RAP2A explained

Ras-related protein Rap-2a is a protein that in humans is encoded by the RAP2A gene.^[1] RAP2A is a member of the Ras-related protein family.

Interactions

RAP2A has been shown to interact with RUNDC3A,^[2] RASSF5^[3] and RALGDS.^[4]

Further reading

• Lerosey I, Chardin P, de Gunzburg J, Tavitian A . The product of the rap2 gene, member of the ras superfamily. Biochemical characterization and site-directed mutagenesis . The Journal of Biological Chemistry . 266 . 7 . 4315–21 . Mar 1991 . 10.1016/S0021-9258(20)64324-1 . 1900290 . free .
• Pizon V, Chardin P, Lerosey I, Olofsson B, Tavitian A . Human cDNAs rap1 and rap2 homologous to the Drosophila gene Dras3 encode proteins closely related to ras in the 'effector' region . Oncogene . 3 . 2 . 201–4 . Aug 1988 . 3045729 .
• Farrell FX, Yamamoto K, Lapetina EG . Prenyl group identification of rap2 proteins: a ras superfamily member other than ras that is farnesylated . The Biochemical Journal . 289 (Pt 2) . Pt 2 . 349–55 . Jan 1993 . 8424780 . 1132174 . 10.1042/bj2890349.
• Cherfils J, Ménétrey J, Le Bras G, Janoueix-Lerosey I, de Gunzburg J, Garel JR, Auzat I . Crystal structures of the small G protein Rap2A in complex with its substrate GTP, with GDP and with GTPgammaS . The EMBO Journal . 16 . 18 . 5582–91 . Sep 1997 . 9312017 . 1170190 . 10.1093/emboj/16.18.5582 .
• Janoueix-Lerosey I, Pasheva E, de Tand MF, Tavitian A, de Gunzburg J . Identification of a specific effector of the small GTP-binding protein Rap2 . European Journal of Biochemistry . 252 . 2 . 290–8 . Mar 1998 . 9523700 . 10.1046/j.1432-1327.1998.2520290.x . free .
• Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J . Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2 . The Journal of Biological Chemistry . 274 . 13 . 8737–45 . Mar 1999 . 10085114 . 10.1074/jbc.274.13.8737 . free .
• Linnemann T, Geyer M, Jaitner BK, Block C, Kalbitzer HR, Wittinghofer A, Herrmann C . Thermodynamic and kinetic characterization of the interaction between the Ras binding domain of AF6 and members of the Ras subfamily . The Journal of Biological Chemistry . 274 . 19 . 13556–62 . May 1999 . 10224125 . 10.1074/jbc.274.19.13556 . free .
• Ménétrey J, Cherfils J . Structure of the small G protein Rap2 in a non-catalytic complex with GTP . Proteins . 37 . 3 . 465–73 . Nov 1999 . 10591105 . 10.1002/(SICI)1097-0134(19991115)37:3<465::AID-PROT13>3.0.CO;2-O . free .
• de Rooij J, Rehmann H, van Triest M, Cool RH, Wittinghofer A, Bos JL . Mechanism of regulation of the Epac family of cAMP-dependent RapGEFs . The Journal of Biological Chemistry . 275 . 27 . 20829–36 . Jul 2000 . 10777494 . 10.1074/jbc.M001113200 . free .
• Husi H, Ward MA, Choudhary JS, Blackstock WP, Grant SG . Proteomic analysis of NMDA receptor-adhesion protein signaling complexes . Nature Neuroscience . 3 . 7 . 661–9 . Jul 2000 . 10862698 . 10.1038/76615 . 1842/742 . 14392630 . free .
• Traver S, Bidot C, Spassky N, Baltauss T, De Tand MF, Thomas JL, Zalc B, Janoueix-Lerosey I, Gunzburg JD . RGS14 is a novel Rap effector that preferentially regulates the GTPase activity of galphao . The Biochemical Journal . 350 Pt 1 . Pt 1 . 19–29 . Aug 2000 . 10926822 . 1221220 . 10.1042/0264-6021:3500019 .
• Gao X, Satoh T, Liao Y, Song C, Hu CD, Kariya Ki K, Kataoka T . Identification and characterization of RA-GEF-2, a Rap guanine nucleotide exchange factor that serves as a downstream target of M-Ras . The Journal of Biological Chemistry . 276 . 45 . 42219–25 . Nov 2001 . 11524421 . 10.1074/jbc.M105760200 . free .
• Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J . The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1 . Oncogene . 21 . 9 . 1381–90 . Feb 2002 . 11857081 . 10.1038/sj.onc.1205192 . 240243 .
• Song C, Satoh T, Edamatsu H, Wu D, Tadano M, Gao X, Kataoka T . Differential roles of Ras and Rap1 in growth factor-dependent activation of phospholipase C epsilon . Oncogene . 21 . 53 . 8105–13 . Nov 2002 . 12444546 . 10.1038/sj.onc.1206003 . 13499744 .
• Kuiperij HB, de Rooij J, Rehmann H, van Triest M, Wittinghofer A, Bos JL, Zwartkruis FJ . Characterisation of PDZ-GEFs, a family of guanine nucleotide exchange factors specific for Rap1 and Rap2 . Biochimica et Biophysica Acta (BBA) - Molecular Cell Research . 1593 . 2–3 . 141–9 . Feb 2003 . 12581858 . 10.1016/S0167-4889(02)00365-8 .
• Machida N, Umikawa M, Takei K, Sakima N, Myagmar BE, Taira K, Uezato H, Ogawa Y, Kariya K . Mitogen-activated protein kinase kinase kinase kinase 4 as a putative effector of Rap2 to activate the c-Jun N-terminal kinase . The Journal of Biological Chemistry . 279 . 16 . 15711–4 . Apr 2004 . 14966141 . 10.1074/jbc.C300542200 . free .
• Mitin NY, Ramocki MB, Zullo AJ, Der CJ, Konieczny SF, Taparowsky EJ . Identification and characterization of rain, a novel Ras-interacting protein with a unique subcellular localization . The Journal of Biological Chemistry . 279 . 21 . 22353–61 . May 2004 . 15031288 . 10.1074/jbc.M312867200 . free .

Notes and References

1. Web site: Entrez Gene: RAP2A RAP2A, member of RAS oncogene family.
2. Janoueix-Lerosey I, Pasheva E, de Tand MF, Tavitian A, de Gunzburg J . Identification of a specific effector of the small GTP-binding protein Rap2 . European Journal of Biochemistry . 252 . 2 . 290–8 . Mar 1998 . 9523700 . 10.1046/j.1432-1327.1998.2520290.x . free .
3. Ortiz-Vega S, Khokhlatchev A, Nedwidek M, Zhang XF, Dammann R, Pfeifer GP, Avruch J . The putative tumor suppressor RASSF1A homodimerizes and heterodimerizes with the Ras-GTP binding protein Nore1 . Oncogene . 21 . 9 . 1381–90 . Feb 2002 . 11857081 . 10.1038/sj.onc.1205192 . 240243 .
4. Nancy V, Wolthuis RM, de Tand MF, Janoueix-Lerosey I, Bos JL, de Gunzburg J . Identification and characterization of potential effector molecules of the Ras-related GTPase Rap2 . The Journal of Biological Chemistry . 274 . 13 . 8737–45 . Mar 1999 . 10085114 . 10.1074/jbc.274.13.8737 . free .