RANBP3 explained

Ran-binding protein 3 is a protein that in humans is encoded by the RANBP3 gene.^{[1] [2]}

This gene encodes a protein with a RanBD1 domain that is found in both the nucleus and cytoplasm. This protein plays a role in nuclear export as part of a heteromeric complex. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Interactions

RANBP3 has been shown to interact with RCC1^[3] and XPO1.^{[4] [5]}

Further reading

• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Lindsay ME, Holaska JM, Welch K, etal . Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export. . J. Cell Biol. . 153 . 7 . 1391–402 . 2001 . 11425870 . 10.1083/jcb.153.7.1391 . 2150735 .
• Englmeier L, Fornerod M, Bischoff FR, etal . RanBP3 influences interactions between CRM1 and its nuclear protein export substrates. . EMBO Rep. . 2 . 10 . 926–32 . 2002 . 11571268 . 10.1093/embo-reports/kve200 . 1084078 .
• Nemergut ME, Lindsay ME, Brownawell AM, Macara IG . Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor. . J. Biol. Chem. . 277 . 20 . 17385–8 . 2002 . 11932251 . 10.1074/jbc.C100620200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Hakata Y, Yamada M, Shida H . A multifunctional domain in human CRM1 (exportin 1) mediates RanBP3 binding and multimerization of human T-cell leukemia virus type 1 Rex protein. . Mol. Cell. Biol. . 23 . 23 . 8751–61 . 2003 . 14612415 . 10.1128/MCB.23.23.8751-8761.2003 . 262658 .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Grimwood J, Gordon LA, Olsen A, etal . The DNA sequence and biology of human chromosome 19. . Nature . 428 . 6982 . 529–35 . 2004 . 15057824 . 10.1038/nature02399 . 2004Natur.428..529G . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks. . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .

Notes and References

1. Mueller L, Cordes VC, Bischoff FR, Ponstingl H . Human RanBP3, a group of nuclear RanGTP binding proteins . FEBS Lett . 427 . 3 . 330–6 . July 1998 . 9637251 . 10.1016/S0014-5793(98)00459-1 . 28405923 .
2. Web site: Entrez Gene: RANBP3 RAN binding protein 3.
3. Nemergut . Michael E . Lindsay Mark E . Brownawell Amy M . Macara Ian G . May 2002 . Ran-binding protein 3 links Crm1 to the Ran guanine nucleotide exchange factor . J. Biol. Chem. . 277 . 20 . 17385–8 . 0021-9258. 11932251 . 10.1074/jbc.C100620200 . free .
4. 10.1083/jcb.153.7.1391 . Lindsay . M E . Holaska J M . Welch K . Paschal B M . Macara I G . June 2001 . Ran-binding protein 3 is a cofactor for Crm1-mediated nuclear protein export . J. Cell Biol. . 153 . 7 . 1391–402 . 0021-9525. 11425870 . 2150735 .
5. 10.1016/S0092-8674(02)00836-X . Lindsay . Mark E . Plafker Kendra . Smith Alicia E . Clurman Bruce E . Macara Ian G . August 2002 . Npap60/Nup50 is a tri-stable switch that stimulates importin-alpha:beta-mediated nuclear protein import . Cell . 110 . 3 . 349–60 . 0092-8674. 12176322 . 15515037 . free .