RBBP7 explained

Histone-binding protein RBBP7 is a protein that in humans is encoded by the RBBP7 gene.[1]

Function

This protein is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that binds directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein is found in many histone deacetylase complexes, including mSin3 co-repressor complex. It is also present in protein complexes involved in chromatin assembly. This protein can interact with BRCA1 tumor-suppressor gene and may have a role in the regulation of cell proliferation and differentiation.[2]

Interactions

RBBP7 has been shown to interact with:

Further reading

Notes and References

  1. Eva Y.-H. P. Lee . Qian YW, Lee EY . Dual retinoblastoma-binding proteins with properties related to a negative regulator of ras in yeast . J Biol Chem . 270 . 43 . 25507–25513 . Dec 1995 . 7503932 . 10.1074/jbc.270.43.25507 . free .
  2. Web site: Entrez Gene: RBBP7 retinoblastoma binding protein 7.
  3. Chen GC, Guan LS, Yu JH, Li GC, Choi Kim HR, Wang ZY . Rb-associated protein 46 (RbAp46) inhibits transcriptional transactivation mediated by BRCA1 . Biochem. Biophys. Res. Commun. . 284 . 2 . 507–14 . June 2001 . 11394910 . 10.1006/bbrc.2001.5003 .
  4. Yarden RI, Brody LC . Identification of proteins that interact with BRCA1 by Far-Western library screening . J. Cell. Biochem. . 83 . 4 . 521–31 . 11746496 . 10.1002/jcb.1257. 2001 . 29703139 .
  5. Feng Q, Cao R, Xia L, Erdjument-Bromage H, Tempst P, Zhang Y . Identification and functional characterization of the p66/p68 components of the MeCP1 complex . Mol. Cell. Biol. . 22 . 2 . 536–46 . January 2002 . 11756549 . 139742 . 10.1128/mcb.22.2.536-546.2002.
  6. Yao YL, Yang WM . The metastasis-associated proteins 1 and 2 form distinct protein complexes with histone deacetylase activity . J. Biol. Chem. . 278 . 43 . 42560–8 . October 2003 . 12920132 . 10.1074/jbc.M302955200 . free .
  7. Ng HH, Zhang Y, Hendrich B, Johnson CA, Turner BM, Erdjument-Bromage H, Tempst P, Reinberg D, Bird A . MBD2 is a transcriptional repressor belonging to the MeCP1 histone deacetylase complex . Nat. Genet. . 23 . 1 . 58–61 . September 1999 . 10471499 . 10.1038/12659 . 1842/684 . 6147725 . free .
  8. Zhang Y, Ng HH, Erdjument-Bromage H, Tempst P, Bird A, Reinberg D . Analysis of the NuRD subunits reveals a histone deacetylase core complex and a connection with DNA methylation . Genes Dev. . 13 . 15 . 1924–35 . August 1999 . 10444591 . 316920 . 10.1101/gad.13.15.1924.
  9. Zhang Y, Iratni R, Erdjument-Bromage H, Tempst P, Reinberg D . Histone deacetylases and SAP18, a novel polypeptide, are components of a human Sin3 complex . Cell . 89 . 3 . 357–64 . May 1997 . 9150135 . 10.1016/s0092-8674(00)80216-0. free .
  10. Yarden RI, Brody LC . BRCA1 interacts with components of the histone deacetylase complex . Proc. Natl. Acad. Sci. U.S.A. . 96 . 9 . 4983–8 . April 1999 . 10220405 . 21803 . 10.1073/pnas.96.9.4983. 1999PNAS...96.4983Y . free .
  11. Zhang Y, Sun ZW, Iratni R, Erdjument-Bromage H, Tempst P, Hampsey M, Reinberg D . SAP30, a novel protein conserved between human and yeast, is a component of a histone deacetylase complex . Mol. Cell . 1 . 7 . 1021–31 . June 1998 . 9651585 . 10.1016/s1097-2765(00)80102-1. free .
  12. Kuzmichev A, Zhang Y, Erdjument-Bromage H, Tempst P, Reinberg D . Role of the Sin3-histone deacetylase complex in growth regulation by the candidate tumor suppressor p33(ING1) . Mol. Cell. Biol. . 22 . 3 . 835–48 . February 2002 . 11784859 . 133546 . 10.1128/mcb.22.3.835-848.2002.