RDH8 explained

Retinol dehydrogenase 8 is an enzyme that in humans is encoded by the RDH8 gene.^{[1] [2] [3]}

All-trans-retinol dehydrogenase (RDH8) is a visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol in the presence of NADPH. It is a member of the short chain dehydrogenase/reductase family and is located in the outer segments of the photoreceptor cells; hence it is also known as photoreceptor retinol dehydrogenase. It is important in the visual cycle by beginning the rhodopsin regeneration pathway by reducing all-trans-retinal, the product of bleached and hydrolysed rhodopsin.^[4] This is a rate-limiting step in the visual cycle.^[5] [supplied by OMIM]

Further reading

• Maeda A . Role of photoreceptor-specific retinol dehydrogenase in the retinoid cycle in vivo . J. Biol. Chem. . 280 . 19 . 18822–18832 . 2005 . 15755727 . 10.1074/jbc.M501757200 . 1283069 . Maeda T . Imanishi Y . Kuksa . V . Alekseev . A . Bronson . JD . Zhang . H . Zhu . L . Sun . W . free .
• Perrault I . Retinal dehydrogenase 12 (RDH12) mutations in leber congenital amaurosis . Am. J. Hum. Genet. . 75 . 4 . 639–646 . 2004 . 15322982 . 10.1086/424889 . 1182050 . Hanein S . Gerber S . Barbet . F . Ducroq . D . Dollfus . H . Hamel . C . Dufier . J . Munnich . A .
• Luo W, Marsh-Armstrong N, Rattner A, Nathans J . An outer segment localization signal at the C terminus of the photoreceptor-specific retinol dehydrogenase . J. Neurosci. . 24 . 11 . 2623–2632 . 2004 . 15028754 . 10.1523/JNEUROSCI.5302-03.2004 . 6729528 . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . Suzuki Y . Nishikawa T . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Haeseleer F . Dual-substrate specificity short chain retinol dehydrogenases from the vertebrate retina . J. Biol. Chem. . 277 . 47 . 45537–45546 . 2003 . 12226107 . 10.1074/jbc.M208882200 . 1435693 . Jang GF . Imanishi Y . Driessen . CA . Matsumura . M . Nelson . PS . Palczewski . K . free .

Notes and References

1. Rattner A, Smallwood PM, Nathans J . Identification and characterization of all-trans-retinol dehydrogenase from photoreceptor outer segments, the visual cycle enzyme that reduces all-trans-retinal to all-trans-retinol . J Biol Chem . 275 . 15 . 11034–11043 . May 2000 . 10753906 . 10.1074/jbc.275.15.11034 . free .
2. Persson B, Kallberg Y, Bray JE, Bruford E, Dellaporta SL, Favia AD, Duarte RG, Jornvall H, Kavanagh KL, Kedishvili N, Kisiela M, Maser E, Mindnich R, Orchard S, Penning TM, Thornton JM, Adamski J, Oppermann U . The SDR (short-chain dehydrogenase/reductase and related enzymes) nomenclature initiative . Chem Biol Interact . 178 . 1–3 . 94–98 . Feb 2009 . 19027726 . 2896744. 10.1016/j.cbi.2008.10.040 . 2009CBI...178...94P .
3. Web site: Entrez Gene: RDH8 retinol dehydrogenase 8 (all-trans).
4. Rando RR . The biochemistry of the visual cycle . Chem. Rev. . 101 . 7 . 1881–1896 . 2001 . 11710234 . 10.1021/cr960141c.
5. Saari JC, Garwin GG, Van Hooser JP, Palczewski K . Reduction of all-trans-retinal limits regeneration of visual pigment in mice . Vision Res. . 38 . 10 . 1325–1333 . 1998 . 9667000 . 10.1016/S0042-6989(97)00198-3 . 16267177 .