RAB11FIP3 explained

Rab11 family-interacting protein 3 is a protein that in humans is encoded by the RAB11FIP3 gene.^{[1] [2] [3]}

Proteins of the large Rab GTPase family (see RAB1A; MIM 179508) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP3 is one of many proteins that interact with and regulate Rab GTPases (Hales et al., 2001).[supplied by OMIM]

Interactions

RAB11FIP3 has been shown to interact with RAB11A.^[4]

Further reading

• Shin OH, Ross AH, Mihai I, Exton JH . Identification of arfophilin, a target protein for GTP-bound class II ADP-ribosylation factors . J. Biol. Chem. . 274 . 51 . 36609–15 . 2000 . 10593962 . 10.1074/jbc.274.51.36609 . free .
• Daniels RJ, Peden JF, Lloyd C, etal . Sequence, structure and pathology of the fully annotated terminal 2 Mb of the short arm of human chromosome 16 . Hum. Mol. Genet. . 10 . 4 . 339–52 . 2001 . 11157797 . 10.1093/hmg/10.4.339 . free .
• Hales CM, Griner R, Hobdy-Henderson KC, etal . Identification and characterization of a family of Rab11-interacting proteins . J. Biol. Chem. . 276 . 42 . 39067–75 . 2001 . 11495908 . 10.1074/jbc.M104831200 . free .
• Shin OH, Couvillon AD, Exton JH . Arfophilin is a common target of both class II and class III ADP-ribosylation factors . Biochemistry . 40 . 36 . 10846–52 . 2001 . 11535061 . 10.1021/bi0107391 .
• Yang CS, Weiner H . Yeast two-hybrid screening identifies binding partners of human Tom34 that have ATPase activity and form a complex with Tom34 in the cytosol . Arch. Biochem. Biophys. . 400 . 1 . 105–10 . 2002 . 11913976 . 10.1006/abbi.2002.2778 .
• Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW . Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells . Biochem. Biophys. Res. Commun. . 299 . 5 . 770–9 . 2003 . 12470645 . 10.1016/S0006-291X(02)02720-1 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Behrends U, Schneider I, Rössler S, etal . Novel tumor antigens identified by autologous antibody screening of childhood medulloblastoma cDNA libraries . Int. J. Cancer . 106 . 2 . 244–51 . 2003 . 12800201 . 10.1002/ijc.11208 . 36836051 . free .
• Horgan CP, Walsh M, Zurawski TH, McCaffrey MW . Rab11-FIP3 localises to a Rab11-positive pericentrosomal compartment during interphase and to the cleavage furrow during cytokinesis . Biochem. Biophys. Res. Commun. . 319 . 1 . 83–94 . 2004 . 15158446 . 10.1016/j.bbrc.2004.04.157 .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Wilson GM, Fielding AB, Simon GC, etal . The FIP3-Rab11 protein complex regulates recycling endosome targeting to the cleavage furrow during late cytokinesis . Mol. Biol. Cell . 16 . 2 . 849–60 . 2005 . 15601896 . 10.1091/mbc.E04-10-0927 . 545916 .
• Martin J, Han C, Gordon LA, etal . The sequence and analysis of duplication-rich human chromosome 16 . Nature . 432 . 7020 . 988–94 . 2005 . 15616553 . 10.1038/nature03187 . 2004Natur.432..988M . free .
• Shiba T, Koga H, Shin HW, etal . Structural basis for Rab11-dependent membrane recruitment of a family of Rab11-interacting protein 3 (FIP3)/Arfophilin-1 . Proc. Natl. Acad. Sci. U.S.A. . 103 . 42 . 15416–21 . 2007 . 17030804 . 10.1073/pnas.0605357103 . 1622838 . 2006PNAS..10315416S . free .
• Horgan CP, Oleksy A, Zhdanov AV, etal . Rab11-FIP3 is critical for the structural integrity of the endosomal recycling compartment . Traffic . 8 . 4 . 414–30 . 2007 . 17394487 . 10.1111/j.1600-0854.2007.00543.x . free .
• Schonteich E, Pilli M, Simon GC, etal . Molecular characterization of Rab11-FIP3 binding to ARF GTPases . Eur. J. Cell Biol. . 86 . 8 . 417–31 . 2007 . 17628206 . 10.1016/j.ejcb.2007.05.004 .

Notes and References

1. Ishikawa K, Nagase T, Suyama M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. X. The complete sequences of 100 new cDNA clones from brain which can code for large proteins in vitro . DNA Res . 5 . 3 . 169–76 . Dec 1998 . 9734811 . 10.1093/dnares/5.3.169 . free .
2. Prekeris R, Davies JM, Scheller RH . Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins . J Biol Chem . 276 . 42 . 38966–70 . October 2001 . 11481332 . 10.1074/jbc.M106133200 . free .
3. Web site: Entrez Gene: RAB11FIP3 RAB11 family interacting protein 3 (class II).
4. Hales . C M . Griner R . Hobdy-Henderson K C . Dorn M C . Hardy D . Kumar R . Navarre J . Chan E K . Lapierre L A . Goldenring J R . October 2001 . Identification and characterization of a family of Rab11-interacting proteins . J. Biol. Chem. . 276 . 42 . 39067–75 . United States. 0021-9258. 11495908 . 10.1074/jbc.M104831200 . free .