RBBP6 explained

Retinoblastoma-binding protein 6 is a protein that in humans is encoded by the RBBP6 gene.^{[1] [2] [3]}

Function

The retinoblastoma tumor suppressor (pRB) protein binds with many other proteins. In various human cancers, pRB suppresses cellular proliferation and is inactivated. Cell cycle-dependent phosphorylation regulates the activity of pRB. This gene encodes a protein which binds to underphosphorylated but not phosphorylated pRB. Multiple alternatively spliced transcript variants that encode different isoforms have been found for this gene.

Interactions

RBBP6 has been shown to interact with Y box binding protein 1.^[4]

Further reading

• Simons A, Melamed-Bessudo C, Wolkowicz R, Sperling J, Sperling R, Eisenbach L, Rotter V . PACT: cloning and characterization of a cellular p53 binding protein that interacts with Rb . Oncogene . 14 . 2 . 145–55 . Jan 1997 . 9010216 . 10.1038/sj.onc.1200825 . free .
• Gao S, Witte MM, Scott RE . P2P-R protein localizes to the nucleolus of interphase cells and the periphery of chromosomes in mitotic cells which show maximum P2P-R immunoreactivity . Journal of Cellular Physiology . 191 . 2 . 145–54 . May 2002 . 12064457 . 10.1002/jcp.10084 . 25240477 .
• Colland F, Jacq X, Trouplin V, Mougin C, Groizeleau C, Hamburger A, Meil A, Wojcik J, Legrain P, Gauthier JM . Functional proteomics mapping of a human signaling pathway . Genome Research . 14 . 7 . 1324–32 . Jul 2004 . 15231748 . 442148 . 10.1101/gr.2334104 .
• Beausoleil SA, Jedrychowski M, Schwartz D, Elias JE, Villén J, Li J, Cohn MA, Cantley LC, Gygi SP . Large-scale characterization of HeLa cell nuclear phosphoproteins . Proceedings of the National Academy of Sciences of the United States of America . 101 . 33 . 12130–5 . Aug 2004 . 15302935 . 514446 . 10.1073/pnas.0404720101 . 2004PNAS..10112130B . free .
• Yoshitake Y, Nakatsura T, Monji M, Senju S, Matsuyoshi H, Tsukamoto H, Hosaka S, Komori H, Fukuma D, Ikuta Y, Katagiri T, Furukawa Y, Ito H, Shinohara M, Nakamura Y, Nishimura Y . Proliferation potential-related protein, an ideal esophageal cancer antigen for immunotherapy, identified using complementary DNA microarray analysis . Clinical Cancer Research . 10 . 19 . 6437–48 . Oct 2004 . 15475430 . 10.1158/1078-0432.CCR-04-0841 . free .
• Scott RE, White-Grindley E, Ruley HE, Chesler EJ, Williams RW . P2P-R expression is genetically coregulated with components of the translation machinery and with PUM2, a translational repressor that associates with the P2P-R mRNA . Journal of Cellular Physiology . 204 . 1 . 99–105 . Jul 2005 . 15617101 . 10.1002/jcp.20263 . 24888360 .
• Beausoleil SA, Villén J, Gerber SA, Rush J, Gygi SP . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nature Biotechnology . 24 . 10 . 1285–92 . Oct 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . Nov 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Sakai Y, Saijo M, Coelho K, Kishino T, Niikawa N, Taya Y . cDNA sequence and chromosomal localization of a novel human protein, RBQ-1 (RBBP6), that binds to the retinoblastoma gene product . Genomics . 30 . 1 . 98–101 . Nov 1995 . 8595913 . 10.1006/geno.1995.0017 .
2. Pugh DJ, Ab E, Faro A, Lutya PT, Hoffmann E, Rees DJ . DWNN, a novel ubiquitin-like domain, implicates RBBP6 in mRNA processing and ubiquitin-like pathways . BMC Structural Biology . 6 . 1 . Feb 2006 . 16396680 . 1360078 . 10.1186/1472-6807-6-1 . free .
3. Web site: Entrez Gene: RBBP6 retinoblastoma binding protein 6.
4. Chibi M, Meyer M, Skepu A, G Rees DJ, Moolman-Smook JC, Pugh DJ . RBBP6 interacts with multifunctional protein YB-1 through its RING finger domain, leading to ubiquitination and proteosomal degradation of YB-1 . Journal of Molecular Biology . 384 . 4 . 908–16 . Dec 2008 . 18851979 . 10.1016/j.jmb.2008.09.060 .