RABGEF1 explained
Rab5 GDP/GTP exchange factor is a protein that in humans is encoded by the RABGEF1 gene.[1] [2] [3]
RABGEF1 forms a complex with rabaptin-5 (RABPT5; MIM 603616) that is required for endocytic membrane fusion, and it serves as a specific guanine nucleotide exchange factor for RAB5(RAB5A; MIM 179512) (Horiuchi et al., 1997) [supplied by OMIM].
Further reading
- Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
- Horiuchi H, Lippé R, McBride HM, etal . A novel Rab5 GDP/GTP exchange factor complexed to Rabaptin-5 links nucleotide exchange to effector recruitment and function. . Cell . 90 . 6 . 1149–59 . 1997 . 9323142 . 10.1016/S0092-8674(00)80380-3 . 13972726 . free .
- Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, etal . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library. . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
- Lippé R, Miaczynska M, Rybin V, etal . Functional synergy between Rab5 effector Rabaptin-5 and exchange factor Rabex-5 when physically associated in a complex. . Mol. Biol. Cell . 12 . 7 . 2219–28 . 2001 . 11452015 . 10.1091/mbc.12.7.2219. 55678 .
- de Renzis S, Sönnichsen B, Zerial M . Divalent Rab effectors regulate the sub-compartmental organization and sorting of early endosomes. . Nat. Cell Biol. . 4 . 2 . 124–33 . 2002 . 11788822 . 10.1038/ncb744 . 6596498 .
- Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
- Hillier LW, Fulton RS, Fulton LA, etal . The DNA sequence of human chromosome 7. . Nature . 424 . 6945 . 157–64 . 2003 . 12853948 . 10.1038/nature01782 . 2003Natur.424..157H . free .
- Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
- Jin J, Smith FD, Stark C, etal . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization. . Curr. Biol. . 14 . 16 . 1436–50 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . 2371325 . free . 2004CBio...14.1436J .
- Delprato A, Merithew E, Lambright DG . Structure, exchange determinants, and family-wide rab specificity of the tandem helical bundle and Vps9 domains of Rabex-5. . Cell . 118 . 5 . 607–17 . 2004 . 15339665 . 10.1016/j.cell.2004.08.009 . 9638315 . free .
- Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
- Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
- Kimura K, Wakamatsu A, Suzuki Y, etal . Diversification of transcriptional modulation: large-scale identification and characterization of putative alternative promoters of human genes. . Genome Res. . 16 . 1 . 55–65 . 2006 . 16344560 . 10.1101/gr.4039406 . 1356129 .
- Penengo L, Mapelli M, Murachelli AG, etal . Crystal structure of the ubiquitin binding domains of rabex-5 reveals two modes of interaction with ubiquitin. . Cell . 124 . 6 . 1183–95 . 2006 . 16499958 . 10.1016/j.cell.2006.02.020 . 2639312 . free .
- Kalesnikoff J, Rios EJ, Chen CC, etal . Roles of RabGEF1/Rabex-5 domains in regulating Fc epsilon RI surface expression and Fc epsilon RI-dependent responses in mast cells. . Blood . 109 . 12 . 5308–17 . 2007 . 17341663 . 10.1182/blood-2007-01-067363 . 1890836 .
- Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .
- Delprato A, Lambright DG . Structural basis for Rab GTPase activation by VPS9 domain exchange factors. . Nat. Struct. Mol. Biol. . 14 . 5 . 406–12 . 2007 . 17450153 . 10.1038/nsmb1232 . 2254184 .
Notes and References
- Mattera R, Arighi CN, Lodge R, Zerial M, Bonifacino JS . Divalent interaction of the GGAs with the Rabaptin-5-Rabex-5 complex . EMBO J . 22 . 1 . 78–88 . Dec 2002 . 12505986 . 140067 . 10.1093/emboj/cdg015 .
- Nimmrich I, Erdmann S, Melchers U, Finke U, Hentsch S, Moyer MP, Hoffmann I, Muller O . Mary Pat Moyer . Seven genes that are differentially transcribed in colorectal tumor cell lines . Cancer Lett . 160 . 1 . 37–43 . Dec 2000 . 11098082 . 10.1016/S0304-3835(00)00553-X .
- Web site: Entrez Gene: RABGEF1 RAB guanine nucleotide exchange factor (GEF) 1.