RAB6A explained

Ras-related protein Rab-6A is a protein that in humans is encoded by the RAB6A gene located in the eleventh chromosome.^[1] Its main function is the regulation of protein transport from the Golgi complex to the endoplasmic reticulum and the exocytosis along with the microtubules.

Interactions

RAB6A has been shown to interact with:

• BICD1,^[2]
• DCTN1^[3]
• ERC1,^[4] and
• KIF20A.^{[5] [6]}

References

Further reading

• Rousseau-Merck MF, Zahraoui A, Touchot N, Tavitian A, Berger R . Chromosome assignment of four RAS-related RAB genes. . Hum. Genet. . 86 . 4 . 350–4 . 1991 . 1999336 . 10.1007/BF00201831 . 30730416 .
• Goud B, Zahraoui A, Tavitian A, Saraste J . Small GTP-binding protein associated with Golgi cisternae. . Nature . 345 . 6275 . 553–6 . 1990 . 2112230 . 10.1038/345553a0 . 1990Natur.345..553G . 4341620 .
• Zahraoui A, Touchot N, Chardin P, Tavitian A . The human Rab genes encode a family of GTP-binding proteins related to yeast YPT1 and SEC4 products involved in secretion. . J. Biol. Chem. . 264 . 21 . 12394–401 . 1989 . 10.1016/S0021-9258(18)63872-4 . 2501306 . free .
• Maruyama K, Sugano S . Oligo-capping: a simple method to replace the cap structure of eukaryotic mRNAs with oligoribonucleotides. . Gene . 138 . 1–2 . 171–4 . 1994 . 8125298 . 10.1016/0378-1119(94)90802-8 .
• Beranger F, Cadwallader K, Porfiri E, Powers S, Evans T, de Gunzburg J, Hancock JF . Determination of structural requirements for the interaction of Rab6 with RabGDI and Rab geranylgeranyltransferase . J. Biol. Chem. . 269 . 18 . 13637–43 . 1994 . 10.1016/S0021-9258(17)36877-1 . 8175798 . free .
• Cremers FP, Armstrong SA, Seabra MC, Brown MS, Goldstein JL . REP-2, a Rab escort protein encoded by the choroideremia-like gene . J. Biol. Chem. . 269 . 3 . 2111–7 . 1994 . 10.1016/S0021-9258(17)42142-9 . 8294464 . free .
• Karniguian A, Zahraoui A, Tavitian A . Identification of small GTP-binding rab proteins in human platelets: thrombin-induced phosphorylation of rab3B, rab6, and rab8 proteins . Proc. Natl. Acad. Sci. U.S.A. . 90 . 16 . 7647–51 . 1993 . 8356066 . 47199 . 10.1073/pnas.90.16.7647 . 1993PNAS...90.7647K . free .
• Andersson B, Wentland MA, Ricafrente JY, Liu W, Gibbs RA . A "double adaptor" method for improved shotgun library construction . Anal. Biochem. . 236 . 1 . 107–13 . 1996 . 8619474 . 10.1006/abio.1996.0138 .
• Bonaldo MF, Lennon G, Soares MB . Normalization and subtraction: two approaches to facilitate gene discovery . Genome Res. . 6 . 9 . 791–806 . 1997 . 8889548 . 10.1101/gr.6.9.791 . free .
• Yu W, Andersson B, Worley KC, Muzny DM, Ding Y, Liu W, Ricafrente JY, Wentland MA, Lennon G, Gibbs RA . Large-scale concatenation cDNA sequencing . Genome Res. . 7 . 4 . 353–8 . 1997 . 9110174 . 139146 . 10.1101/gr.7.4.353 .
• Suzuki Y, Yoshitomo-Nakagawa K, Maruyama K, Suyama A, Sugano S . Construction and characterization of a full length-enriched and a 5'-end-enriched cDNA library . Gene . 200 . 1–2 . 149–56 . 1997 . 9373149 . 10.1016/S0378-1119(97)00411-3 .
• Echard A, Jollivet F, Martinez O, Lacapère JJ, Rousselet A, Janoueix-Lerosey I, Goud B . Interaction of a Golgi-associated kinesin-like protein with Rab6 . Science . 279 . 5350 . 580–5 . 1998 . 9438855 . 10.1126/science.279.5350.580 . 1998Sci...279..580E .
• Cuif MH, Possmayer F, Zander H, Bordes N, Jollivet F, Couedel-Courteille A, Janoueix-Lerosey I, Langsley G, Bornens M, Goud B . Characterization of GAPCenA, a GTPase activating protein for Rab6, part of which associates with the centrosome . EMBO J. . 18 . 7 . 1772–82 . 1999 . 10202141 . 1171263 . 10.1093/emboj/18.7.1772 .
• Barr FA . A novel Rab6-interacting domain defines a family of Golgi-targeted coiled-coil proteins . Curr. Biol. . 9 . 7 . 381–4 . 1999 . 10209123 . 10.1016/S0960-9822(99)80167-5 . free . 1999CBio....9..381B .
• Bucci C, Chiariello M, Lattero D, Maiorano M, Bruni CB . Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1) . Biochem. Biophys. Res. Commun. . 258 . 3 . 657–62 . 1999 . 10329441 . 10.1006/bbrc.1999.0651 .
• Caillol N, Pasqualini E, Lloubes R, Lombardo D . Impairment of bile salt-dependent lipase secretion in human pancreatic tumoral SOJ-6 cells . J. Cell. Biochem. . 79 . 4 . 628–47 . 2000 . 10996854 . 10.1002/1097-4644(20001215)79:4<628::AID-JCB120>3.0.CO;2-T . 11614620 .
• Shan J, Mason JM, Yuan L, Barcia M, Porti D, Calabro A, Budman D, Vinciguerra V, Xu H . Rab6c, a new member of the rab gene family, is involved in drug resistance in MCF7/AdrR cells . Gene . 257 . 1 . 67–75 . 2001 . 11054569 . 10.1016/S0378-1119(00)00395-4 . free .
• Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA . Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms . Mol. Biol. Cell . 11 . 11 . 3819–33 . 2001 . 11071909 . 15039 . 10.1091/mbc.11.11.3819 .
• Hartley JL, Temple GF, Brasch MA . DNA cloning using in vitro site-specific recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 310948 . 10.1101/gr.143000 .
• Wiemann S, Weil B, Wellenreuther R, Gassenhuber J, Glassl S, Ansorge W, Böcher M, Blöcker H, Bauersachs S, Blum H, Lauber J, Düsterhöft A, Beyer A, Köhrer K, Strack N, Mewes HW, Ottenwälder B, Obermaier B, Tampe J, Heubner D, Wambutt R, Korn B, Klein M, Poustka A . Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 311072 . 10.1101/gr.GR1547R .

Notes and References

1. Web site: Entrez Gene: RAB6A RAB6A, member RAS oncogene family.
2. Casper Hoogenraad. Matanis T, Akhmanova A, Wulf P, Del Nery E, Weide T, Stepanova T, Galjart N, Grosveld F, Goud B, De Zeeuw CI, Barnekow A, Hoogenraad CC . Bicaudal-D regulates COPI-independent Golgi-ER transport by recruiting the dynein-dynactin motor complex . Nat. Cell Biol. . 4 . 12 . 986–92 . December 2002 . 12447383 . 10.1038/ncb891 . 7953140 .
3. Short B, Preisinger C, Schaletzky J, Kopajtich R, Barr FA . The Rab6 GTPase regulates recruitment of the dynactin complex to Golgi membranes . Curr. Biol. . 12 . 20 . 1792–5 . October 2002 . 12401177 . 10.1016/s0960-9822(02)01221-6. free . 2002CBio...12.1792S .
4. Monier S, Jollivet F, Janoueix-Lerosey I, Johannes L, Goud B . Characterization of novel Rab6-interacting proteins involved in endosome-to-TGN transport . Traffic . 3 . 4 . 289–97 . April 2002 . 11929610 . 10.1034/j.1600-0854.2002.030406.x. 22993226 . free .
5. Echard A, Jollivet F, Martinez O, Lacapère JJ, Rousselet A, Janoueix-Lerosey I, Goud B . Interaction of a Golgi-associated kinesin-like protein with Rab6 . Science . 279 . 5350 . 580–5 . January 1998 . 9438855 . 10.1126/science.279.5350.580. 1998Sci...279..580E .
6. Echard A, Opdam FJ, de Leeuw HJ, Jollivet F, Savelkoul P, Hendriks W, Voorberg J, Goud B, Fransen JA . Alternative splicing of the human Rab6A gene generates two close but functionally different isoforms . Mol. Biol. Cell . 11 . 11 . 3819–33 . November 2000 . 11071909 . 15039 . 10.1091/mbc.11.11.3819.