RCOR1 explained

REST corepressor 1 also known as CoREST is a protein that in humans is encoded by the RCOR1 gene.^{[1] [2]}

Function

This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor).^[2]

Interactions

RCOR1 has been shown to interact with

• HDAC1,^[3]
• HDAC2,^[3]
• HMG20B,^[4]
• REST and
• PHF21A.^{[4] [5]}

References

Further reading

• Nomura N, Nagase T, Miyajima N, Sazuka T, Tanaka A, Sato S, Seki N, Kawarabayasi Y, Ishikawa K, Tabata S . Prediction of the coding sequences of unidentified human genes. II. The coding sequences of 40 new genes (KIAA0041-KIAA0080) deduced by analysis of cDNA clones from human cell line KG-1 . DNA Res. . 1 . 5 . 223–9 . 1994 . 7584044 . 10.1093/dnares/1.5.223 . free .
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA . A "double adaptor" method for improved shotgun library construction . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 .
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA . Large-scale concatenation cDNA sequencing . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 139146 . 10.1101/gr.7.4.353 .
• Grimes JA, Nielsen SJ, Battaglioli E, Miska EA, Speh JC, Berry DL, Atouf F, Holdener BC, Mandel G, Kouzarides T . The co-repressor mSin3A is a functional component of the REST-CoREST repressor complex . J. Biol. Chem. . 275 . 13 . 9461–7 . 2000 . 10734093 . 10.1074/jbc.275.13.9461 . free .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Res. . 10 . 11 . 1788–95 . 2000 . 11076863 . 310948 . 10.1101/gr.143000 .
• Humphrey GW, Wang Y, Russanova VR, Hirai T, Qin J, Nakatani Y, Howard BH . Stable histone deacetylase complexes distinguished by the presence of SANT domain proteins CoREST/kiaa0071 and Mta-L1 . J. Biol. Chem. . 276 . 9 . 6817–24 . 2001 . 11102443 . 10.1074/jbc.M007372200 . free .
• You A, Tong JK, Grozinger CM, Schreiber SL . CoREST is an integral component of the CoREST- human histone deacetylase complex . Proc. Natl. Acad. Sci. U.S.A. . 98 . 4 . 1454–8 . 2001 . 11171972 . 29278 . 10.1073/pnas.98.4.1454 . 2001PNAS...98.1454Y . free .
• Ballas N, Battaglioli E, Atouf F, Andres ME, Chenoweth J, Anderson ME, Burger C, Moniwa M, Davie JR, Bowers WJ, Federoff HJ, Rose DW, Rosenfeld MG, Brehm P, Mandel G . Regulation of neuronal traits by a novel transcriptional complex . Neuron . 31 . 3 . 353–65 . 2001 . 11516394 . 10.1016/S0896-6273(01)00371-3 . free .
• Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R . A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes . Proc. Natl. Acad. Sci. U.S.A. . 99 . 11 . 7420–5 . 2002 . 12032298 . 124246 . 10.1073/pnas.112008599 . 2002PNAS...99.7420H . free .
• Battaglioli E, Andrés ME, Rose DW, Chenoweth JG, Rosenfeld MG, Anderson ME, Mandel G . REST repression of neuronal genes requires components of the hSWI.SNF complex . J. Biol. Chem. . 277 . 43 . 41038–45 . 2002 . 12192000 . 10.1074/jbc.M205691200 . free .
• Lunyak VV, Burgess R, Prefontaine GG, Nelson C, Sze SH, Chenoweth J, Schwartz P, Pevzner PA, Glass C, Mandel G, Rosenfeld MG . Corepressor-dependent silencing of chromosomal regions encoding neuronal genes . Science . 298 . 5599 . 1747–52 . 2002 . 12399542 . 10.1126/science.1076469 . 2002Sci...298.1747L . 10.1.1.136.7131 . 13507921 .
• Hakimi MA, Dong Y, Lane WS, Speicher DW, Shiekhattar R . A candidate X-linked mental retardation gene is a component of a new family of histone deacetylase-containing complexes . J. Biol. Chem. . 278 . 9 . 7234–9 . 2003 . 12493763 . 10.1074/jbc.M208992200 . free.
• Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T . Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression . Biochem. Biophys. Res. Commun. . 322 . 2 . 601–8 . 2004 . 15325272 . 10.1016/j.bbrc.2004.07.163 .
• Gu H, Liang Y, Mandel G, Roizman B . Components of the REST/CoREST/histone deacetylase repressor complex are disrupted, modified, and translocated in HSV-1-infected cells . Proc. Natl. Acad. Sci. U.S.A. . 102 . 21 . 7571–6 . 2005 . 15897453 . 1140450 . 10.1073/pnas.0502658102 . 2005PNAS..102.7571G . free .
• Lee MG, Wynder C, Cooch N, Shiekhattar R . An essential role for CoREST in nucleosomal histone 3 lysine 4 demethylation . Nature . 437 . 7057 . 432–5 . 2005 . 16079794 . 10.1038/nature04021 . 2005Natur.437..432L . 4396351 .
• Shi YJ, Matson C, Lan F, Iwase S, Baba T, Shi Y . Regulation of LSD1 histone demethylase activity by its associated factors . Mol. Cell . 19 . 6 . 857–64 . 2005 . 16140033 . 10.1016/j.molcel.2005.08.027 . free .
• Nousiainen M, Silljé HH, Sauer G, Nigg EA, Körner R . Phosphoproteome analysis of the human mitotic spindle . Proc. Natl. Acad. Sci. U.S.A. . 103 . 14 . 5391–6 . 2006 . 16565220 . 1459365 . 10.1073/pnas.0507066103 . 2006PNAS..103.5391N . free .

Notes and References

1. Andrés ME, Burger C, Peral-Rubio MJ, Battaglioli E, Anderson ME, Grimes J, Dallman J, Ballas N, Mandel G . CoREST: a functional corepressor required for regulation of neural-specific gene expression . Proc. Natl. Acad. Sci. U.S.A. . 96 . 17 . 9873–8 . September 1999 . 10449787 . 22303 . 10.1073/pnas.96.17.9873 . 1999PNAS...96.9873A . free .
2. Web site: Entrez Gene: RCOR1 REST corepressor 1.
3. You A, Tong JK, Grozinger CM, Schreiber SL . CoREST is an integral component of the CoREST- human histone deacetylase complex . Proc. Natl. Acad. Sci. U.S.A. . 98 . 4 . 1454–8 . February 2001 . 11171972 . 29278 . 10.1073/pnas.98.4.1454 . 2001PNAS...98.1454Y . free .
4. Hakimi MA, Bochar DA, Chenoweth J, Lane WS, Mandel G, Shiekhattar R . A core-BRAF35 complex containing histone deacetylase mediates repression of neuronal-specific genes . Proc. Natl. Acad. Sci. U.S.A. . 99 . 11 . 7420–5 . May 2002 . 12032298 . 124246 . 10.1073/pnas.112008599 . 2002PNAS...99.7420H . free .
5. Iwase S, Januma A, Miyamoto K, Shono N, Honda A, Yanagisawa J, Baba T . Characterization of BHC80 in BRAF-HDAC complex, involved in neuron-specific gene repression . Biochem. Biophys. Res. Commun. . 322 . 2 . 601–8 . September 2004 . 15325272 . 10.1016/j.bbrc.2004.07.163 .