RARRES1 explained

Retinoic acid receptor responder protein 1 is a protein that in humans is encoded by the RARRES1 gene.^{[1] [2] [3]}

This gene was identified as a retinoid acid (RA) receptor-responsive gene. It encodes a type 1 membrane protein. The expression of this gene is upregulated by tazarotene as well as by retinoic acid receptors. The expression of this gene is found to be downregulated in prostate cancer, which is caused by the methylation of its promoter and CpG island. Alternatively spliced transcript variant encoding distinct isoforms have been observed.^[4]

Further reading

• Jing C, El-Ghany MA, Beesley C, etal . Tazarotene-induced gene 1 (TIG1) expression in prostate carcinomas and its relationship to tumorigenicity. . J. Natl. Cancer Inst. . 94 . 7 . 482–90 . 2002 . 11929948 . 10.1093/jnci/94.7.482. free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Zhang J, Liu L, Pfeifer GP . Methylation of the retinoid response gene TIG1 in prostate cancer correlates with methylation of the retinoic acid receptor beta gene. . Oncogene . 23 . 12 . 2241–9 . 2004 . 14691453 . 10.1038/sj.onc.1207328 . free .
• Youssef EM, Chen XQ, Higuchi E, etal . Hypermethylation and silencing of the putative tumor suppressor Tazarotene-induced gene 1 in human cancers. . Cancer Res. . 64 . 7 . 2411–7 . 2004 . 15059893 . 10.1158/0008-5472.CAN-03-0164 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Mizuiri H, Yoshida K, Toge T, etal . DNA methylation of genes linked to retinoid signaling in squamous cell carcinoma of the esophagus: DNA methylation of CRBP1 and TIG1 is associated with tumor stage. . Cancer Sci. . 96 . 9 . 571–7 . 2005 . 16128742 . 10.1111/j.1349-7006.2005.00082.x . 39812145 . free . 11159114 .
• Shutoh M, Oue N, Aung PP, etal . DNA methylation of genes linked with retinoid signaling in gastric carcinoma: expression of the retinoid acid receptor beta, cellular retinol-binding protein 1, and tazarotene-induced gene 1 genes is associated with DNA methylation. . Cancer . 104 . 8 . 1609–19 . 2006 . 16134180 . 10.1002/cncr.21392 . 43346140 . free .

Notes and References

1. Nagpal S, Patel S, Asano AT, Johnson AT, Duvic M, Chandraratna RA . Tazarotene-induced gene 1 (TIG1), a novel retinoic acid receptor-responsive gene in skin . J Invest Dermatol . 106 . 2 . 269–74 . May 1996 . 8601727 . 10.1111/1523-1747.ep12340668 . free .
2. Duvic M, Nagpal S, Asano AT, Chandraratna RA . Molecular mechanisms of tazarotene action in psoriasis . J Am Acad Dermatol . 37 . 2 Pt 3 . S18–24 . Sep 1997 . 9270552 . 10.1016/s0190-9622(97)80396-9.
3. Web site: Entrez Gene: RARRES1 retinoic acid receptor responder (tazarotene induced) 1.
4. Web site: Entrez Gene: RARRES1 retinoic acid receptor responder (tazarotene induced) 1.