RBBP9 explained

Putative hydrolase RBBP9 is an enzyme that in humans is encoded by the RBBP9 gene.^{[1] [2] [3]}

Function

The protein encoded by this gene is a retinoblastoma binding protein that may play a role in the regulation of cell proliferation and differentiation. Two alternatively spliced transcript variants of this gene with identical predicted protein products have been reported, one of which is a nonsense-mediated decay candidate.

Interactions

RBBP9 has been shown to interact with Retinoblastoma protein.

Further reading

• Chen JZ, Yang QS, Wang S, Meng XF, Ying K, Xie Y, Ma YM . Cloning and expression of a novel retinoblastoma binding protein cDNA, RBBP10 . Biochemical Genetics . 40 . 7–8 . 273–82 . Aug 2002 . 12296629 . 10.1023/A:1019886918029 . 8381137 .
• Chen J, Ji C, Gu S, Zhao E, Dai J, Huang L, Qian J, Ying K, Xie Y, Mao Y . Isolation and identification of a novel cDNA that encodes human yrdC protein . Journal of Human Genetics . 48 . 4 . 164–9 . 2003 . 12730717 . 10.1007/s10038-002-0001-3 . free .
• Huda Zoghbi . Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Woitach JT, Zhang M, Niu CH, Thorgeirsson SS . A retinoblastoma-binding protein that affects cell-cycle control and confers transforming ability . Nature Genetics . 19 . 4 . 371–4 . Aug 1998 . 9697699 . 10.1038/1258 . 11374970 .
2. Woitach JT, Hong R, Keck CL, Zimonjic DB, Popescu NC, Thorgeirsson SS . Assignment of the Bog gene (RBBP9) to syntenic regions of mouse chromosome 2G1-H1 and human chromosome 20p11.2 by fluorescence in situ hybridization . Cytogenetics and Cell Genetics . 85 . 3–4 . 252–3 . Oct 1999 . 10449909 . 10.1159/000015304 . 21843409 .
3. Web site: Entrez Gene: RBBP9 retinoblastoma binding protein 9.