Retinoblastoma-like protein 2 explained

Retinoblastoma-like protein 2 is a protein that in humans is encoded by the RBL2 gene.^{[1] [2]}

Interactions

Retinoblastoma-like protein 2 has been shown to interact with:

• BRCA1,^[3]
• BRF1^[4]
• C-Raf,^[5]
• Cyclin E1,^{[6] [7]}
• Cyclin-dependent kinase 2,^{[6] [8]}
• HDAC1,^{[9] [10]}
• Prohibitin,^[11] and
• RBBP8.^{[12] [13]}

See also

• Pocket protein family

References

Further reading

• Soprano KJ, Purev E, Vuocolo S, Soprano DR . Rb2/p130 and protein phosphatase 2A: key mediators of ovarian carcinoma cell growth suppression by all-trans retinoic acid . Oncogene . 25 . 38 . 5315–25 . Aug 2006 . 16936753 . 10.1038/sj.onc.1209679 . 19893445 .
• De Falco G, Giordano A . pRb2/p130: a new candidate for retinoblastoma tumor formation . Oncogene . 25 . 38 . 5333–40 . Aug 2006 . 16936755 . 10.1038/sj.onc.1209614 . 40396708 .
• Hijmans EM, Voorhoeve PM, Beijersbergen RL, van 't Veer LJ, Bernards R . E2F-5, a new E2F family member that interacts with p130 in vivo . Molecular and Cellular Biology . 15 . 6 . 3082–9 . Jun 1995 . 7760804 . 230539 . 10.1128/mcb.15.6.3082.
• Sardet C, Vidal M, Cobrinik D, Geng Y, Onufryk C, Chen A, Weinberg RA . E2F-4 and E2F-5, two members of the E2F family, are expressed in the early phases of the cell cycle . Proceedings of the National Academy of Sciences of the United States of America . 92 . 6 . 2403–7 . Mar 1995 . 7892279 . 42492 . 10.1073/pnas.92.6.2403 . 1995PNAS...92.2403S . free .
• Yeung RS, Bell DW, Testa JR, Mayol X, Baldi A, Graña X, Klinga-Levan K, Knudson AG, Giordano A . The retinoblastoma-related gene, RB2, maps to human chromosome 16q12 and rat chromosome 19 . Oncogene . 8 . 12 . 3465–8 . Dec 1993 . 8247552 .
• Li Y, Graham C, Lacy S, Duncan AM, Whyte P . The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E . Genes & Development . 7 . 12A . 2366–77 . Dec 1993 . 8253383 . 10.1101/gad.7.12a.2366 . free .
• Hannon GJ, Demetrick D, Beach D . Isolation of the Rb-related p130 through its interaction with CDK2 and cyclins . Genes & Development . 7 . 12A . 2378–91 . Dec 1993 . 8253384 . 10.1101/gad.7.12a.2378 . free .
• Lavender P, Vandel L, Bannister AJ, Kouzarides T . The HMG-box transcription factor HBP1 is targeted by the pocket proteins and E1A . Oncogene . 14 . 22 . 2721–8 . Jun 1997 . 9178770 . 10.1038/sj.onc.1201243 . free .
• Lacy S, Whyte P . Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes . Oncogene . 14 . 20 . 2395–406 . May 1997 . 9188854 . 10.1038/sj.onc.1201085 . 26359262 .
• Shao Z, Siegert JL, Ruppert S, Robbins PD . Rb interacts with TAF(II)250/TFIID through multiple domains . Oncogene . 15 . 4 . 385–92 . Jul 1997 . 9242374 . 10.1038/sj.onc.1201204 . free .
• Sterner JM, Dew-Knight S, Musahl C, Kornbluth S, Horowitz JM . Negative regulation of DNA replication by the retinoblastoma protein is mediated by its association with MCM7 . Molecular and Cellular Biology . 18 . 5 . 2748–57 . May 1998 . 9566894 . 110654 . 10.1128/mcb.18.5.2748.
• Woitach JT, Zhang M, Niu CH, Thorgeirsson SS . A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability . Nature Genetics . 19 . 4 . 371–4 . Aug 1998 . 9697699 . 10.1038/1258 . 11374970 .
• Veal E, Eisenstein M, Tseng ZH, Gill G . A cellular repressor of E1A-stimulated genes that inhibits activation by E2F . Molecular and Cellular Biology . 18 . 9 . 5032–41 . Sep 1998 . 9710587 . 109088 . 10.1128/mcb.18.9.5032.
• Fusco C, Reymond A, Zervos AS . Molecular cloning and characterization of a novel retinoblastoma-binding protein . Genomics . 51 . 3 . 351–8 . Aug 1998 . 9721205 . 10.1006/geno.1998.5368 .
• Ferreira R, Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D . The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase . Proceedings of the National Academy of Sciences of the United States of America . 95 . 18 . 10493–8 . Sep 1998 . 9724731 . 27922 . 10.1073/pnas.95.18.10493 . 1998PNAS...9510493F . free .
• Paramio JM, Laín S, Segrelles C, Lane EB, Jorcano JL . Differential expression and functionally co-operative roles for the retinoblastoma family of proteins in epidermal differentiation . Oncogene . 17 . 8 . 949–57 . Aug 1998 . 9747874 . 10.1038/sj.onc.1202031 . 21804961 . free .
• Wang S, Ghosh RN, Chellappan SP . Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation . Molecular and Cellular Biology . 18 . 12 . 7487–98 . Dec 1998 . 9819434 . 109329 . 10.1128/mcb.18.12.7487.
• Yang R, Müller C, Huynh V, Fung YK, Yee AS, Koeffler HP . Functions of cyclin A1 in the cell cycle and its interactions with transcription factor E2F-1 and the Rb family of proteins . Molecular and Cellular Biology . 19 . 3 . 2400–7 . Mar 1999 . 10022926 . 84032 . 10.1128/mcb.19.3.2400.

Notes and References

1. Mayol X, Graña X, Baldi A, Sang N, Hu Q, Giordano A . Cloning of a new member of the retinoblastoma gene family (pRb2) which binds to the E1A transforming domain . Oncogene . 8 . 9 . 2561–6 . Sep 1993 . 8361765 .
2. Baldi A, Boccia V, Claudio PP, De Luca A, Giordano A . Genomic structure of the human retinoblastoma-related Rb2/p130 gene . Proceedings of the National Academy of Sciences of the United States of America . 93 . 10 . 4629–32 . May 1996 . 8643454 . 39329 . 10.1073/pnas.93.10.4629 . 1996PNAS...93.4629B . free .
3. Fan S, Yuan R, Ma YX, Xiong J, Meng Q, Erdos M, Zhao JN, Goldberg ID, Pestell RG, Rosen EM . Disruption of BRCA1 LXCXE motif alters BRCA1 functional activity and regulation of RB family but not RB protein binding . Oncogene . 20 . 35 . 4827–41 . Aug 2001 . 11521194 . 10.1038/sj.onc.1204666 . free .
4. Sutcliffe JE, Cairns CA, McLees A, Allison SJ, Tosh K, White RJ . RNA polymerase III transcription factor IIIB is a target for repression by pocket proteins p107 and p130 . Molecular and Cellular Biology . 19 . 6 . 4255–61 . Jun 1999 . 10330166 . 104385 . 10.1128/mcb.19.6.4255.
5. Wang S, Ghosh RN, Chellappan SP . Raf-1 physically interacts with Rb and regulates its function: a link between mitogenic signaling and cell cycle regulation . Molecular and Cellular Biology . 18 . 12 . 7487–98 . Dec 1998 . 9819434 . 109329 . 10.1128/mcb.18.12.7487.
6. Shanahan F, Seghezzi W, Parry D, Mahony D, Lees E . Cyclin E associates with BAF155 and BRG1, components of the mammalian SWI-SNF complex, and alters the ability of BRG1 to induce growth arrest . Molecular and Cellular Biology . 19 . 2 . 1460–9 . Feb 1999 . 9891079 . 116074 . 10.1128/mcb.19.2.1460.
7. Li Y, Graham C, Lacy S, Duncan AM, Whyte P . The adenovirus E1A-associated 130-kD protein is encoded by a member of the retinoblastoma gene family and physically interacts with cyclins A and E . Genes & Development . 7 . 12A . 2366–77 . Dec 1993 . 8253383 . 10.1101/gad.7.12a.2366. free .
8. Lacy S, Whyte P . Identification of a p130 domain mediating interactions with cyclin A/cdk 2 and cyclin E/cdk 2 complexes . Oncogene . 14 . 20 . 2395–406 . May 1997 . 9188854 . 10.1038/sj.onc.1201085 . 26359262 .
9. Ferreira R, Magnaghi-Jaulin L, Robin P, Harel-Bellan A, Trouche D . The three members of the pocket proteins family share the ability to repress E2F activity through recruitment of a histone deacetylase . Proceedings of the National Academy of Sciences of the United States of America . 95 . 18 . 10493–8 . Sep 1998 . 9724731 . 27922 . 10.1073/pnas.95.18.10493. 1998PNAS...9510493F . free .
10. Bouzahzah B, Fu M, Iavarone A, Factor VM, Thorgeirsson SS, Pestell RG . Transforming growth factor-beta1 recruits histone deacetylase 1 to a p130 repressor complex in transgenic mice in vivo . Cancer Research . 60 . 16 . 4531–7 . Aug 2000 . 10969803 .
11. Wang S, Nath N, Adlam M, Chellappan S . Prohibitin, a potential tumor suppressor, interacts with RB and regulates E2F function . Oncogene . 18 . 23 . 3501–10 . Jun 1999 . 10376528 . 10.1038/sj.onc.1202684 . 33828482 .
12. Meloni AR, Smith EJ, Nevins JR . A mechanism for Rb/p130-mediated transcription repression involving recruitment of the CtBP corepressor . Proceedings of the National Academy of Sciences of the United States of America . 96 . 17 . 9574–9 . Aug 1999 . 10449734 . 22250 . 10.1073/pnas.96.17.9574. 1999PNAS...96.9574M . free .
13. Fusco C, Reymond A, Zervos AS . Molecular cloning and characterization of a novel retinoblastoma-binding protein . Genomics . 51 . 3 . 351–8 . Aug 1998 . 9721205 . 10.1006/geno.1998.5368 .