RAP1GAP explained

Rap1 GTPase-activating protein 1 is an enzyme that in humans is encoded by the RAP1GAP gene.^{[1] [2]}

Interactions

RAP1GAP has been shown to interact with MLLT4.^[3]

Further reading

• Hattori M, Minato N . Rap1 GTPase: functions, regulation, and malignancy . Journal of Biochemistry . 134 . 4 . 479–84 . October 2003 . 14607972 . 10.1093/jb/mvg180 .
• Rubinfeld B, Crosier WJ, Albert I, Conroy L, Clark R, McCormick F, Polakis P . Localization of the rap1GAP catalytic domain and sites of phosphorylation by mutational analysis . Molecular and Cellular Biology . 12 . 10 . 4634–42 . October 1992 . 1406653 . 360390 . 10.1128/mcb.12.10.4634 .
• Weiss J, Rubinfeld B, Polakis PG, McCormick F, Cavenee WK, Arden KC . The RAP1GA1 locus for human Rap1-GTPase activating protein 1 maps to chromosome 1p36.1-->p35 . Cytogenetics and Cell Genetics . 66 . 1 . 18–21 . 1994 . 8275700 . 10.1159/000133655 .
• Peterson SN, Trabalzini L, Brtva TR, Fischer T, Altschuler DL, Martelli P, Lapetina EG, Der CJ, White GC . Identification of a novel RalGDS-related protein as a candidate effector for Ras and Rap1 . The Journal of Biological Chemistry . 271 . 47 . 29903–8 . November 1996 . 8939933 . 10.1074/jbc.271.47.29903 . free .
• Kurachi H, Wada Y, Tsukamoto N, Maeda M, Kubota H, Hattori M, Iwai K, Minato N . Human SPA-1 gene product selectively expressed in lymphoid tissues is a specific GTPase-activating protein for Rap1 and Rap2. Segregate expression profiles from a rap1GAP gene product . The Journal of Biological Chemistry . 272 . 44 . 28081–8 . October 1997 . 9346962 . 10.1074/jbc.272.44.28081 . free .
• Seki N, Ohira M, Nagase T, Ishikawa K, Miyajima N, Nakajima D, Nomura N, Ohara O . Characterization of cDNA clones in size-fractionated cDNA libraries from human brain . DNA Research . 4 . 5 . 345–9 . October 1997 . 9455484 . 10.1093/dnares/4.5.345 . free .
• Mochizuki N, Ohba Y, Kiyokawa E, Kurata T, Murakami T, Ozaki T, Kitabatake A, Nagashima K, Matsuda M . Activation of the ERK/MAPK pathway by an isoform of rap1GAP associated with G alpha(i) . Nature . 400 . 6747 . 891–4 . August 1999 . 10476970 . 10.1038/23738 . 1999Natur.400..891M . 204995543 .
• Meng J, Glick JL, Polakis P, Casey PJ . Functional interaction between Galpha(z) and Rap1GAP suggests a novel form of cellular cross-talk . The Journal of Biological Chemistry . 274 . 51 . 36663–9 . December 1999 . 10593970 . 10.1074/jbc.274.51.36663 . free .
• Berruti G . A novel rap1/B-Raf/14-3-3 theta protein complex is formed in vivo during the morphogenetic differentiation of postmeiotic male germ cells . Experimental Cell Research . 257 . 1 . 172–9 . May 2000 . 10854065 . 10.1006/excr.2000.4877 .
• Kao S, Jaiswal RK, Kolch W, Landreth GE . Identification of the mechanisms regulating the differential activation of the mapk cascade by epidermal growth factor and nerve growth factor in PC12 cells . The Journal of Biological Chemistry . 276 . 21 . 18169–77 . May 2001 . 11278445 . 10.1074/jbc.M008870200 . free .
• Klinger M, Kudlacek O, Seidel MG, Freissmuth M, Sexl V . MAP kinase stimulation by cAMP does not require RAP1 but SRC family kinases . The Journal of Biological Chemistry . 277 . 36 . 32490–7 . September 2002 . 12082090 . 10.1074/jbc.M200556200 . free .
• Liu L, Schwartz BR, Tupper J, Lin N, Winn RK, Harlan JM . The GTPase Rap1 regulates phorbol 12-myristate 13-acetate-stimulated but not ligand-induced beta 1 integrin-dependent leukocyte adhesion . The Journal of Biological Chemistry . 277 . 43 . 40893–900 . October 2002 . 12091396 . 10.1074/jbc.M206208200 . free .
• de Bruyn KM, Rangarajan S, Reedquist KA, Figdor CG, Bos JL . The small GTPase Rap1 is required for Mn(2+)- and antibody-induced LFA-1- and VLA-4-mediated cell adhesion . The Journal of Biological Chemistry . 277 . 33 . 29468–76 . August 2002 . 12171996 . 10.1074/jbc.M204990200 . free . 2066/142510 . free .
• Meng J, Casey PJ . Activation of Gz attenuates Rap1-mediated differentiation of PC12 cells . The Journal of Biological Chemistry . 277 . 45 . 43417–24 . November 2002 . 12198116 . 10.1074/jbc.M204074200 . free .
• Schmitt JM, Stork PJ . Galpha and Gbeta gamma require distinct Src-dependent pathways to activate Rap1 and Ras . The Journal of Biological Chemistry . 277 . 45 . 43024–32 . November 2002 . 12221082 . 10.1074/jbc.M204006200 . free .
• Delehanty LL, Mogass M, Gonias SL, Racke FK, Johnstone B, Goldfarb AN . Stromal inhibition of megakaryocytic differentiation is associated with blockade of sustained Rap1 activation . Blood . 101 . 5 . 1744–51 . March 2003 . 12393469 . 10.1182/blood-2002-04-1278 . free .
• Grader-Beck T, van Puijenbroek AA, Nadler LM, Boussiotis VA . cAMP inhibits both Ras and Rap1 activation in primary human T lymphocytes, but only Ras inhibition correlates with blockade of cell cycle progression . Blood . 101 . 3 . 998–1006 . February 2003 . 12393539 . 10.1182/blood-2002-06-1665 . free .
• Gendron L, Oligny JF, Payet MD, Gallo-Payet N . Cyclic AMP-independent involvement of Rap1/B-Raf in the angiotensin II AT2 receptor signaling pathway in NG108-15 cells . The Journal of Biological Chemistry . 278 . 6 . 3606–14 . February 2003 . 12464615 . 10.1074/jbc.M202446200 . free .

Notes and References

1. Rubinfeld B, Munemitsu S, Clark R, Conroy L, Watt K, Crosier WJ, McCormick F, Polakis P . Molecular cloning of a GTPase activating protein specific for the Krev-1 protein p21rap1 . Cell . 65 . 6 . 1033–42 . June 1991 . 1904317 . 10.1016/0092-8674(91)90555-D . 45725280 .
2. Web site: Entrez Gene: RAP1GAP RAP1 GTPase activating protein.
3. Su L, Hattori M, Moriyama M, Murata N, Harazaki M, Kaibuchi K, Minato N . AF-6 controls integrin-mediated cell adhesion by regulating Rap1 activation through the specific recruitment of Rap1GTP and SPA-1 . The Journal of Biological Chemistry . 278 . 17 . 15232–8 . April 2003 . 12590145 . 10.1074/jbc.M211888200 . free . 2433/148462 . free .