RABIF explained

Guanine nucleotide exchange factor MSS4 is a protein that in humans is encoded by the RABIF gene.^{[1] [2] [3]}

Function

The Sec4/Rab-related small GTP-binding proteins are involved in the regulation of intracellular vesicular transport. Mss4 stimulates GTP-GDP exchange in Sec4 and Rab and binds to a subset of genetically related Rab proteins.

Further reading

• Yu H, Schreiber SL . Structure of guanine-nucleotide-exchange factor human Mss4 and identification of its Rab-interacting surface . Nature . 376 . 6543 . 788–91 . 1995 . 7651540 . 10.1038/376788a0 . 1995Natur.376..788Y . 4368525 .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Burton JL, Slepnev V, De Camilli PV . An evolutionarily conserved domain in a subfamily of Rabs is crucial for the interaction with the guanyl nucleotide exchange factor Mss4 . J. Biol. Chem. . 272 . 6 . 3663–8 . 1997 . 9013620 . 10.1074/jbc.272.6.3663 . free .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Wixler V, Laplantine E, Geerts D, Sonnenberg A, Petersohn D, Eckes B, Paulsson M, Aumailley M . Identification of novel interaction partners for the conserved membrane proximal region of alpha-integrin cytoplasmic domains . FEBS Lett. . 445 . 2–3 . 351–5 . 1999 . 10094488 . 10.1016/S0014-5793(99)00151-9 . free .
• Strick DJ, Francescutti DM, Zhao Y, Elferink LA . Mammalian suppressor of Sec4 modulates the inhibitory effect of Rab15 during early endocytosis . J. Biol. Chem. . 277 . 36 . 32722–9 . 2002 . 12105226 . 10.1074/jbc.M205101200 . free .
• Stelzl U, Worm U, Lalowski M, Haenig C, Brembeck FH, Goehler H, Stroedicke M, Zenkner M, Schoenherr A, Koeppen S, Timm J, Mintzlaff S, Abraham C, Bock N, Kietzmann S, Goedde A, Toksöz E, Droege A, Krobitsch S, Korn B, Birchmeier W, Lehrach H, Wanker EE . A human protein-protein interaction network: a resource for annotating the proteome . Cell . 122 . 6 . 957–68 . 2005 . 16169070 . 10.1016/j.cell.2005.08.029 . 11858/00-001M-0000-0010-8592-0 . 8235923 . free .

Notes and References

1. Müller-Pillasch F, Zimmerhackl F, Lacher U, Schultz N, Hameister H, Varga G, Friess H, Büchler M, Adler G, Gress TM . Cloning of novel transcripts of the human guanine-nucleotide-exchange factor Mss4: in situ chromosomal mapping and expression in pancreatic cancer . Genomics . 46 . 3 . 389–96 . Mar 1998 . 9441742 . 10.1006/geno.1997.5049 .
2. Yu H, Schreiber SL . Cloning, Zn2+ binding, and structural characterization of the guanine nucleotide exchange factor human Mss4 . Biochemistry . 34 . 28 . 9103–10 . Aug 1995 . 7619808 . 10.1021/bi00028a020 . 10.1.1.540.2153 .
3. Web site: Entrez Gene: RABIF RAB interacting factor.