RCAN3 explained

RCAN3 is a gene that in humans encodes the Calcipressin-3 protein. Calcipressin-3 is a protein that in humans is encoded by the RCAN3 gene and is a member of the Calcipressin family of proteins.^{[1] [2]}

Expression

RCAN3 is highly expressed in the Cerebellar Hemisphere, Prostrate, and the Mucosa of the esophagus.^[3]

Orthologs

RCAN3 was present in the common ancestor of all animals. As a result, orthologs are present in other species, including mice (Rcan3), chickens (RCAN3), and zebrafish (rcan3).^[4]

Clinical Significance

Calcipressin-3, along with the other two Calcipressin proteins have been identified as possible contributing factors to Down Syndrome in humans.^[5]

Summary box

N/A

See also

• • RCAN1 RCAN2

Further reading

• Facchin F, Canaider S, Vitale L, etal . Identification and analysis of human RCAN3 (DSCR1L2) mRNA and protein isoforms. . Gene . 407 . 1–2 . 159–68 . 2008 . 18022329 . 10.1016/j.gene.2007.10.006 .
• Mulero MC, Aubareda A, Schlüter A, Pérez-Riba M . RCAN3, a novel calcineurin inhibitor that down-regulates NFAT-dependent cytokine gene expression. . Biochim. Biophys. Acta . 1773 . 3 . 330–41 . 2007 . 17270291 . 10.1016/j.bbamcr.2006.12.007 . free .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .
• Canaider S, Facchin F, Griffoni C, etal . Proteins encoded by human Down syndrome critical region gene 1-like 2 (DSCR1L2) mRNA and by a novel DSCR1L2 mRNA isoform interact with cardiac troponin I (TNNI3). . Gene . 372 . 128–36 . 2006 . 16516408 . 10.1016/j.gene.2005.12.029 . 11586/196835 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .

Notes and References

1. Strippoli P, Lenzi L, Petrini M, Carinci P, Zannotti M . A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2) . Genomics . 64 . 3 . 252–63 . May 2000 . 10756093 . 10.1006/geno.2000.6127 .
2. Web site: Entrez Gene: DSCR1L2 Down syndrome critical region gene 1-like 2.
3. Web site: Gene Expression in 53 tissues from GTEx RNA-seq of 8555 samples (570 donors) (RCAN3). 2020-06-11. genome.ucsc.edu.
4. Web site: RCAN3 Gene - GeneCards RCAN3 Protein RCAN3 Antibody. 2020-06-11. www.genecards.org.
5. Web site: InterPro. 2020-06-11. www.ebi.ac.uk.