RAET1G explained

Retinoic acid early transcript 1G (RAET1G) is a cell surface glycoprotein encoded by RAET1G gene located on chromosome 6.[1] RAET1G is related to MHC class I molecules, but its gene maps outside the MHC locus. RAET1G is composed of an external α1α2 domain, a transmembrane segment, and C-terminal cytoplasmic tail.[2] RAET1E functions as a stress-induced ligand for NKG2D receptors.

Notes and References

  1. A Cluster of Ten Novel MHC Class I Related Genes on Human Chromosome 6q24.2–q25.3. Genomics. 2002-01-01. 114–123. 79. 1. 10.1006/geno.2001.6673. Mirjana. Radosavljevic. Benoı̂t. Cuillerier. Michael J.. Wilson. Oliver. Clément. Sophie. Wicker. Susan. Gilfillan. Stephan. Beck. John. Trowsdale. Seiamak. Bahram. 11827464.
  2. Two Human ULBP/RAET1 Molecules with Transmembrane Regions Are Ligands for NKG2D. The Journal of Immunology. 2004-07-15. 0022-1767. 15240696. 1078–1084. 173. 2. 10.4049/jimmunol.173.2.1078. Louise. Bacon. Robert A.. Eagle. Martina. Meyer. Nicholas. Easom. Neil T.. Young. John. Trowsdale. free.

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