RARRES3 explained

Retinoic acid receptor responder protein 3 is a protein that in humans is encoded by the RARRES3 gene.^{[1] [2]}

Retinoids exert biologic effects such as potent growth inhibitory and cell differentiation activities and are used in the treatment of hyperproliferative dermatological diseases. These effects are mediated by specific nuclear receptor proteins that are members of the steroid and thyroid hormone receptor superfamily of transcriptional regulators. RARRES1, RARRES2, and RARRES3 are genes whose expression is upregulated by the synthetic retinoid tazarotene. RARRES3 is thought act as a tumor suppressor or growth regulator.^[2]

Interactions

RARRES3 has been shown to interact with RNF135.^[3]

Further reading

• Nagpal S, Patel S, Jacobe H, etal . Tazarotene-induced gene 2 (TIG2), a novel retinoid-responsive gene in skin. . J. Invest. Dermatol. . 109 . 1 . 91–5 . 1997 . 9204961 . 10.1111/1523-1747.ep12276660 . free .
• DiSepio D, Ghosn C, Eckert RL, etal . Identification and characterization of a retinoid-induced class II tumor suppressor/growth regulatory gene. . Proc. Natl. Acad. Sci. U.S.A. . 95 . 25 . 14811–5 . 1999 . 9843971 . 10.1073/pnas.95.25.14811 . 24531 . 1998PNAS...9514811D . free .
• Huang SL, Shyu RY, Yeh MY, Jiang SY . Cloning and characterization of a novel retinoid-inducible gene 1(RIG1) deriving from human gastric cancer cells. . Mol. Cell. Endocrinol. . 159 . 1–2 . 15–24 . 2000 . 10687848 . 10.1016/S0303-7207(99)00207-5 . 11139637 .
• Duvic M, Helekar B, Schulz C, etal . Expression of a retinoid-inducible tumor suppressor, Tazarotene-inducible gene-3, is decreased in psoriasis and skin cancer . Clin. Cancer Res. . 6 . 8 . 3249–59 . 2000 . 10955811 .
• Deucher A, Nagpal S, Chandraratna RA, etal . The carboxy-terminal hydrophobic domain of TIG3, a class II tumor suppressor protein, is required for appropriate cellular localization and optimal biological activity . Int. J. Oncol. . 17 . 6 . 1195–203 . 2001 . 11078805 . 10.3892/ijo.17.6.1195.
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Higuchi E, Chandraratna RA, Hong WK, Lotan R . Induction of TIG3, a putative class II tumor suppressor gene, by retinoic acid in head and neck and lung carcinoma cells and its association with suppression of the transformed phenotype . Oncogene . 22 . 30 . 4627–35 . 2003 . 12879006 . 10.1038/sj.onc.1206235 . 20142546 . free .
• Sturniolo MT, Dashti SR, Deucher A, etal . A novel tumor suppressor protein promotes keratinocyte terminal differentiation via activation of type I transglutaminase . J. Biol. Chem. . 278 . 48 . 48066–73 . 2004 . 12928434 . 10.1074/jbc.M307215200 . free .
• Yoneyama M, Kikuchi M, Natsukawa T, etal . The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses . Nat. Immunol. . 5 . 7 . 730–7 . 2004 . 15208624 . 10.1038/ni1087 . 34876422 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Jiang SY, Chou JM, Leu FJ, etal . Decreased expression of type II tumor suppressor gene RARRES3 in tissues of hepatocellular carcinoma and cholangiocarcinoma . World J. Gastroenterol. . 11 . 7 . 948–53 . 2005 . 15742394 . 10.3748/wjg.v11.i7.948. 4250783 . free .
• Sturniolo MT, Chandraratna RA, Eckert RL . A novel transglutaminase activator forms a complex with type 1 transglutaminase . Oncogene . 24 . 18 . 2963–72 . 2005 . 15846304 . 10.1038/sj.onc.1208392 . free .
• Jiang SY, Wu MS, Chen LM, etal . Identification and characterization of the retinoic acid response elements in the human RIG1 gene promoter . Biochem. Biophys. Res. Commun. . 331 . 2 . 630–9 . 2005 . 15850806 . 10.1016/j.bbrc.2005.03.214 .
• Lotz K, Kellner T, Heitmann M, etal . Suppression of the TIG3 tumor suppressor gene in human ovarian carcinomas is mediated via mitogen-activated kinase-dependent and -independent mechanisms . Int. J. Cancer . 116 . 6 . 894–902 . 2005 . 15856468 . 10.1002/ijc.21127 . 19064264 . free .
• Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
• Guo Z, Chen LM, Zeng H, etal . NS1 protein of influenza A virus inhibits the function of intracytoplasmic pathogen sensor, RIG-I . Am. J. Respir. Cell Mol. Biol. . 36 . 3 . 263–9 . 2007 . 17053203 . 10.1165/rcmb.2006-0283RC .
• Chen Z, Benureau Y, Rijnbrand R, etal . GB virus B disrupts RIG-I signaling by NS3/4A-mediated cleavage of the adaptor protein MAVS . J. Virol. . 81 . 2 . 964–76 . 2007 . 17093192 . 10.1128/JVI.02076-06 . 1797450 .
• Tsai FM, Shyu RY, Jiang SY . RIG1 suppresses Ras activation and induces cellular apoptosis at the Golgi apparatus . Cell. Signal. . 19 . 5 . 989–99 . 2007 . 17196792 . 10.1016/j.cellsig.2006.11.005 .

Notes and References

1. Duvic M, Nagpal S, Asano AT, Chandraratna RA . Molecular mechanisms of tazarotene action in psoriasis . J Am Acad Dermatol . 37 . 2 Pt 3 . S18–24 . Sep 1997 . 9270552 . 10.1016/s0190-9622(97)80396-9.
2. Web site: Entrez Gene: RARRES3 retinoic acid receptor responder (tazarotene induced) 3.
3. Oshiumi . Hiroyuki . Matsumoto Misako . Hatakeyama Shigetsugu . Seya Tsukasa . Jan 2009 . Riplet/RNF135, a RING finger protein, ubiquitinates RIG-I to promote interferon-beta induction during the early phase of viral infection . J. Biol. Chem. . 284 . 2 . 807–17 . United States. 0021-9258. 19017631 . 10.1074/jbc.M804259200 . free .