RALBP1 explained

RalA-binding protein 1 is a protein that in humans is encoded by the RALBP1 gene.^{[1] [2]}

Interactions

RALBP1 has been shown to interact with:

• Cyclin B1,^[3]
• HSF1,^[4]
• RALA,^{[5] [6] [7]}
• RALB,^{[1] [5] [8]} and
• REPS2.^[7]

Further reading

• Awasthi S, Sharma R, Singhal SS, Zimniak P, Awasthi YC . RLIP76, a novel transporter catalyzing ATP-dependent efflux of xenobiotics . Drug Metab. Dispos. . 30 . 12 . 1300–10 . 2003 . 12433796 . 10.1124/dmd.30.12.1300 . 623242 .
• Yamaguchi A, Urano T, Goi T, Feig LA . An Eps homology (EH) domain protein that binds to the Ral-GTPase target, RalBP1 . J. Biol. Chem. . 272 . 50 . 31230–4 . 1998 . 9395447 . 10.1074/jbc.272.50.31230 . free .
• Ikeda M, Ishida O, Hinoi T, Kishida S, Kikuchi A . Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral . J. Biol. Chem. . 273 . 2 . 814–21 . 1998 . 9422736 . 10.1074/jbc.273.2.814 . free .
• Iouzalen N, Camonis J, Moreau J . Identification and characterization in Xenopus of XsmgGDS, a RalB binding protein . Biochem. Biophys. Res. Commun. . 250 . 2 . 359–63 . 1998 . 9753634 . 10.1006/bbrc.1998.9336 .
• Suzuki J, Yamazaki Y, Li G, Kaziro Y, Koide H, Guang L . Involvement of Ras and Ral in Chemotactic Migration of Skeletal Myoblasts . Mol. Cell. Biol. . 20 . 13 . 4658–65 . 2000 . 10848592 . 85875 . 10.1128/MCB.20.13.4658-4665.2000 .
• Jullien-Flores V, Mahé Y, Mirey G, Leprince C, Meunier-Bisceuil B, Sorkin A, Camonis JH . RLIP76, an effector of the GTPase Ral, interacts with the AP2 complex: involvement of the Ral pathway in receptor endocytosis . J. Cell Sci. . 113 . 16 . 2837–44 . 2000 . 10.1242/jcs.113.16.2837 . 10910768 .
• Awasthi S, Cheng J, Singhal SS, Saini MK, Pandya U, Pikula S, Bandorowicz-Pikula J, Singh SV, Zimniak P, Awasthi YC . Novel function of human RLIP76: ATP-dependent transport of glutathione conjugates and doxorubicin . Biochemistry . 39 . 31 . 9327–34 . 2000 . 10924126 . 10.1021/bi992964c .
• Sharma R, Singhal SS, Cheng J, Yang Y, Sharma A, Zimniak P, Awasthi S, Awasthi YC . RLIP76 is the major ATP-dependent transporter of glutathione-conjugates and doxorubicin in human erythrocytes . Arch. Biochem. Biophys. . 391 . 2 . 171–9 . 2001 . 11437348 . 10.1006/abbi.2001.2395 .
• Singhal SS, Singhal J, Cheng J, Pikuła S, Sharma R, Zimniak P, Awasthi YC, Awasthi S . Purification and functional reconstitution of intact ral-binding Gtpase activating protein, RLIP76, in artificial liposomes . Acta Biochim. Pol. . 48 . 2 . 551–62 . 2002 . 11732624 . 10.18388/abp.2001_3938. free .
• Matsuzaki T, Hanai S, Kishi H, Liu Z, Bao Y, Kikuchi A, Tsuchida K, Sugino H . Regulation of endocytosis of activin type II receptors by a novel PDZ protein through Ral/Ral-binding protein 1-dependent pathway . J. Biol. Chem. . 277 . 21 . 19008–18 . 2002 . 11882656 . 10.1074/jbc.M112472200 . free .
• Singhal SS, Singhal J, Sharma R, Singh SV, Zimniak P, Awasthi YC, Awasthi S . Role of RLIP76 in lung cancer doxorubicin resistance: I. The ATPase activity of RLIP76 correlates with doxorubicin and 4-hydroxynonenal resistance in lung cancer cells . Int. J. Oncol. . 22 . 2 . 365–75 . 2003 . 12527936 . 10.3892/ijo.22.2.365 .
• Awasthi S, Singhal SS, Singhal J, Cheng J, Zimniak P, Awasthi YC . Role of RLIP76 in lung cancer doxorubicin resistance: II. Doxorubicin transport in lung cancer by RLIP76 . Int. J. Oncol. . 22 . 4 . 713–20 . 2003 . 12632060 . 10.3892/ijo.22.4.713 .
• Awasthi S, Singhal SS, Singhal J, Yang Y, Zimniak P, Awasthi YC . Role of RLIP76 in lung cancer doxorubicin resistance: III. Anti-RLIP76 antibodies trigger apoptosis in lung cancer cells and synergistically increase doxorubicin cytotoxicity . Int. J. Oncol. . 22 . 4 . 721–32 . 2003 . 12632061 . 10.3892/ijo.22.4.721 .
• Rossé C, L'Hoste S, Offner N, Picard A, Camonis J . RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis . J. Biol. Chem. . 278 . 33 . 30597–604 . 2003 . 12775724 . 10.1074/jbc.M302191200 . free .
• Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA . Ral GTPases regulate exocyst assembly through dual subunit interactions . J. Biol. Chem. . 278 . 51 . 51743–8 . 2004 . 14525976 . 10.1074/jbc.M308702200 . free .
• Gómez MI, Lee A, Reddy B, Muir A, Soong G, Pitt A, Cheung A, Prince A . Staphylococcus aureus protein A induces airway epithelial inflammatory responses by activating TNFR1 . Nat. Med. . 10 . 8 . 842–8 . 2004 . 15247912 . 10.1038/nm1079 . 1851441 . free .
• Zhang H, Zhang R, Luo Y, D'Alessio A, Pober JS, Min W . AIP1/DAB2IP, a novel member of the Ras-GAP family, transduces TRAF2-induced ASK1-JNK activation . J. Biol. Chem. . 279 . 43 . 44955–65 . 2004 . 15310755 . 10.1074/jbc.M407617200 . free .

Notes and References

1. Jullien-Flores V, Dorseuil O, Romero F, Letourneur F, Saragosti S, Berger R, Tavitian A, Gacon G, Camonis JH . Bridging Ral GTPase to Rho pathways. RLIP76, a Ral effector with CDC42/Rac GTPase-activating protein activity . J Biol Chem . 270 . 38 . 22473–7 . Oct 1995 . 7673236 . 10.1074/jbc.270.38.22473 . free .
2. Web site: Entrez Gene: RALBP1 ralA binding protein 1.
3. Rossé C, L'Hoste S, Offner N, Picard A, Camonis J . RLIP, an effector of the Ral GTPases, is a platform for Cdk1 to phosphorylate epsin during the switch off of endocytosis in mitosis . J. Biol. Chem. . 278 . 33 . 30597–604 . Aug 2003 . 12775724 . 10.1074/jbc.M302191200 . free .
4. Hu Y, Mivechi NF . HSF-1 interacts with Ral-binding protein 1 in a stress-responsive, multiprotein complex with HSP90 in vivo . J. Biol. Chem. . 278 . 19 . 17299–306 . May 2003 . 12621024 . 10.1074/jbc.M300788200 . free.
5. Moskalenko S, Tong C, Rosse C, Mirey G, Formstecher E, Daviet L, Camonis J, White MA . Ral GTPases regulate exocyst assembly through dual subunit interactions . J. Biol. Chem. . 278 . 51 . 51743–8 . Dec 2003 . 14525976 . 10.1074/jbc.M308702200 . free .
6. Cantor SB, Urano T, Feig LA . Identification and characterization of Ral-binding protein 1, a potential downstream target of Ral GTPases . Mol. Cell. Biol. . 15 . 8 . 4578–84 . Aug 1995 . 7623849 . 230698 . 10.1128/mcb.15.8.4578.
7. Ikeda M, Ishida O, Hinoi T, Kishida S, Kikuchi A . Identification and characterization of a novel protein interacting with Ral-binding protein 1, a putative effector protein of Ral . J. Biol. Chem. . 273 . 2 . 814–21 . Jan 1998 . 9422736 . 10.1074/jbc.273.2.814. free .
8. Rual JF, Venkatesan K, Hao T, Hirozane-Kishikawa T, Dricot A, Li N, Berriz GF, Gibbons FD, Dreze M, Ayivi-Guedehoussou N, Klitgord N, Simon C, Boxem M, Milstein S, Rosenberg J, Goldberg DS, Zhang LV, Wong SL, Franklin G, Li S, Albala JS, Lim J, Fraughton C, Llamosas E, Cevik S, Bex C, Lamesch P, Sikorski RS, Vandenhaute J, Zoghbi HY, Smolyar A, Bosak S, Sequerra R, Doucette-Stamm L, Cusick ME, Hill DE, Roth FP, Vidal M . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–8 . Oct 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .