RDS-127 explained

RDS-127 is a drug which is used in scientific research. It acts as a D₂-like receptor agonist^[1] and also has some serotonin and adrenergic agonist effects,^{[2] [3] [4] [5]} as well as some anticholinergic action,^{[6] [7]} and produces both anorectic and pro-sexual effects in animal studies.^{[8] [9]}

See also

• Bay R 1531
• UH-232

Notes and References

1. Arnerić SP, Long JP, Williams M, etal . RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane): central effects of a new dopamine receptor agonist . The Journal of Pharmacology and Experimental Therapeutics . 224 . 1 . 161–70 . January 1983 . 6401334 .
2. Arnerić SP, Roetker A, Long JP, Mott J, Barfknecht CF . Effects of semirigid methoxamine analogs on vascular smooth muscle: studies of methoxy-2-aminotetralin and 2-aminoindane derivatives . Archives Internationales de Pharmacodynamie et de Thérapie . 257 . 2 . 263–73 . June 1982 . 7114973 .
3. Arnerić SP, Long JP . Evidence that a novel dopamine receptor agonist, RDS-127 [2-di-n-propylamino-4,7-dimethoxyindane] has some centrally mediated cardiovascular actions . The Journal of Pharmacy and Pharmacology . 36 . 5 . 318–21 . May 1984 . 6145768 . 10.1111/j.2042-7158.1984.tb04382.x. 24354158 .
4. Clark JT, Smith ER . Failure of pimozide and metergoline to antagonize the RDS-127-induced facilitation of ejaculatory behavior . Physiology & Behavior . 37 . 1 . 47–52 . 1986 . 3737722 . 10.1016/0031-9384(86)90382-3. 24423685 .
5. Rezaki YE, Ilhan M . Evaluation of alpha-adrenoceptor agonistic activity of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in rabbit and rat aortae . Archives Internationales de Pharmacodynamie et de Thérapie . 310 . 76–86 . 1991 . 1685313 .
6. Sahin I, Ilhan M . The antimuscarinic activity of a dopamine receptor agonist (RDS-127) differentiates M2-muscarinic receptors of heart, ileum and trachea in guinea-pig . Archives Internationales de Pharmacodynamie et de Thérapie . 296 . 163–72 . 1988 . 2907277 .
7. Sahin I, Tuncer M, Ilhan M . Dopamine receptor agonists, N,N-dipropyl-2-aminotetralin (TL-68) and 2-di-n-propylamino-4,7-dimethoxyindane (RDS-127) antagonize oxotremorine-induced tremors by antimuscarinic action in mice . Archives Internationales de Physiologie et de Biochimie . 98 . 1 . 7–9 . March 1990 . 1692697 . 10.3109/13813459009115730.
8. Arnerić SP, Roetker A, Long JP . Potent anorexic-like effects of RDS-127 (2-di-n-propylamino-4,7-dimethoxyindane) in the rat: a comparison with other dopamine-receptor agonists . Neuropharmacology . 21 . 9 . 885–90 . September 1982 . 6897285 . 10.1016/0028-3908(82)90080-6. 12005863 .
9. Kwong LL, Smith ER, Davidson JM, Peroutka SJ . Differential interactions of "prosexual" drugs with 5-hydroxytryptamine1A and alpha 2-adrenergic receptors . Behavioral Neuroscience . 100 . 5 . 664–8 . October 1986 . 2877677 . 10.1037/0735-7044.100.5.664.