RBBP5 explained

Retinoblastoma-binding protein 5 is a protein that in humans is encoded by the RBBP5 gene.^{[1] [2]}

Function

The protein encoded by this gene is a ubiquitously expressed nuclear protein and belongs to a highly conserved subfamily of WD-repeat proteins. It is found among several proteins that bind directly to retinoblastoma protein, which regulates cell proliferation. The encoded protein interacts preferentially with the underphosphorylated retinoblastoma protein via the E1A-binding pocket B.

Interactions

RBBP5 has been shown to interact with:

• ASCL2,
• MLL,^[3]
• MLL3, and
• NCOA6.^[4]

Further reading

• Hillier LD, Lennon G, Becker M, Bonaldo MF, Chiapelli B, Chissoe S, Dietrich N, DuBuque T, Favello A, Gish W, Hawkins M, Hultman M, Kucaba T, Lacy M, Le M, Le N, Mardis E, Moore B, Morris M, Parsons J, Prange C, Rifkin L, Rohlfing T, Schellenberg K, Bento Soares M, Tan F, Thierry-Meg J, Trevaskis E, Underwood K, Wohldman P, Waterston R, Wilson R, Marra M . Generation and analysis of 280,000 human expressed sequence tags . Genome Research . 6 . 9 . 807–28 . Sep 1996 . 8889549 . 10.1101/gr.6.9.807 . free .
• Suzuki Y, Tsunoda T, Sese J, Taira H, Mizushima-Sugano J, Hata H, Ota T, Isogai T, Tanaka T, Nakamura Y, Suyama A, Sakaki Y, Morishita S, Okubo K, Sugano S . Identification and characterization of the potential promoter regions of 1031 kinds of human genes . Genome Research . 11 . 5 . 677–84 . May 2001 . 11337467 . 311086 . 10.1101/gr.gr-1640r .
• Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW . Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins . Molecular and Cellular Biology . 23 . 1 . 140–9 . Jan 2003 . 12482968 . 140670 . 10.1128/MCB.23.1.140-149.2003 .
• Hughes CM, Rozenblatt-Rosen O, Milne TA, Copeland TD, Levine SS, Lee JC, Hayes DN, Shanmugam KS, Bhattacharjee A, Biondi CA, Kay GF, Hayward NK, Hess JL, Meyerson M . Menin associates with a trithorax family histone methyltransferase complex and with the hoxc8 locus . Molecular Cell . 13 . 4 . 587–97 . Feb 2004 . 14992727 . 10.1016/S1097-2765(04)00081-4 . free .
• Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML . Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression . Molecular and Cellular Biology . 24 . 13 . 5639–49 . Jul 2004 . 15199122 . 480881 . 10.1128/MCB.24.13.5639-5649.2004 .
• Dou Y, Milne TA, Tackett AJ, Smith ER, Fukuda A, Wysocka J, Allis CD, Chait BT, Hess JL, Roeder RG . Physical association and coordinate function of the H3 K4 methyltransferase MLL1 and the H4 K16 acetyltransferase MOF . Cell . 121 . 6 . 873–85 . Jun 2005 . 15960975 . 10.1016/j.cell.2005.04.031 . 14717470 . free .
• Scacheri PC, Davis S, Odom DT, Crawford GE, Perkins S, Halawi MJ, Agarwal SK, Marx SJ, Spiegel AM, Meltzer PS, Collins FS . Genome-wide analysis of menin binding provides insights into MEN1 tumorigenesis . PLOS Genetics . 2 . 4 . e51 . Apr 2006 . 16604156 . 1428788 . 10.1371/journal.pgen.0020051 . free .
• Higa LA, Wu M, Ye T, Kobayashi R, Sun H, Zhang H . CUL4-DDB1 ubiquitin ligase interacts with multiple WD40-repeat proteins and regulates histone methylation . Nature Cell Biology . 8 . 11 . 1277–83 . Nov 2006 . 17041588 . 10.1038/ncb1490 . 22180568 .
• Olsen JV, Blagoev B, Gnad F, Macek B, Kumar C, Mortensen P, Mann M . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . Nov 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Saijo M, Sakai Y, Kishino T, Niikawa N, Matsuura Y, Morino K, Tamai K, Taya Y . Molecular cloning of a human protein that binds to the retinoblastoma protein and chromosomal mapping . Genomics . 27 . 3 . 511–9 . Jun 1995 . 7558034 . 10.1006/geno.1995.1084 .
2. Web site: Entrez Gene: RBBP5 retinoblastoma binding protein 5.
3. Yokoyama A, Wang Z, Wysocka J, Sanyal M, Aufiero DJ, Kitabayashi I, Herr W, Cleary ML . Leukemia proto-oncoprotein MLL forms a SET1-like histone methyltransferase complex with menin to regulate Hox gene expression . Molecular and Cellular Biology . 24 . 13 . 5639–49 . Jul 2004 . 15199122 . 480881 . 10.1128/MCB.24.13.5639-5649.2004 .
4. Goo YH, Sohn YC, Kim DH, Kim SW, Kang MJ, Jung DJ, Kwak E, Barlev NA, Berger SL, Chow VT, Roeder RG, Azorsa DO, Meltzer PS, Suh PG, Song EJ, Lee KJ, Lee YC, Lee JW . Activating signal cointegrator 2 belongs to a novel steady-state complex that contains a subset of trithorax group proteins . Molecular and Cellular Biology . 23 . 1 . 140–9 . Jan 2003 . 12482968 . 140670 . 10.1128/mcb.23.1.140-149.2003.