RBP1 explained

Retinol binding protein 1, cellular, also known as RBP1, is a protein that in humans is encoded by the RBP1 gene.^{[1] [2]}

Function

RBP1 is the carrier protein involved in the transport of retinol (vitamin A alcohol) from the liver storage site to peripheral tissue. Vitamin A is a fat-soluble vitamin necessary for growth, reproduction, differentiation of epithelial tissues, and vision. The gene harbors four exons encoding 24, 59, 33, and 16 amino acid residues, respectively. The second intervening sequence alone occupies 19 kb of the 21 kb of the gene.^[3]

Clinical significance

Cellular retinol-binding protein-1 (CRBP-1) contributes to the maintenance of the differentiative state of endometrial cells through the regulation of bioavailability of retinol. On the converse, loss of CRBP-1 is associated with development of endometrial cancer.^[4]

Further reading

• Herr FM, Ong DE . Differential interaction of lecithin-retinol acyltransferase with cellular retinol binding proteins. . Biochemistry . 31 . 29 . 6748–55 . 1992 . 1322170 . 10.1021/bi00144a014 .
• Siegenthaler G, Tomatis I, Chatellard-Gruaz D, etal . Expression of CRABP-I and -II in human epidermal cells. Alteration of relative protein amounts is linked to the state of differentiation. . 287 . Biochem. J. . (Pt 2) . 2. 383–9 . 1992 . 1332671 . 10.1042/bj2870383. 1133176 .
• Aström A, Tavakkol A, Pettersson U, etal . Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro. . J. Biol. Chem. . 266 . 26 . 17662–6 . 1991 . 10.1016/S0021-9258(19)47422-X . 1654334 . free .
• Wei LN, Mertz JR, Goodman DS, Nguyen-Huu MC . Cellular retinoic acid- and cellular retinol-binding proteins: complementary deoxyribonucleic acid cloning, chromosomal assignment, and tissue specific expression. . Mol. Endocrinol. . 1 . 8 . 526–34 . 1990 . 2856408 . 10.1210/mend-1-8-526 . free .
• Colantuoni V, Cortese R, Nilsson M, etal . Cloning and sequencing of a full length cDNA corresponding to human cellular retinol-binding protein. . Biochem. Biophys. Res. Commun. . 130 . 1 . 431–9 . 1985 . 2992469 . 10.1016/0006-291X(85)90435-8 .
• Nilsson MH, Spurr NK, Lundvall J, etal . Human cellular retinol-binding protein gene organization and chromosomal location. . Eur. J. Biochem. . 173 . 1 . 35–44 . 1988 . 3356192 . 10.1111/j.1432-1033.1988.tb13963.x . free .
• Sherman DR, Lloyd RS, Chytil F . Rat cellular retinol-binding protein: cDNA sequence and rapid retinol-dependent accumulation of mRNA. . Proc. Natl. Acad. Sci. U.S.A. . 84 . 10 . 3209–13 . 1987 . 3472205 . 10.1073/pnas.84.10.3209 . 304838 . 1987PNAS...84.3209S . free .
• Kooistra T, Lansink M, Arts J, etal . Involvement of retinoic acid receptor alpha in the stimulation of tissue-type plasminogen-activator gene expression in human endothelial cells. . Eur. J. Biochem. . 232 . 2 . 425–32 . 1995 . 7556191 . 10.1111/j.1432-1033.1995.425zz.x . free .
• Jaconi S, Rose K, Hughes GJ, etal . Characterization of two post-translationally processed forms of human serum retinol-binding protein: altered ratios in chronic renal failure. . J. Lipid Res. . 36 . 6 . 1247–53 . 1995 . 10.1016/S0022-2275(20)41132-0 . 7666002 . free .
• Liu W, Hellman P, Li Q, etal . Biosynthesis and function of all-trans- and 9-cis-retinoic acid in parathyroid cells. . Biochem. Biophys. Res. Commun. . 229 . 3 . 922–9 . 1997 . 9005841 . 10.1006/bbrc.1996.1903 .
• Sundaram M, Sivaprasadarao A, DeSousa MM, Findlay JB . The transfer of retinol from serum retinol-binding protein to cellular retinol-binding protein is mediated by a membrane receptor. . J. Biol. Chem. . 273 . 6 . 3336–42 . 1998 . 9452451 . 10.1074/jbc.273.6.3336 . free .
• De Baere E, Speleman F, Van Roy N, etal . Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization. . Cytogenet. Cell Genet. . 82 . 3–4 . 226–7 . 1999 . 9858824 . 10.1159/000015107 . 46851294 .
• Christensen EI, Moskaug JO, Vorum H, etal . Evidence for an essential role of megalin in transepithelial transport of retinol. . J. Am. Soc. Nephrol. . 10 . 4 . 685–95 . 1999 . 10.1681/ASN.V104685 . 10203351 . free .
• Skowyra D, Zeremski M, Neznanov N, etal . Differential association of products of alternative transcripts of the candidate tumor suppressor ING1 with the mSin3/HDAC1 transcriptional corepressor complex. . J. Biol. Chem. . 276 . 12 . 8734–9 . 2001 . 11118440 . 10.1074/jbc.M007664200 . free .
• Folli C, Calderone V, Ottonello S, etal . Identification, retinoid binding, and x-ray analysis of a human retinol-binding protein. . Proc. Natl. Acad. Sci. U.S.A. . 98 . 7 . 3710–5 . 2001 . 11274389 . 10.1073/pnas.061455898 . 31117 . 2001PNAS...98.3710F . free .
• Orlandi A, Francesconi A, Clément S, etal . High levels of cellular retinol binding protein-1 expression in leiomyosarcoma: possible implications for diagnostic evaluation. . Virchows Arch. . 441 . 1 . 31–40 . 2002 . 12111198 . 10.1007/s00428-001-0576-7 . 195243470 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Cvetković D, Williams SJ, Hamilton TC . Loss of cellular retinol-binding protein 1 gene expression in microdissected human ovarian cancer. . Clin. Cancer Res. . 9 . 3 . 1013–20 . 2003 . 12631600 .
• Hosaka B, Park SI, Felipe CR, etal . Predictive value of urinary retinol binding protein for graft dysfunction after kidney transplantation. . Transplant. Proc. . 35 . 4 . 1341–3 . 2004 . 12826154 . 10.1016/S0041-1345(03)00380-4 .
• Schmitt-Gräff A, Ertelt V, Allgaier HP, etal . Cellular retinol-binding protein-1 in hepatocellular carcinoma correlates with beta-catenin, Ki-67 index, and patient survival. . Hepatology . 38 . 2 . 470–80 . 2003 . 12883492 . 10.1053/jhep.2003.50321 . 23904734 . free .

Notes and References

1. Aström A, Tavakkol A, Pettersson U, Cromie M, Elder JT, Voorhees JJ . Molecular cloning of two human cellular retinoic acid-binding proteins (CRABP). Retinoic acid-induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro . J. Biol. Chem. . 266 . 26 . 17662–6 . September 1991 . 10.1016/S0021-9258(19)47422-X . 1654334 . free .
2. De Baere E, Speleman F, Van Roy N, De Paepe A, Messiaen L . Assignment of the cellular retinol-binding protein 1 gene (RBP1) and of the coatomer beta subunit gene (COPB2) to human chromosome band 3q23 by in situ hybridization . Cytogenet. Cell Genet. . 82 . 3–4 . 226–7 . 1998 . 9858824 . 10.1159/000015107. 46851294 .
3. Web site: Entrez Gene: RBP1 retinol binding protein 1, cellular.
4. Orlandi A, Ferlosio A, Ciucci A, Francesconi A, Lifschitz-Mercer B, Gabbiani G, Spagnoli LG, Czernobilsky B . Cellular retinol binding protein-1 expression in endometrial hyperplasia and carcinoma: diagnostic and possible therapeutic implications . Mod. Pathol. . 19 . 6 . 797–803 . June 2006 . 16575402 . 10.1038/modpathol.3800586 . free .