RAET1E explained

Retinoic acid early transcript 1E (RAET1E) is a cell surface glycoprotein encoded by RAET1E gene located on the chromosome 6.^[1] RAET1E is related to MHC class I molecules, but its gene maps outside the MHC locus. RAET1E is composed of external α1α2 domain, transmembrane segment and C-terminal cytoplasmic tail.^[2] RAET1E functions as a stress-induced ligand for NKG2D receptor.

Further reading

• Chalupny NJ, Sutherland CL, Lawrence WA, Rein-Weston A, Cosman D . ULBP4 is a novel ligand for human NKG2D . Biochemical and Biophysical Research Communications . 305 . 1 . 129–35 . May 2003 . 12732206 . 10.1016/S0006-291X(03)00714-9 .
• Clark HF, Gurney AL, Abaya E, Baker K, Baldwin D, Brush J, Chen J, Chow B, Chui C, Crowley C, Currell B, Deuel B, Dowd P, Eaton D, Foster J, Grimaldi C, Gu Q, Hass PE, Heldens S, Huang A, Kim HS, Klimowski L, Jin Y, Johnson S, Lee J, Lewis L, Liao D, Mark M, Robbie E, Sanchez C, Schoenfeld J, Seshagiri S, Simmons L, Singh J, Smith V, Stinson J, Vagts A, Vandlen R, Watanabe C, Wieand D, Woods K, Xie MH, Yansura D, Yi S, Yu G, Yuan J, Zhang M, Zhang Z, Goddard A, Wood WI, Godowski P, Gray A . The secreted protein discovery initiative (SPDI), a large-scale effort to identify novel human secreted and transmembrane proteins: a bioinformatics assessment . Genome Research . 13 . 10 . 2265–70 . Oct 2003 . 12975309 . 403697 . 10.1101/gr.1293003 .
• Conejo-Garcia JR, Benencia F, Courreges MC, Khang E, Zhang L, Mohamed-Hadley A, Vinocur JM, Buckanovich RJ, Thompson CB, Levine B, Coukos G . Letal, A tumor-associated NKG2D immunoreceptor ligand, induces activation and expansion of effector immune cells . Cancer Biology & Therapy . 2 . 4 . 446–51 . 2004 . 14508119 . 10.4161/cbt.2.4.479. free .
• Conejo-Garcia JR, Benencia F, Courreges MC, Gimotty PA, Khang E, Buckanovich RJ, Frauwirth KA, Zhang L, Katsaros D, Thompson CB, Levine B, Coukos G . Ovarian carcinoma expresses the NKG2D ligand Letal and promotes the survival and expansion of CD28- antitumor T cells . Cancer Research . 64 . 6 . 2175–82 . Mar 2004 . 15026360 . 10.1158/0008-5472.CAN-03-2194 . free .
• Bacon L, Eagle RA, Meyer M, Easom N, Young NT, Trowsdale J . Two human ULBP/RAET1 molecules with transmembrane regions are ligands for NKG2D . Journal of Immunology . 173 . 2 . 1078–84 . Jul 2004 . 15240696 . 10.4049/jimmunol.173.2.1078 . free .
• Cao W, Xi X, Hao Z, Li W, Kong Y, Cui L, Ma C, Ba D, He W . RAET1E2, a soluble isoform of the UL16-binding protein RAET1E produced by tumor cells, inhibits NKG2D-mediated NK cytotoxicity . The Journal of Biological Chemistry . 282 . 26 . 18922–8 . Jun 2007 . 17470428 . 10.1074/jbc.M702504200 . free .

Notes and References

1. Radosavljevic M, Cuillerier B, Wilson MJ, Clément O, Wicker S, Gilfillan S, Beck S, Trowsdale J, Bahram S . A cluster of ten novel MHC class I related genes on human chromosome 6q24.2-q25.3 . Genomics . 79 . 1 . 114–23 . Jan 2002 . 11827464 . 10.1006/geno.2001.6673 .
2. ULBP4 is a novel ligand for human NKG2D. Biochemical and Biophysical Research Communications. 2003-05-23. 129–135. 305. 1. 10.1016/S0006-291X(03)00714-9. N. Jan Chalupny. Claire L. Sutherland. William A. Lawrence. Annie. Rein-Weston. David. Cosman. 12732206.