RCBTB2 explained

RCC1 and BTB domain-containing protein 2 is a protein that in humans is encoded by the RCBTB2 gene.^{[1] [2]}

This gene encodes a member of the RCC1-related GEF family. The N-terminal half of the encoded amino acid sequence shows similarity to the regulator of chromosome condensation RCC1, which acts as a guanine nucleotide exchange factor (GEF) protein for the Ras-related GTPase Ran.

Further reading

• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . Venkatesan K . Hao T . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Dunham A . The DNA sequence and analysis of human chromosome 13 . Nature . 428 . 6982 . 522–8 . 2004 . 15057823 . 10.1038/nature02379 . 2665288 . Matthews LH . Burton J . Ashurst . J. L. . Howe . K. L. . Ashcroft . K. J. . Beare . D. M. . Burford . D. C. . Hunt . S. E. . 2004Natur.428..522D .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . Suzuki Y . Nishikawa T . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Latil A . CHC1-L, a candidate gene for prostate carcinogenesis at 13q14.2, is frequently affected by loss of heterozygosity and underexpressed in human prostate cancer . Int. J. Cancer . 99 . 5 . 689–96 . 2002 . 12115502 . 10.1002/ijc.10393 . Morant P . Fournier G . Mangin . Philippe . Berthon . Philippe . Cussenot . Olivier . 36595791 . free.
• Renault L . Crystallization and preliminary X-ray analysis of human RCC1, the regulator of chromosome condensation . Acta Crystallogr. D . 55 . Pt 1 . 272–5 . 1999 . 10089422 . 10.1107/S0907444998007768 . Nassar N . Wittinghofer A . Roth . Michel . Vetter . Ingrid R. . 1999AcCrD..55..272R .

Notes and References

1. Devilder MC, Cadoret E, Cherel M, Moreau I, Rondeau G, Bezieau S, Moisan JP . cDNA cloning, gene characterization and 13q14.3 chromosomal assignment of CHC1-L, a chromosome condensation regulator-like guanine nucleotide exchange factor . Genomics . 54 . 1 . 99–106 . Jan 1999 . 9806834 . 10.1006/geno.1998.5498 .
2. Web site: Entrez Gene: RCBTB2 regulator of chromosome condensation (RCC1) and BTB (POZ) domain containing protein 2.