RAP1GAP2 explained

RAP1 GTPase activating protein 2 is a protein in humans that is encoded by the RAP1GAP2 gene.^[1]

This gene encodes a GTPase-activating protein that activates the small guanine-nucleotide-binding protein Rap1 in platelets. The protein interacts with synaptotagmin-like protein 1 and Rab27 and regulates secretion of dense granules from platelets at sites of endothelial damage. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009].

Further reading

• Neumüller O, Hoffmeister M, Babica J, Prelle C, Gegenbauer K, Smolenski AP . Synaptotagmin-like protein 1 interacts with the GTPase-activating protein Rap1GAP2 and regulates dense granule secretion in platelets . Blood . 114 . 7 . 1396–404 . August 2009 . 19528539 . 10.1182/blood-2008-05-155234 . 10197/5848 . 24339637 . free .
• Aouizerat BE, Vittinghoff E, Musone SL, Pawlikowska L, Kwok PY, Olgin JE, Tseng ZH . GWAS for discovery and replication of genetic loci associated with sudden cardiac arrest in patients with coronary artery disease . BMC Cardiovascular Disorders . 11 . 29 . June 2011 . 21658281 . 3141757 . 10.1186/1471-2261-11-29 . free .
• Balduini A, Pecci A, Lova P, Arezzi N, Marseglia C, Bellora F, Perotti C, Balduini C, Balduini CL, Torti M . Expression, activation, and subcellular localization of the Rap1 GTPase in cord blood-derived human megakaryocytes . Experimental Cell Research . 300 . 1 . 84–93 . October 2004 . 15383317 . 10.1016/j.yexcr.2004.07.011 .
• Kimura T, Mogi C, Sato K, Tomura H, Ohta H, Im DS, Kuwabara A, Kurose H, Murakami M, Okajima F . p2y5/LPA(6) attenuates LPA(1)-mediated VE-cadherin translocation and cell-cell dissociation through G(12/13) protein-Src-Rap1 . Cardiovascular Research . 92 . 1 . 149–58 . October 2011 . 21632882 . 10.1093/cvr/cvr154 . free .
• Schultess J, Danielewski O, Smolenski AP . Rap1GAP2 is a new GTPase-activating protein of Rap1 expressed in human platelets . Blood . 105 . 8 . 3185–92 . April 2005 . 15632203 . 10.1182/blood-2004-09-3605 . free . 10197/5867 . free .
• Hoffmeister M, Riha P, Neumüller O, Danielewski O, Schultess J, Smolenski AP . Cyclic nucleotide-dependent protein kinases inhibit binding of 14-3-3 to the GTPase-activating protein Rap1GAP2 in platelets . The Journal of Biological Chemistry . 283 . 4 . 2297–306 . January 2008 . 18039662 . 10.1074/jbc.M706825200 . 20190382 . free .

Notes and References

1. Web site: Entrez Gene: RAP1 GTPase activating protein 2 .