RAB25 explained

Ras-related protein Rab-25 is a protein that in humans is encoded by the RAB25 gene.^{[1] [2]} It is thought to act as a promoter of tumor development.^[3]

Interactions

RAB25 has been shown to interact with RAB11FIP2^{[4] [5]} and RAB11FIP5.^{[4] [5]}

Further reading

• Goldenring JR, Shen KR, Vaughan HD, Modlin IM . Identification of a small GTP-binding protein, Rab25, expressed in the gastrointestinal mucosa, kidney, and lung. . J. Biol. Chem. . 268 . 25 . 18419–22 . 1993 . 10.1016/S0021-9258(17)46639-7 . 8360141 . free .
• Ray GS, Lee JR, Nwokeji K, etal . Increased immunoreactivity for Rab11, a small GTP-binding protein, in low-grade dysplastic Barrett's epithelia. . Lab. Invest. . 77 . 5 . 503–11 . 1997 . 9389793 .
• Lapierre LA, Kumar R, Hales CM, etal . Myosin vb is associated with plasma membrane recycling systems. . Mol. Biol. Cell . 12 . 6 . 1843–57 . 2001 . 11408590 . 10.1091/mbc.12.6.1843. 37346 .
• Prekeris R, Davies JM, Scheller RH . Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins. . J. Biol. Chem. . 276 . 42 . 38966–70 . 2001 . 11481332 . 10.1074/jbc.M106133200 . free .
• Hales CM, Griner R, Hobdy-Henderson KC, etal . Identification and characterization of a family of Rab11-interacting proteins. . J. Biol. Chem. . 276 . 42 . 39067–75 . 2001 . 11495908 . 10.1074/jbc.M104831200 . free .
• Suzuki H, Fukunishi Y, Kagawa I, etal . Protein-protein interaction panel using mouse full-length cDNAs. . Genome Res. . 11 . 10 . 1758–65 . 2001 . 11591653 . 10.1101/gr.180101 . 311163 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC). . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Barrios-Rodiles M, Brown KR, Ozdamar B, etal . High-throughput mapping of a dynamic signaling network in mammalian cells. . Science . 307 . 5715 . 1621–5 . 2005 . 15761153 . 10.1126/science.1105776 . 2005Sci...307.1621B . 39457788 .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry. . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .
• Fan Y, Xin XY, Chen BL, Ma X . Knockdown of RAB25 expression by RNAi inhibits growth of human epithelial ovarian cancer cells in vitro and in vivo. . Pathology . 38 . 6 . 561–7 . 2007 . 17393986 . 10.1080/00313020601024037 . 85960469 .

Notes and References

1. Pereira-Leal JB, Seabra MC . Evolution of the Rab family of small GTP-binding proteins . J Mol Biol . 313 . 4 . 889–901 . November 2001 . 11697911 . 10.1006/jmbi.2001.5072 .
2. Web site: Entrez Gene: RAB25 RAB25, member RAS oncogene family.
3. Kessler. D. Gruen. GC. Heider. D. Morgner. J. Reis. H. Schmid. KW. Jendrossek. V. The action of small GTPases Rab11 and Rab25 in vesicle trafficking during cell migration.. Cellular Physiology and Biochemistry. 2012. 29. 5–6. 647–56. 22613965. 10.1159/000295249. free.
4. Hales . C M . Griner R . Hobdy-Henderson K C . Dorn M C . Hardy D . Kumar R . Navarre J . Chan E K . Lapierre L A . Goldenring J R . October 2001 . Identification and characterization of a family of Rab11-interacting proteins . J. Biol. Chem. . 276 . 42 . 39067–75 . 0021-9258. 11495908 . 10.1074/jbc.M104831200 . free .
5. Prekeris . R . Davies J M . Scheller R H . October 2001 . Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins . J. Biol. Chem. . 276 . 42 . 38966–70 . 0021-9258. 11481332 . 10.1074/jbc.M106133200 . free .