RCAN2 explained

RCAN2 is a gene that in humans encodes for the protein Calcipressin-2.

Calcipressin-2 is a protein that in humans is encoded by the RCAN2 gene.^{[1] [2]}

Summary box

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See also

• • RCAN1 RCAN3

Further reading

• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Rothermel B, Vega RB, Yang J, etal . A protein encoded within the Down syndrome critical region is enriched in striated muscles and inhibits calcineurin signaling. . J. Biol. Chem. . 275 . 12 . 8719–25 . 2000 . 10722714 . 10.1074/jbc.275.12.8719 . free .
• Strippoli P, Lenzi L, Petrini M, etal . A new gene family including DSCR1 (Down Syndrome Candidate Region 1) and ZAKI-4: characterization from yeast to human and identification of DSCR1-like 2, a novel human member (DSCR1L2). . Genomics . 64 . 3 . 252–63 . 2000 . 10756093 . 10.1006/geno.2000.6127 .
• Fuentes JJ, Genescà L, Kingsbury TJ, etal . DSCR1, overexpressed in Down syndrome, is an inhibitor of calcineurin-mediated signaling pathways. . Hum. Mol. Genet. . 9 . 11 . 1681–90 . 2000 . 10861295 . 10.1093/hmg/9.11.1681 . free .
• Cao X, Kambe F, Miyazaki T, etal . Novel human ZAKI-4 isoforms: hormonal and tissue-specific regulation and function as calcineurin inhibitors . Biochem. J. . 367 . Pt 2 . 459–66 . 2002 . 12102656 . 10.1042/BJ20011797 . 1222895 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Qin L, Zhao D, Liu X, etal . Down syndrome candidate region 1 isoform 1 mediates angiogenesis through the calcineurin-NFAT pathway . Mol. Cancer Res. . 4 . 11 . 811–20 . 2007 . 17114339 . 10.1158/1541-7786.MCR-06-0126 . free .
• Gollogly LK, Ryeom SW, Yoon SS . Down syndrome candidate region 1-like 1 (DSCR1-L1) mimics the inhibitory effects of DSCR1 on calcineurin signaling in endothelial cells and inhibits angiogenesis . J. Surg. Res. . 142 . 1 . 129–36 . 2007 . 17610901 . 10.1016/j.jss.2006.10.011 . 1995402 .

Notes and References

1. Miyazaki T, Kanou Y, Murata Y, Ohmori S, Niwa T, Maeda K, Yamamura H, Seo H . Molecular cloning of a novel thyroid hormone-responsive gene, ZAKI-4, in human skin fibroblasts . J Biol Chem . 271 . 24 . 14567–71 . Aug 1996 . 8662924 . 10.1074/jbc.271.24.14567 . free .
2. Web site: Entrez Gene: DSCR1L1 Down syndrome critical region gene 1-like 1.