RAMP1 explained

Receptor activity modifying protein 1 is a protein that in humans is encoded by the RAMP1 gene.^{[1] [2]}

The protein encoded by this gene is a member of the RAMP family of single-transmembrane-domain proteins, called receptor (calcitonin) activity modifying proteins (RAMPs). RAMPs are type I transmembrane proteins with an extracellular N terminus and a cytoplasmic C terminus. RAMPs are required to transport calcitonin-receptor-like receptor (CALCRL) to the plasma membrane. CALCRL, a receptor with seven transmembrane domains, can function as either a calcitonin gene-related peptide (CGRP) receptor or an adrenomedullin receptor, depending on which members of the RAMP family are expressed. In combination with the RAMP1 protein, CALCRL functions as the CGRP receptor. The RAMP1 protein is involved in the terminal glycosylation, maturation, and presentation of the CGRP receptor to the cell surface.^[1] The RAMP1 protein can also interact with the calcitonin receptor (CT) protein, where heteromerisation of RAMP1 with CT converts CT from a calcitonin receptor to the amylin receptor AMY₁ ^[3]

See also

• Receptor activity-modifying protein

Further reading

• Kusano S, Kukimoto-Niino M, Akasaka R, etal . Crystal structure of the human receptor activity-modifying protein 1 extracellular domain. . Protein Sci. . 17 . 11 . 1907–14 . 2008 . 18725456 . 10.1110/ps.036012.108 . 2578806 .
• Héroux M, Hogue M, Lemieux S, Bouvier M . Functional calcitonin gene-related peptide receptors are formed by the asymmetric assembly of a calcitonin receptor-like receptor homo-oligomer and a monomer of receptor activity-modifying protein-1. . J. Biol. Chem. . 282 . 43 . 31610–20 . 2007 . 17785463 . 10.1074/jbc.M701790200 . free .
• Kuwasako K, Cao YN, Nagoshi Y, etal . Characterization of the human calcitonin gene-related peptide receptor subtypes associated with receptor activity-modifying proteins. . Mol. Pharmacol. . 65 . 1 . 207–13 . 2004 . 14722252 . 10.1124/mol.65.1.207 .
• Nagoshi Y, Kuwasako K, Cao YN, etal . Tumor necrosis factor-alpha downregulates adrenomedullin receptors in human coronary artery smooth muscle cells. . Peptides . 25 . 7 . 1115–21 . 2004 . 15245870 . 10.1016/j.peptides.2004.04.010 . 54255777 .
• Kuwasako K, Kitamura K, Nagoshi Y, Eto T . Novel calcitonin-(8-32)-sensitive adrenomedullin receptors derived from co-expression of calcitonin receptor with receptor activity-modifying proteins. . Biochem. Biophys. Res. Commun. . 301 . 2 . 460–4 . 2003 . 12565884 . 10.1016/S0006-291X(02)03072-3 .
• Wang YF, Zhang J, Li J, etal . [Increased atria expression of receptor activity-modifying proteins in heart failure patients] . Zhonghua Yi Xue Yi Chuan Xue Za Zhi . 21 . 4 . 351–4 . 2004 . 15300632 .
• Eskesen K, János T, Tibor H, etal . Unaltered mRNA expression of calcitonin-like receptor and receptor activity modifying proteins in human arteries in stroke and myocardial infarction. . Ideggyogy Sz . 60 . 11–12 . 459–66 . 2007 . 18198792 .
• Foord SM, Marshall FH . RAMPs: accessory proteins for seven transmembrane domain receptors. . Trends Pharmacol. Sci. . 20 . 5 . 184–7 . 1999 . 10354609 . 10.1016/S0165-6147(99)01347-4 .
• Fitzsimmons TJ, Zhao X, Wank SA . The extracellular domain of receptor activity-modifying protein 1 is sufficient for calcitonin receptor-like receptor function. . J. Biol. Chem. . 278 . 16 . 14313–20 . 2003 . 12574158 . 10.1074/jbc.M211946200 . free .
• Kuwasako K, Kitamura K, Nagoshi Y, etal . Identification of the human receptor activity-modifying protein 1 domains responsible for agonist binding specificity. . J. Biol. Chem. . 278 . 25 . 22623–30 . 2003 . 12684503 . 10.1074/jbc.M302571200 . free .
• Bomberger JM, Parameswaran N, Hall CS, etal . Novel function for receptor activity-modifying proteins (RAMPs) in post-endocytic receptor trafficking. . J. Biol. Chem. . 280 . 10 . 9297–307 . 2005 . 15613468 . 10.1074/jbc.M413786200 . free .
• Nakazato T, Nakayama T, Naganuma T, etal . Haplotype-based case-control study of receptor (calcitonin) activity-modifying protein-1 gene in cerebral infarction. . J Hum Hypertens . 24. 5. 351–358 . 2009 . 19710695 . 10.1038/jhh.2009.68 . 24869406 .
• Cottrell GS, Padilla B, Pikios S, etal . Post-endocytic sorting of calcitonin receptor-like receptor and receptor activity-modifying protein 1. . J. Biol. Chem. . 282 . 16 . 12260–71 . 2007 . 17310067 . 10.1074/jbc.M606338200 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Kunz TH, Mueller-Steiner S, Schwerdtfeger K, etal . Interaction of receptor-activity-modifying protein1 with tubulin. . Biochim. Biophys. Acta . 1770 . 8 . 1145–50 . 2007 . 17493758 . 10.1016/j.bbagen.2007.04.002 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2002 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Udawela M, Christopoulos G, Morfis M, etal . A critical role for the short intracellular C terminus in receptor activity-modifying protein function. . Mol. Pharmacol. . 70 . 5 . 1750–60 . 2006 . 16912219 . 10.1124/mol.106.024257 . 7249716 .
• Padilla BE, Cottrell GS, Roosterman D, etal . Endothelin-converting enzyme-1 regulates endosomal sorting of calcitonin receptor-like receptor and beta-arrestins. . J. Cell Biol. . 179 . 5 . 981–97 . 2007 . 18039931 . 10.1083/jcb.200704053 . 2099187 .
• Russo AF . Ramping it up: RAMP1 and the implications for migraine. . Pharmacogenomics . 8 . 7 . 687–90 . 2007 . 18240900 . 10.2217/14622416.8.7.687 .
• Qi T, Christopoulos G, Bailey RJ, etal . Identification of N-terminal receptor activity-modifying protein residues important for calcitonin gene-related peptide, adrenomedullin, and amylin receptor function. . Mol. Pharmacol. . 74 . 4 . 1059–71 . 2008 . 18593822 . 10.1124/mol.108.047142 . 33491956 .

External links

• Web site: Calcitonin Receptors . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-12 . 2016-03-03 . https://web.archive.org/web/20160303193951/http://www.iuphar-db.org/GPCR/ChapterMenuForward?chapterID=1358 . dead .

Notes and References

1. Web site: Entrez Gene: RAMP1 .
2. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM . RAMPs regulate the transport and ligand specificity of the calcitonin-receptor-like receptor . Nature . 393 . 6683 . 333–9 . May 1998 . 9620797 . 10.1038/30666 . 1998Natur.393..333M . 4364526 .
3. • Web site: Calcitonin Receptors: Introduction . IUPHAR Database of Receptors and Ion Channels . International Union of Basic and Clinical Pharmacology . 2008-12-12 . 2016-03-03 . https://web.archive.org/web/20160303193818/http://www.iuphar-db.org/GPCR/IntroductionDisplayForward?chapterID=1358 . dead .