RASA4 explained
Ras GTPase-activating protein 4 is an enzyme that in humans is encoded by the RASA4 gene.[1] [2]
This gene encodes a member of the GAP1 family of GTPase-activating proteins that suppresses the Ras/mitogen-activated protein kinase pathway in response to Ca(2+). Stimuli that increase intracellular Ca(2+) levels result in the translocation of this protein to the plasma membrane, where it activates as GTPase activity. Consequently, Ras is converted from the active GTP-bound state to the inactive GDP-bound state and no longer activates downstream pathways that regulate gene expression, cell growth, and differentiation. Multiple transcript variants encoding different isoforms have been found for this gene.[3]
Further reading
- Nagase T, Ishikawa K, Miyajima N, etal . Prediction of the coding sequences of unidentified human genes. IX. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro. . DNA Res. . 5 . 1 . 31–9 . 1998 . 9628581 . 10.1093/dnares/5.1.31 . free .
- Minagawa T, Fukuda M, Mikoshiba K . Distinct phosphoinositide binding specificity of the GAP1 family proteins: characterization of the pleckstrin homology domains of MRASAL and KIAA0538. . Biochem. Biophys. Res. Commun. . 288 . 1 . 87–90 . 2001 . 11594756 . 10.1006/bbrc.2001.5740 .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Hillier LW, Fulton RS, Fulton LA, etal . The DNA sequence of human chromosome 7. . Nature . 424 . 6945 . 157–64 . 2003 . 12853948 . 10.1038/nature01782 . 2003Natur.424..157H . free .
- Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
- Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
- Liu Q, Walker SA, Gao D, etal . CAPRI and RASAL impose different modes of information processing on Ras due to contrasting temporal filtering of Ca2+. . J. Cell Biol. . 170 . 2 . 183–90 . 2005 . 16009725 . 10.1083/jcb.200504167 . 1351313 .
- Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
Notes and References
- Lockyer PJ, Kupzig S, Cullen PJ . CAPRI regulates Ca(2+)-dependent inactivation of the Ras-MAPK pathway . Curr Biol . 11 . 12 . 981–6 . Jul 2001 . 11448776 . 10.1016/S0960-9822(01)00261-5 . 18141962 . free .
- Web site: Entrez Gene: RASA4 RAS p21 protein activator 4.
- Web site: Entrez Gene: RASA4 RAS p21 protein activator 4.
