RC3H1 explained

Ring finger and CCCH-type domains 1, also known as Roquin-1, is a protein that in humans is encoded by the RC3H1 gene.^[1]

Function

This gene encodes a protein containing RING-type and C3H1-type zinc finger motifs. The encoded protein recognizes and binds to a constitutive decay element (CDE) in the 3' UTR of mRNAs, leading to mRNA deadenylation and degradation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2014].

Further reading

• Bertossi A, Aichinger M, Sansonetti P, Lech M, Neff F, Pal M, Wunderlich FT, Anders HJ, Klein L, Schmidt-Supprian M . Loss of Roquin induces early death and immune deregulation but not autoimmunity . The Journal of Experimental Medicine . 208 . 9 . 1749–56 . August 2011 . 21844204 . 3171092 . 10.1084/jem.20110578 .
• Leppek K, Schott J, Reitter S, Poetz F, Hammond MC, Stoecklin G . Roquin promotes constitutive mRNA decay via a conserved class of stem-loop recognition motifs . Cell . 153 . 4 . 869–81 . May 2013 . 23663784 . 10.1016/j.cell.2013.04.016 . free .
• Heissmeyer V, Vogel KU . Molecular control of Tfh-cell differentiation by Roquin family proteins . Immunological Reviews . 253 . 1 . 273–89 . May 2013 . 23550652 . 10.1111/imr.12056 . 22131153 . free .
• Chang PP, Lee SK, Hu X, Davey G, Duan G, Cho JH, Karupiah G, Sprent J, Heath WR, Bertram EM, Vinuesa CG . Breakdown in repression of IFN-γ mRNA leads to accumulation of self-reactive effector CD8+ T cells . Journal of Immunology . 189 . 2 . 701–10 . July 2012 . 22685317 . 10.4049/jimmunol.1102432 . free .
• Athanasopoulos V, Barker A, Yu D, Tan AH, Srivastava M, Contreras N, Wang J, Lam KP, Brown SH, Goodnow CC, Dixon NE, Leedman PJ, Saint R, Vinuesa CG . The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs . The FEBS Journal . 277 . 9 . 2109–27 . May 2010 . 20412057 . 10.1111/j.1742-4658.2010.07628.x . free .
• Yu D, Tan AH, Hu X, Athanasopoulos V, Simpson N, Silva DG, Hutloff A, Giles KM, Leedman PJ, Lam KP, Goodnow CC, Vinuesa CG . Roquin represses autoimmunity by limiting inducible T-cell co-stimulator messenger RNA . Nature . 450 . 7167 . 299–303 . November 2007 . 18172933 . 10.1038/nature06253 . 2007Natur.450..299D . 4398665 .
• Pratama A, Ramiscal RR, Silva DG, Das SK, Athanasopoulos V, Fitch J, Botelho NK, Chang PP, Hu X, Hogan JJ, Maña P, Bernal D, Korner H, Yu D, Goodnow CC, Cook MC, Vinuesa CG . Roquin-2 shares functions with its paralog Roquin-1 in the repression of mRNAs controlling T follicular helper cells and systemic inflammation . Immunity . 38 . 4 . 669–80 . April 2013 . 23583642 . 10.1016/j.immuni.2013.01.011 . free .
• Vinuesa CG, Cook MC, Angelucci C, Athanasopoulos V, Rui L, Hill KM, Yu D, Domaschenz H, Whittle B, Lambe T, Roberts IS, Copley RR, Bell JI, Cornall RJ, Goodnow CC . A RING-type ubiquitin ligase family member required to repress follicular helper T cells and autoimmunity . Nature . 435 . 7041 . 452–8 . May 2005 . 15917799 . 10.1038/nature03555 . 2005Natur.435..452V . 4413889 .
• Linterman MA, Rigby RJ, Wong R, Silva D, Withers D, Anderson G, Verma NK, Brink R, Hutloff A, Goodnow CC, Vinuesa CG . Roquin differentiates the specialized functions of duplicated T cell costimulatory receptor genes CD28 and ICOS . Immunity . 30 . 2 . 228–41 . February 2009 . 19217324 . 10.1016/j.immuni.2008.12.015 . free .

Notes and References

1. Web site: Entrez Gene: Ring finger and CCCH-type domains 1 .