RAB11FIP2 explained

Rab11 family-interacting protein 2 is a protein that in humans is encoded by the RAB11FIP2 gene.^{[1] [2] [3]}

Interactions

RAB11FIP2 has been shown to interact with MYO5B,^[4] RAB11A^{[5] [6]} and RAB25.^{[5] [6]}

Further reading

• Prekeris R, Davies JM, Scheller RH . Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins. . J. Biol. Chem. . 276 . 42 . 38966–70 . 2001 . 11481332 . 10.1074/jbc.M106133200 . free .
• Hales CM . Identification and characterization of a family of Rab11-interacting proteins . J. Biol. Chem. . 276 . 42 . 39067–75 . 2001 . 11495908 . 10.1074/jbc.M104831200 . Griner R . Hobdy-Henderson KC . Dorn . MC . Hardy . D . Kumar . R . Navarre . J . Chan . EK . Lapierre . LA . free .
• Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW . The novel Rab11-FIP/Rip/RCP family of proteins displays extensive homo- and hetero-interacting abilities . Biochem. Biophys. Res. Commun. . 292 . 4 . 909–15 . 2002 . 11944901 . 10.1006/bbrc.2002.6736 .
• Cullis DN, Philip B, Baleja JD, Feig LA . Rab11-FIP2, an adaptor protein connecting cellular components involved in internalization and recycling of epidermal growth factor receptors . J. Biol. Chem. . 277 . 51 . 49158–66 . 2003 . 12364336 . 10.1074/jbc.M206316200 . free .
• Hales CM, Vaerman JP, Goldenring JR . Rab11 family interacting protein 2 associates with Myosin Vb and regulates plasma membrane recycling . J. Biol. Chem. . 277 . 52 . 50415–21 . 2003 . 12393859 . 10.1074/jbc.M209270200 . free .
• Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW . Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells . Biochem. Biophys. Res. Commun. . 299 . 5 . 770–9 . 2003 . 12470645 . 10.1016/S0006-291X(02)02720-1 .
• Strausberg RL . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . Feingold EA . Grouse LH . Derge . JG . Klausner . RD . Collins . FS . Wagner . L . Shenmen . CM . Schuler . GD . 2002PNAS...9916899M. free .
• Fan GH . Rab11-Family Interacting Protein 2 and Myosin Vb Are Required for CXCR2 Recycling and Receptor-mediated Chemotaxis . Mol. Biol. Cell . 15 . 5 . 2456–69 . 2005 . 15004234 . 10.1091/mbc.E03-09-0706 . 404037 . Lapierre LA . Goldenring JR . Sai . J . Richmond . A .
• Junutula JR . Molecular characterization of Rab11 interactions with members of the family of Rab11-interacting proteins . J. Biol. Chem. . 279 . 32 . 33430–7 . 2004 . 15173169 . 10.1074/jbc.M404633200 . Schonteich E . Wilson GM . Peden . AA . Scheller . RH . Prekeris . R . free.
• Lindsay AJ, McCaffrey MW . The C2 domains of the class I Rab11 family of interacting proteins target recycling vesicles to the plasma membrane . J. Cell Sci. . 117 . Pt 19 . 4365–75 . 2005 . 15304524 . 10.1242/jcs.01280 . 7896477 .
• Jin J . Proteomic, functional, and domain-based analysis of in vivo 14-3-3 binding proteins involved in cytoskeletal regulation and cellular organization . Curr. Biol. . 14 . 16 . 1436–50 . 2004 . 15324660 . 10.1016/j.cub.2004.07.051 . Smith FD . Stark C . Wells . Clark D. . Fawcett . James P. . Kulkarni . Sarang . Metalnikov . Pavel . O'Donnell . Paul . Taylor . Paul . 2371325 . free . 2004CBio...14.1436J .
• Gerhard DS . The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 . Wagner L . Feingold EA . Shenmen . CM . Grouse . LH . Schuler . G . Klein . SL . Old . S . Rasooly . R .
• Naslavsky N . Interactions between EHD Proteins and Rab11-FIP2: A Role for EHD3 in Early Endosomal Transport . Mol. Biol. Cell . 17 . 1 . 163–77 . 2006 . 16251358 . 10.1091/mbc.E05-05-0466 . 1345656 . Rahajeng J . Sharma M . Jovic . M . Caplan . S .
• Ducharme NA . MARK2/EMK1/Par-1Bα Phosphorylation of Rab11-Family Interacting Protein 2 Is Necessary for the Timely Establishment of Polarity in Madin-Darby Canine Kidney Cells . Mol. Biol. Cell . 17 . 8 . 3625–37 . 2006 . 16775013 . 10.1091/mbc.E05-08-0736 . 1525241 . Hales CM . Lapierre LA . Ham . AJ . Oztan . A . Apodaca . G . Goldenring . JR .
• Ducharme NA . Rab11-FIP2 regulates differentiable steps in transcytosis . Am. J. Physiol., Cell Physiol. . 293 . 3 . C1059–72 . 2007 . 17626244 . 10.1152/ajpcell.00078.2007 . Williams JA . Oztan A . Apodaca . G. . Lapierre . L. A. . Goldenring . J. R. . 34368157 .

Notes and References

1. Lindsay AJ, McCaffrey MW . Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain . J Biol Chem . 277 . 30 . 27193–9 . July 2002 . 11994279 . 10.1074/jbc.M200757200 . free .
2. Nagase T, Ishikawa K, Suyama M, Kikuno R, Hirosawa M, Miyajima N, Tanaka A, Kotani H, Nomura N, Ohara O . Prediction of the coding sequences of unidentified human genes. XIII. The complete sequences of 100 new cDNA clones from brain which code for large proteins in vitro . DNA Res . 6 . 1 . 63–70 . July 1999 . 10231032 . 10.1093/dnares/6.1.63 . free .
3. Web site: Entrez Gene: RAB11FIP2 RAB11 family interacting protein 2 (class I).
4. Hales . Chadwick M . Vaerman Jean-Pierre . Goldenring James R . Dec 2002 . Rab11 family interacting protein 2 associates with Myosin Vb and regulates plasma membrane recycling . J. Biol. Chem. . 277 . 52 . 50415–21 . 0021-9258. 12393859 . 10.1074/jbc.M209270200 . free .
5. Hales . C M . Griner R . Hobdy-Henderson K C . Dorn M C . Hardy D . Kumar R . Navarre J . Chan E K . Lapierre L A . Goldenring J R . October 2001 . Identification and characterization of a family of Rab11-interacting proteins . J. Biol. Chem. . 276 . 42 . 39067–75 . 0021-9258. 11495908 . 10.1074/jbc.M104831200 . free .
6. Prekeris . R . Davies J M . Scheller R H . October 2001 . Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins . J. Biol. Chem. . 276 . 42 . 38966–70 . 0021-9258. 11481332 . 10.1074/jbc.M106133200 . free .