RAB1B explained

Ras-related protein Rab-1B is a protein that in humans is encoded by the RAB1B gene.^{[1] [2]}

Interactions

RAB1B has been shown to interact with GOLGA2.^[3]

Further reading

• Plutner H, Cox AD, Pind S, etal . Rab1b regulates vesicular transport between the endoplasmic reticulum and successive Golgi compartments . J. Cell Biol. . 115 . 1 . 31–43 . 1991 . 1918138 . 10.1083/jcb.115.1.31 . 2289927 .
• Soldati T, Rancaño C, Geissler H, Pfeffer SR . Rab7 and Rab9 are recruited onto late endosomes by biochemically distinguishable processes . J. Biol. Chem. . 270 . 43 . 25541–8 . 1995 . 7592724 . 10.1074/jbc.270.43.25541 . free .
• Wilson AL, Sheridan KM, Erdman RA, Maltese WA . Prenylation of a Rab1B mutant with altered GTPase activity is impaired in cell-free systems but not in intact mammalian cells . Biochem. J. . 318 . Pt 3. 1007–14 . 1996 . 8836150 . 10.1042/bj3181007. 1217717 .
• Overmeyer JH, Wilson AL, Erdman RA, Maltese WA . The Putative "Switch 2" Domain of the Ras-related GTPase, Rab1B, Plays an Essential Role in the Interaction with Rab Escort Protein . Mol. Biol. Cell . 9 . 1 . 223–35 . 1998 . 9437002 . 10.1091/mbc.9.1.223. 25245 .
• Weide T, Koster M, Barnekow A . Inactive and active mutants of rab1b are not tightly integrated into target membranes . Int. J. Oncol. . 15 . 4 . 727–36 . 1999 . 10493955 . 10.3892/ijo.15.4.727.
• Hartley JL, Temple GF, Brasch MA . DNA Cloning Using In Vitro Site-Specific Recombination . Genome Res. . 10 . 11 . 1788–95 . 2001 . 11076863 . 10.1101/gr.143000 . 310948 .
• Wiemann S, Weil B, Wellenreuther R, etal . Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs . Genome Res. . 11 . 3 . 422–35 . 2001 . 11230166 . 10.1101/gr.GR1547R . 311072 .
• Simpson JC, Wellenreuther R, Poustka A, etal . Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing . EMBO Rep. . 1 . 3 . 287–92 . 2001 . 11256614 . 10.1093/embo-reports/kvd058 . 1083732 .
• Weide T, Bayer M, Köster M, etal . The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b . EMBO Rep. . 2 . 4 . 336–41 . 2001 . 11306556 . 10.1093/embo-reports/kve065 . 1083862 .
• Zhao H, Ettala O, Väänänen HK . Intracellular membrane trafficking pathways in bone-resorbing osteoclasts revealed by cloning and subcellular localization studies of small GTP-binding rab proteins . Biochem. Biophys. Res. Commun. . 293 . 3 . 1060–5 . 2002 . 12051767 . 10.1016/S0006-291X(02)00326-1 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Wiemann S, Arlt D, Huber W, etal . From ORFeome to Biology: A Functional Genomics Pipeline . Genome Res. . 14 . 10B . 2136–44 . 2004 . 15489336 . 10.1101/gr.2576704 . 528930 .
• Fischer J, Weide T, Barnekow A . The MICAL proteins and rab1: a possible link to the cytoskeleton? . Biochem. Biophys. Res. Commun. . 328 . 2 . 415–23 . 2005 . 15694364 . 10.1016/j.bbrc.2004.12.182 .
• Bayer M, Fischer J, Kremerskothen J, etal . Identification and characterization of Iporin as a novel interaction partner for rab1 . BMC Cell Biol. . 6 . 15 . 2006 . 1 . 15796781 . 10.1186/1471-2121-6-15 . 1079803 . free .
• Mehrle A, Rosenfelder H, Schupp I, etal . The LIFEdb database in 2006 . Nucleic Acids Res. . 34 . Database issue . D415–8 . 2006 . 16381901 . 10.1093/nar/gkj139 . 1347501 .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein–protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .
• Monetta P, Slavin I, Romero N, Alvarez C . Rab1b Interacts with GBF1 and Modulates both ARF1 Dynamics and COPI Association . Mol. Biol. Cell . 18 . 7 . 2400–10 . 2007 . 17429068 . 10.1091/mbc.E06-11-1005 . 1924811 .
• Machner MP, Isberg RR . A bifunctional bacterial protein links GDI displacement to Rab1 activation . Science . 318 . 5852 . 974–7 . 2007 . 17947549 . 10.1126/science.1149121 . 2007Sci...318..974M . 21889766 .

Notes and References

1. Chen D, Guo J, Gahl WA . RAB GTPases expressed in human melanoma cells . Biochim Biophys Acta . 1355 . 1 . 1–6 . March 1997 . 9030196 . 10.1016/S0167-4889(96)00169-3 . free .
2. Web site: Entrez Gene: RAB1B RAB1B, member RAS oncogene family.
3. Weide . T . Bayer M . Köster M . Siebrasse J P . Peters R . Barnekow A . April 2001 . The Golgi matrix protein GM130: a specific interacting partner of the small GTPase rab1b . EMBO Rep. . 2 . 4 . 336–41 . England. 1469-221X. 11306556 . 10.1093/embo-reports/kve065 . 1083862 .