RASAL2 explained

Ras GTPase-activating protein nGAP is an enzyme that in humans is encoded by the RASAL2 gene.^{[1] [2]}

This gene encodes a protein that contains the GAP-related domain (GRD), a characteristic domain of GTPase-activating proteins (GAPs). GAPs function as activators of Ras superfamily of small GTPases. The protein encoded by this gene is able to complement the defective RasGAP function in a yeast system. Two alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.^[3]

Further reading

• Maekawa M, Nakamura S, Hattori S . Purification of a novel ras GTPase-activating protein from rat brain. . J. Biol. Chem. . 268 . 30 . 22948–52 . 1993 . 10.1016/S0021-9258(18)41618-3 . 8226805 . free .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery. . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Seki N, Ohira M, Nagase T, etal . Characterization of cDNA clones in size-fractionated cDNA libraries from human brain. . DNA Res. . 4 . 5 . 345–9 . 1998 . 9455484 . 10.1093/dnares/4.5.345 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Bouwmeester T, Bauch A, Ruffner H, etal . A physical and functional map of the human TNF-alpha/NF-kappa B signal transduction pathway. . Nat. Cell Biol. . 6 . 2 . 97–105 . 2004 . 14743216 . 10.1038/ncb1086 . 11683986 .
• Jin J, Smith FD, Stark C, etal . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. . Curr. Biol. . 14 . 16 . 1436–50 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . 2371325 . free . 2004CBio...14.1436J .
• Gregory SG, Barlow KF, McLay KE, etal . The DNA sequence and biological annotation of human chromosome 1. . Nature . 441 . 7091 . 315–21 . 2006 . 16710414 . 10.1038/nature04727 . 2006Natur.441..315G . free .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .

Notes and References

1. Noto S, Maeda T, Hattori S, Inazawa J, Imamura M, Asaka M, Hatakeyama M . A novel human RasGAP-like gene that maps within the prostate cancer susceptibility locus at chromosome 1q25 . FEBS Lett . 441 . 1 . 127–31 . Jan 1999 . 9877179 . 10.1016/S0014-5793(98)01530-0 . free .
2. Web site: Entrez Gene: RASAL2 RAS protein activator like 2.
3. Web site: Entrez Gene: RASAL2 RAS protein activator like 2.