RAP1GDS1 explained

Rap1 GTPase-GDP dissociation stimulator 1 is an enzyme that in humans is encoded by the RAP1GDS1 gene.^{[1] [2] [3]}

Interactions

RAP1GDS1 has been shown to interact with KIFAP3,^[4] HRAS^[5] and RHOA.^[5]

Further reading

• Kikuchi A, Kaibuchi K, Hori Y, etal . Molecular cloning of the human cDNA for a stimulatory GDP/GTP exchange protein for c-Ki-ras p21 and smg p21. . Oncogene . 7 . 2 . 289–93 . 1992 . 1549351 .
• Shimizu K, Kawabe H, Minami S, etal . SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase. . J. Biol. Chem. . 271 . 43 . 27013–7 . 1996 . 8900189 . 10.1074/jbc.271.43.27013 . free .
• Vikis HG, Stewart S, Guan KL . SmgGDS displays differential binding and exchange activity towards different Ras isoforms. . Oncogene . 21 . 15 . 2425–32 . 2002 . 11948427 . 10.1038/sj.onc.1205306 . 6647800 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• de Bruyn KM, Zwartkruis FJ, de Rooij J, etal . The small GTPase Rap1 is activated by turbulence and is involved in integrin [alpha]IIb[beta]3-mediated cell adhesion in human megakaryocytes. . J. Biol. Chem. . 278 . 25 . 22412–7 . 2003 . 12690117 . 10.1074/jbc.M212036200 . free .
• Tiwari S, Felekkis K, Moon EY, etal . Among circulating hematopoietic cells, B-CLL uniquely expresses functional EPAC1, but EPAC1-mediated Rap1 activation does not account for PDE4 inhibitor-induced apoptosis. . Blood . 103 . 7 . 2661–7 . 2004 . 14615375 . 10.1182/blood-2003-06-2154 . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .

Notes and References

1. Riess O, Epplen C, Siedlaczck I, Epplen JT . Chromosomal assignment of the human smg GDP dissociation stimulator gene to human chromosome 4q21-q25 . Hum Genet . 92 . 6 . 629–30 . Jan 1994 . 8262526 . 10.1007/BF00420952 . 21189125 .
2. Tew GW, Lorimer EL, Berg TJ, Zhi H, Li R, Williams CL . SmgGDS regulates cell proliferation, migration, and NF-kappaB transcriptional activity in non-small cell lung carcinoma . J Biol Chem . 283 . 2 . 963–76 . Jan 2008 . 17951244 . 10.1074/jbc.M707526200 . free .
3. Web site: Entrez Gene: RAP1GDS1 RAP1, GTP-GDP dissociation stimulator 1.
4. 10.1074/jbc.271.43.27013 . Shimizu . K . Kawabe H . Minami S . Honda T . Takaishi K . Shirataki H . Takai Y . Oct 1996 . SMAP, an Smg GDS-associating protein having arm repeats and phosphorylated by Src tyrosine kinase . J. Biol. Chem. . 271 . 43 . 27013–7 . 0021-9258. 8900189 . free .
5. Vikis . Haris G . Stewart Scott . Guan Kun-Liang . Apr 2002 . SmgGDS displays differential binding and exchange activity towards different Ras isoforms . Oncogene . 21 . 15 . 2425–32 . 0950-9232. 11948427 . 10.1038/sj.onc.1205306 . 6647800 .