RAPGEF5 explained

Rap guanine nucleotide exchange factor 5 is a protein that in humans is encoded by the RAPGEF5 gene.^{[1] [2] [3]}

Members of the RAS subfamily (see HRAS; MIM 190020) of GTPases function in signal transduction as GTP/GDP-regulated switches that cycle between inactive GDP- and active GTP-bound states. Guanine nucleotide exchange factors (GEFs), such as RAPGEF5, serve as RAS activators by promoting acquisition of GTP to maintain the active GTP-bound state and are the key link between cell surface receptors and RAS activation (Rebhun et al., 2000).[supplied by OMIM]

Further reading

• de Rooij J, Rehmann H, van Triest M, etal . Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs . J. Biol. Chem. . 275 . 27 . 20829–36 . 2000 . 10777494 . 10.1074/jbc.M001113200 . free .
• Rebhun JF, Castro AF, Quilliam LA . Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction . J. Biol. Chem. . 275 . 45 . 34901–8 . 2001 . 10934204 . 10.1074/jbc.M005327200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Scherer SW, Cheung J, MacDonald JR, etal . Human chromosome 7: DNA sequence and biology . Science . 300 . 5620 . 767–72 . 2003 . 12690205 . 10.1126/science.1083423 . 2882961 . 2003Sci...300..767S .
• Suzuki Y, Yamashita R, Shirota M, etal . Sequence comparison of human and mouse genes reveals a homologous block structure in the promoter regions . Genome Res. . 14 . 9 . 1711–8 . 2004 . 15342556 . 10.1101/gr.2435604 . 515316 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Dupuy AG, L'Hoste S, Cherfils J, etal . Novel Rap1 dominant-negative mutants interfere selectively with C3G and Epac . Oncogene . 24 . 28 . 4509–20 . 2005 . 15856025 . 10.1038/sj.onc.1208647 . free .

Notes and References

1. Nagase T, Seki N, Ishikawa K, Ohira M, Kawarabayasi Y, Ohara O, Tanaka A, Kotani H, Miyajima N, Nomura N . Prediction of the coding sequences of unidentified human genes. VI. The coding sequences of 80 new genes (KIAA0201-KIAA0280) deduced by analysis of cDNA clones from cell line KG-1 and brain . DNA Res . 3 . 5 . 321–9, 341–54 . May 1997 . 9039502 . 10.1093/dnares/3.5.321 . free .
2. Ichiba T, Hoshi Y, Eto Y, Tajima N, Kuraishi Y . Characterization of GFR, a novel guanine nucleotide exchange factor for Rap1 . FEBS Lett . 457 . 1 . 85–9 . Oct 1999 . 10486569 . 10.1016/S0014-5793(99)01012-1 . 20296877 .
3. Web site: Entrez Gene: RAPGEF5 Rap guanine nucleotide exchange factor (GEF) 5.