RAB22A explained

Ras-related protein Rab-22A is a protein that in humans is encoded by the RAB22A gene.^[1]

The protein encoded by this gene is a member of the RAB family of small GTPases. The GTP-bound form of the encoded protein has been shown to interact with early-endosomal antigen 1, and may be involved in the trafficking of and interaction between endosomal compartments.

Further reading

• Bao S, Zhu J, Garvey WT . Cloning of Rab GTPases expressed in human skeletal muscle: studies in insulin-resistant subjects . Horm. Metab. Res. . 30 . 11 . 656–662 . 1999 . 9918381 . 10.1055/s-2007-978953 . 23540699 .
• Bucci C . Interaction cloning and characterization of the cDNA encoding the human prenylated rab acceptor (PRA1) . Biochem. Biophys. Res. Commun. . 258 . 3 . 657–662 . 1999 . 10329441 . 10.1006/bbrc.1999.0651 . Chiariello M . Lattero D . Maiorano . M . Bruni . C .
• Opdam FJ . Expression of Rab small GTPases in epithelial Caco-2 cells: Rab21 is an apically located GTP-binding protein in polarised intestinal epithelial cells . Eur. J. Cell Biol. . 79 . 5 . 308–316 . 2000 . 10887961 . 10.1078/S0171-9335(04)70034-5 . Kamps G . Croes H . Van Bokhoven . H . Ginsel . LA . Fransen . JA .
• Deloukas P . The DNA sequence and comparative analysis of human chromosome 20 . Nature . 414 . 6866 . 865–871 . 2002 . 11780052 . 10.1038/414865a . Matthews LH . Ashurst J . Burton . J. . Gilbert . J. G. R. . Jones . M. . Stavrides . G. . Almeida . J. P. . Babbage . A. K. . 2001Natur.414..865D . free .
• Kauppi M . The small GTPase Rab22 interacts with EEA1 and controls endosomal membrane trafficking . J. Cell Sci. . 115 . Pt 5 . 899–911 . 2002 . 11870209 . Simonsen A . Bremnes B . Vieira . A . Callaghan . J . Stenmark . H . Olkkonen . VM . 10.1242/jcs.115.5.899 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–16903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M . free .
• Seet LF, Liu N, Hanson BJ, Hong W . Endofin recruits TOM1 to endosomes . J. Biol. Chem. . 279 . 6 . 4670–4679 . 2004 . 14613930 . 10.1074/jbc.M311228200 . free .
• Ota T . Complete sequencing and characterization of 21,243 full-length human cDNAs . Nat. Genet. . 36 . 1 . 40–45 . 2004 . 14702039 . 10.1038/ng1285 . Suzuki Y . Nishikawa T . Otsuki . Tetsuji . Sugiyama . Tomoyasu . Irie . Ryotaro . Wakamatsu . Ai . Hayashi . Koji . Sato . Hiroyuki . free .
• Weigert R, Yeung AC, Li J, Donaldson JG . Rab22a regulates the recycling of membrane proteins internalized independently of clathrin . Mol. Biol. Cell . 15 . 8 . 3758–3770 . 2005 . 15181155 . 10.1091/mbc.E04-04-0342 . 491835 .
• Gerhard DS . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–2127 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Mesa R . Overexpression of Rab22a hampers the transport between endosomes and the Golgi apparatus . Exp. Cell Res. . 304 . 2 . 339–353 . 2005 . 15748882 . 10.1016/j.yexcr.2004.11.017 . Magadán J . Barbieri A . López . Cecilia . Stahl . Philip D. . Mayorga . Luis S. .
• Barrios-Rodiles M . High-throughput mapping of a dynamic signaling network in mammalian cells . Science . 307 . 5715 . 1621–1625 . 2005 . 15761153 . 10.1126/science.1105776 . Brown KR . Ozdamar B . Bose . R . Liu . Z . Donovan . RS . Shinjo . F . Liu . Y . Dembowy . J . 2005Sci...307.1621B . 39457788 .
• Rual JF . Towards a proteome-scale map of the human protein-protein interaction network . Nature . 437 . 7062 . 1173–1178 . 2005 . 16189514 . 10.1038/nature04209 . Venkatesan K . Hao T . Hirozane-Kishikawa . Tomoko . Dricot . Amélie . Li . Ning . Berriz . Gabriel F. . Gibbons . Francis D. . Dreze . Matija . 2005Natur.437.1173R . 4427026 .
• Magadán JG . Rab22a regulates the sorting of transferrin to recycling endosomes . Mol. Cell. Biol. . 26 . 7 . 2595–2614 . 2006 . 16537905 . 10.1128/MCB.26.7.2595-2614.2006 . 1430328 . Barbieri MA . Mesa R . Stahl . P. D. . Mayorga . L. S. .

Notes and References

1. Web site: Entrez Gene: RAB22A RAB22A, member RAS oncogene family.