RABEPK explained

Rab9 effector protein with Kelch motifs also known as p40 is a protein that in humans is encoded by the RABEPK gene.^{[1] [2]}

Membrane-associated p40, in together with RAB9A, facilitates the transport of the mannose 6-phosphate receptor (MPR) from endosomes to the trans-Golgi network.^[1]

Interactions

RABEPK has been shown to interact with RAB9A^[1] and FYVE finger-containing phosphoinositide kinase.^[3]

Further reading

• Aivazian D, Serrano RL, Pfeffer S . TIP47 is a key effector for Rab9 localization. . J. Cell Biol. . 173 . 6 . 917–26 . 2006 . 16769818 . 10.1083/jcb.200510010 . 2063917 .
• Rual JF, Venkatesan K, Hao T, etal . Towards a proteome-scale map of the human protein-protein interaction network. . Nature . 437 . 7062 . 1173–8 . 2005 . 16189514 . 10.1038/nature04209 . 2005Natur.437.1173R . 4427026 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Humphray SJ, Oliver K, Hunt AR, etal . DNA sequence and analysis of human chromosome 9. . Nature . 429 . 6990 . 369–74 . 2004 . 15164053 . 10.1038/nature02465 . 2734081 . 2004Natur.429..369H .
• Gstaiger M, Luke B, Hess D, etal . Control of nutrient-sensitive transcription programs by the unconventional prefoldin URI. . Science . 302 . 5648 . 1208–12 . 2003 . 14615539 . 10.1126/science.1088401 . 2003Sci...302.1208G . 26836888 .
• Ikonomov OC, Sbrissa D, Mlak K, etal . Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40. . J. Biol. Chem. . 278 . 51 . 50863–71 . 2004 . 14530284 . 10.1074/jbc.M307260200 . free .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .

Notes and References

1. Diaz E, Schimmoller F, Pfeffer SR . A novel Rab9 effector required for endosome-to-TGN transport . J Cell Biol . 138 . 2 . 283–90 . Aug 1997 . 9230071 . 2138197 . 10.1083/jcb.138.2.283 .
2. Web site: Entrez Gene: RABEPK Rab9 effector protein with kelch motifs.
3. Ikonomov . Ognian C . Sbrissa Diego . Mlak Krzysztof . Deeb Robert . Fligger Jason . Soans Aleric . Finley Russell L . Shisheva Assia . Dec 2003 . Active PIKfyve associates with and promotes the membrane attachment of the late endosome-to-trans-Golgi network transport factor Rab9 effector p40 . J. Biol. Chem. . 278 . 51 . 50863–71 . 0021-9258. 14530284 . 10.1074/jbc.M307260200 . free .