RAP2B explained

Ras-related protein Rap-2b is a protein that in humans is encoded by the RAP2B gene.^{[1] [2]} RAP2B belongs to the Ras-related protein family.

This intronless gene belongs to a family of RAS-related genes. The proteins encoded by these genes share approximately 50% amino acid identity with the classical RAS proteins and have numerous structural features in common. The most striking difference between the RAP and RAS proteins resides in their 61st amino acid: glutamine in RAS is replaced by threonine in RAP proteins. Evidence suggests that this protein may be polyisoprenylated and palmitoylated.

Further reading

• Farrell FX, Ohmstede CA, Reep BR, Lapetina EG . cDNA sequence of a new ras-related gene (rap2b) isolated from human platelets with sequence homology to rap2 . Nucleic Acids Res. . 18 . 14 . 4281 . 1990 . 2115998 . 10.1093/nar/18.14.4281 . 331220 .
• Pizon V, Chardin P, Lerosey I, etal . Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region . Oncogene . 3 . 2 . 201–4 . 1988 . 3045729 .
• Torti M, Ramaschi G, Sinigaglia F, etal . Association of the low molecular weight GTP-binding protein rap2B with the cytoskeleton during platelet aggregation . Proc. Natl. Acad. Sci. U.S.A. . 90 . 16 . 7553–7 . 1993 . 8356055 . 10.1073/pnas.90.16.7553 . 47180 . 1993PNAS...90.7553T . free .
• Mollinedo F, Perez-Sala D, Gajate C, etal . Localization of rap1 and rap2 proteins in the gelatinase-containing granules of human neutrophils . FEBS Lett. . 326 . 1–3 . 209–14 . 1993 . 8391995 . 10.1016/0014-5793(93)81792-X . 6867463 . free .
• Farrell FX, Yamamoto K, Lapetina EG . Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated . Biochem. J. . 289 (Pt 2) . Pt 2. 349–55 . 1993 . 8424780 . 10.1042/bj2890349. 1132174 .
• Nancy V, Wolthuis RM, de Tand MF, etal . Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2 . J. Biol. Chem. . 274 . 13 . 8737–45 . 1999 . 10085114 . 10.1074/jbc.274.13.8737 . free .
• Rebhun JF, Castro AF, Quilliam LA . Identification of guanine nucleotide exchange factors (GEFs) for the Rap1 GTPase. Regulation of MR-GEF by M-Ras-GTP interaction . J. Biol. Chem. . 275 . 45 . 34901–8 . 2001 . 10934204 . 10.1074/jbc.M005327200 . free .
• Nancy V, Callebaut I, El Marjou A, de Gunzburg J . The delta subunit of retinal rod cGMP phosphodiesterase regulates the membrane association of Ras and Rap GTPases . J. Biol. Chem. . 277 . 17 . 15076–84 . 2002 . 11786539 . 10.1074/jbc.M109983200 . free .
• Evellin S, Nolte J, Tysack K, etal . Stimulation of phospholipase C-epsilon by the M3 muscarinic acetylcholine receptor mediated by cyclic AMP and the GTPase Rap2B . J. Biol. Chem. . 277 . 19 . 16805–13 . 2002 . 11877431 . 10.1074/jbc.M112024200 . free .
• Song C, Satoh T, Edamatsu H, etal . Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon . Oncogene . 21 . 53 . 8105–13 . 2002 . 12444546 . 10.1038/sj.onc.1206003 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Greco F, Sinigaglia F, Balduini C, Torti M . Activation of the small GTPase Rap2B in agonist-stimulated human platelets . J. Thromb. Haemost. . 2 . 12 . 2223–30 . 2005 . 15613030 . 10.1111/j.1538-7836.2004.01018.x . 25336596 . free .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Liu Y, Sun W, Zhang K, etal . Identification of genes differentially expressed in human primary lung squamous cell carcinoma . Lung Cancer . 56 . 3 . 307–17 . 2007 . 17316888 . 10.1016/j.lungcan.2007.01.016 .

Notes and References

1. Ohmstede CA, Farrell FX, Reep BR, Clemetson KJ, Lapetina EG . RAP2B: a RAS-related GTP-binding protein from platelets . Proc Natl Acad Sci U S A . 87 . 17 . 6527–31 . Oct 1990 . 2118648 . 54569 . 10.1073/pnas.87.17.6527 . 1990PNAS...87.6527O . free .
2. Web site: Entrez Gene: RAP2B RAP2B, member of RAS oncogene family.