RCC2 explained

Protein RCC2 also known as telophase disk protein of 60 kDa (TD-60) or RCC1-like protein TD-60 is a protein that in humans is encoded by the RCC2 gene.^{[1] [2] [3]}

Function

RCC2 has structural similarity to RCC1, and has been shown to have weak guanine nucleotide exchange factor (GEF) activity on the small GTPase Rac.^[2] TD-60 has also been shown to interact with the Chromosomal Passenger Complex (CPC), and to activate the catalytic component of the CPC, Aurora B, in the presence of microtubules.^{[4] [5]}

Further reading

• Andreassen PR, Palmer DK, Wener MH, Margolis RL . Telophase disc: a new mammalian mitotic organelle that bisects telophase cells with a possible function in cytokinesis. . J. Cell Sci. . 99 . 3. 523–34 . 1991 . 10.1242/jcs.99.3.523 . 1939370 . free .
• Martineau SN, Andreassen PR, Margolis RL . Delay of HeLa cell cleavage into interphase using dihydrocytochalasin B: retention of a postmitotic spindle and telophase disc correlates with synchronous cleavage recovery. . J. Cell Biol. . 131 . 1 . 191–205 . 1995 . 7559776 . 10.1083/jcb.131.1.191 . 2120587 .
• Martineau-Thuillier S, Andreassen PR, Margolis RL . Colocalization of TD-60 and INCENP throughout G2 and mitosis: evidence for their possible interaction in signalling cytokinesis. . Chromosoma . 107 . 6–7 . 461–70 . 1999 . 9914378 . 10.1007/s004120050330 . 24935187 .
• Scherl A, Couté Y, Déon C, etal . Functional proteomic analysis of human nucleolus . Mol. Biol. Cell . 13 . 11 . 4100–9 . 2003 . 12429849 . 10.1091/mbc.E02-05-0271 . 133617 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gassmann R, Carvalho A, Henzing AJ, etal . Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle . J. Cell Biol. . 166 . 2 . 179–91 . 2004 . 15249581 . 10.1083/jcb.200404001 . 2172304 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Rosasco-Nitcher. Sara. Lan W . Khorasanizadeh S . Stukenberg PT. . Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation. Science. January 2008. 319. 469–472. 10.1126/science.1148980. 18218899. 5862. 2008Sci...319..469R. 10374348.

Notes and References

1. Nagase T, Kikuno R, Ishikawa K, Hirosawa M, Ohara O . Prediction of the coding sequences of unidentified human genes. XVII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res . 7 . 2 . 143–50 . Sep 2000 . 10819331 . 10.1093/dnares/7.2.143 . free .
2. Mollinari C, Reynaud C, Martineau-Thuillier S, Monier S, Kieffer S, Garin J, Andreassen PR, Boulet A, Goud B, Kleman JP, Margolis RL . The mammalian passenger protein TD-60 is an RCC1 family member with an essential role in prometaphase to metaphase progression . Dev Cell . 5 . 2 . 295–307 . Aug 2003 . 12919680 . 10.1016/S1534-5807(03)00205-3 . free .
3. Web site: Entrez Gene: RCC2 regulator of chromosome condensation 2.
4. Gassmann R, Carvalho A, Henzing AJ, Ruchaud S, Hudson DF, Honda R, Nigg EA, Gerloff DL, Earnshaw WC . Borealin: a novel chromosomal passenger required for stability of the bipolar mitotic spindle . J. Cell Biol. . 166 . 2 . 179–91 . July 2004 . 15249581 . 2172304 . 10.1083/jcb.200404001 .
5. Rosasco-Nitcher SE, Lan W, Khorasanizadeh S, Stukenberg PT . Centromeric Aurora-B activation requires TD-60, microtubules, and substrate priming phosphorylation . Science . 319 . 5862 . 469–72 . January 2008 . 18218899 . 10.1126/science.1148980 . 2008Sci...319..469R . 10374348 .