emboj.7600301 .
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . Sep 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .
• Hu Y, Lu X, Barnes E, Yan M, Lou H, Luo G . Recql5 and Blm RecQ DNA helicases have nonredundant roles in suppressing crossovers . Molecular and Cellular Biology . 25 . 9 . 3431–42 . May 2005 . 15831450 . 1084310 . 10.1128/MCB.25.9.3431-3442.2005 .
• Kimura K, Wakamatsu A, Suzuki Y, Ota T, Nishikawa T, Yamashita R, Yamamoto J, Sekine M, Tsuritani K, Wakaguri H, Ishii S, Sugiyama T, Saito K, Isono Y, Irie R, Kushida N, Yoneyama T, Otsuka R, Kanda K, Yokoi T, Kondo H, Wagatsuma M, Murakawa K, Ishida S, Ishibashi T, Takahashi-Fujii A, Tanase T, Nagai K, Kikuchi H, Nakai K, Isogai T, Sugano S . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Research . 16 . 1 . 55–65 . Jan 2006 . 16344560 . 1356129 . 10.1101/gr.4039406 .
• Kanagaraj R, Saydam N, Garcia PL, Zheng L, Janscak P . Human RECQ5beta helicase promotes strand exchange on synthetic DNA structures resembling a stalled replication fork . Nucleic Acids Research . 34 . 18 . 5217–31 . 2006 . 17003056 . 1635296 . 10.1093/nar/gkl677 .
• Hu Y, Raynard S, Sehorn MG, Lu X, Bussen W, Zheng L, Stark JM, Barnes EL, Chi P, Janscak P, Jasin M, Vogel H, Sung P, Luo G . RECQL5/Recql5 helicase regulates homologous recombination and suppresses tumor formation via disruption of Rad51 presynaptic filaments . Genes & Development . 21 . 23 . 3073–84 . Dec 2007 . 18003859 . 2081974 . 10.1101/gad.1609107 .

Notes and References

1. Kitao S, Ohsugi I, Ichikawa K, Goto M, Furuichi Y, Shimamoto A . Cloning of two new human helicase genes of the RecQ family: biological significance of multiple species in higher eukaryotes . Genomics . 54 . 3 . 443–52 . Dec 1998 . 9878247 . 10.1006/geno.1998.5595 .
2. Web site: Entrez Gene: RECQL5 RecQ protein-like 5.
3. Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . Sep 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .