RAP1B explained

Ras-related protein Rap-1b, also known as GTP-binding protein smg p21B, is a protein that in humans is encoded by the RAP1B gene.^{[1] [2] [3] [4]}

Further reading

• Rehmann H, Arias-Palomo E, Hadders MA, etal . Structure of Epac2 in complex with a cyclic AMP analogue and RAP1B. . Nature . 455 . 7209 . 124–7 . 2008 . 18660803 . 10.1038/nature07187 . 2008Natur.455..124R . 4393652 .
• Gyan E, Frew M, Bowen D, etal . Mutation in RAP1 is a rare event in myelodysplastic syndromes. . Leukemia . 19 . 9 . 1678–80 . 2005 . 16118622 . 10.1038/sj.leu.2403882 . free .
• Carmona G, Göttig S, Orlandi A, etal . Role of the small GTPase Rap1 for integrin activity regulation in endothelial cells and angiogenesis. . Blood . 113 . 2 . 488–97 . 2009 . 18805968 . 10.1182/blood-2008-02-138438 . 206868671 . free .
• Shattil SJ . Integrins and Src: dynamic duo of adhesion signaling. . Trends Cell Biol. . 15 . 8 . 399–403 . 2005 . 16005629 . 10.1016/j.tcb.2005.06.005 .
• Malchinkhuu E, Sato K, Maehama T, etal . Role of Rap1B and tumor suppressor PTEN in the negative regulation of lysophosphatidic acid--induced migration by isoproterenol in glioma cells. . Mol. Biol. Cell . 20 . 24 . 5156–65 . 2009 . 19864456 . 10.1091/mbc.E09-08-0692 . 2793292.
• Daumke O, Weyand M, Chakrabarti PP, etal . The GTPase-activating protein Rap1GAP uses a catalytic asparagine. . Nature . 429 . 6988 . 197–201 . 2004 . 15141215 . 10.1038/nature02505 . 2004Natur.429..197D . 4426744 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928.
• Edreira MM, Li S, Hochbaum D, etal . Phosphorylation-induced conformational changes in Rap1b: allosteric effects on switch domains and effector loop. . J. Biol. Chem. . 284 . 40 . 27480–6 . 2009 . 19651783 . 10.1074/jbc.M109.011312 . 2785677. free .
• Scrima A, Thomas C, Deaconescu D, Wittinghofer A . The Rap-RapGAP complex: GTP hydrolysis without catalytic glutamine and arginine residues. . EMBO J. . 27 . 7 . 1145–53 . 2008 . 18309292 . 10.1038/emboj.2008.30 . 2265111.
• Mehrle A, Rosenfelder H, Schupp I, etal . The LIFEdb database in 2006. . Nucleic Acids Res. . 34 . Database issue . D415-8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501.
• Canobbio I, Trionfini P, Guidetti GF, etal . Targeting of the small GTPase Rap2b, but not Rap1b, to lipid rafts is promoted by palmitoylation at Cys176 and Cys177 and is required for efficient protein activation in human platelets. . Cell. Signal. . 20 . 9 . 1662–70 . 2008 . 18582561 . 10.1016/j.cellsig.2008.05.016 .
• Bernardi B, Guidetti GF, Campus F, etal . The small GTPase Rap1b regulates the cross talk between platelet integrin alpha2beta1 and integrin alphaIIbbeta3. . Blood . 107 . 7 . 2728–35 . 2006 . 16357324 . 10.1182/blood-2005-07-3023 . 1895386.
• Matsuse M, Mitsutake N, Rogounovitch T, etal . Mutation analysis of RAP1 gene in papillary thyroid carcinomas. . Endocr. J. . 56 . 1 . 161–4 . 2009 . 18948674 . 10.1507/endocrj.k08e-244. free .
• Wiemann S, Arlt D, Huber W, etal . From ORFeome to biology: a functional genomics pipeline. . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930.
• Li YH, Werner H, Püschel AW . Rheb and mTOR regulate neuronal polarity through Rap1B. . J. Biol. Chem. . 283 . 48 . 33784–92 . 2008 . 18842593 . 10.1074/jbc.M802431200 . 2662285. free .
• Lova P, Campus F, Lombardi R, etal . Contribution of protease-activated receptors 1 and 4 and glycoprotein Ib-IX-V in the G(i)-independent activation of platelet Rap1B by thrombin. . J. Biol. Chem. . 279 . 24 . 25299–306 . 2004 . 15078882 . 10.1074/jbc.M313199200 . free .
• Yan J, Li F, Ingram DA, Quilliam LA . Rap1a is a key regulator of fibroblast growth factor 2-induced angiogenesis and together with Rap1b controls human endothelial cell functions. . Mol. Cell. Biol. . 28 . 18 . 5803–10 . 2008 . 18625726 . 10.1128/MCB.00393-08 . 2546931.
• Campus F, Lova P, Bertoni A, etal . Thrombopoietin complements G(i)- but not G(q)-dependent pathways for integrin (IIb)(3) activation and platelet aggregation. . J. Biol. Chem. . 280 . 26 . 24386–95 . 2005 . 15863506 . 10.1074/jbc.M501174200 . free .
• Defilippi P, Di Stefano P, Cabodi S . p130Cas: a versatile scaffold in signaling networks. . Trends Cell Biol. . 16 . 5 . 257–63 . 2006 . 16581250 . 10.1016/j.tcb.2006.03.003 .

Notes and References

1. Web site: Entrez Gene: RAP1B.
2. Pizon V, Lerosey I, Chardin P, Tavitian A . Nucleotide sequence of a human cDNA encoding a ras-related protein (rap1B) . Nucleic Acids Res. . 16 . 15 . 7719 . August 1988 . 3137530 . 338441 . 10.1093/nar/16.15.7719.
3. Matsui Y, Kikuchi A, Kawata M, Kondo J, Teranishi Y, Takai Y . Molecular cloning of smg p21B and identification of smg p21 purified from bovine brain and human platelets as smg p21B . Biochem. Biophys. Res. Commun. . 166 . 2 . 1010–6 . January 1990 . 2105724 . 10.1016/0006-291X(90)90911-6.
4. Rousseau-Merck MF, Pizon V, Tavitian A, Berger R . Chromosome mapping of the human RAS-related RAP1A, RAP1B, and RAP2 genes to chromosomes 1p12----p13, 12q14, and 13q34, respectively . Cytogenet. Cell Genet. . 53 . 1 . 2–4 . 1990 . 2108841 . 10.1159/000132883.