RAB11FIP1 explained

Rab11 family-interacting protein 1 (Rab11-FIP1) also known as Rab-coupling protein is a protein that in humans is encoded by the RAB11FIP1 gene.^{[1] [2] [3]}

Function

Proteins of the large Rab GTPase family (see for example RAB1A) have regulatory roles in the formation, targeting, and fusion of intracellular transport vesicles. RAB11FIP1 is one of many proteins that interact with and regulate Rab GTPases.^{[2] [3]} RAB11FIP1 has been identified as a novel protein involved in the regulation ofadiponectin trafficking and release from the adipocyte.^[4] RAB11FIP1 expression, which is increased with increasing BMI in humans, inhibits the release of adiponectin from the adipocyte, potentially contributing to lower circulating levels of adiponectin observed in obese populations.^[4]

Interactions

RAB11FIP1 has been shown to interact with RAB11A^[5] and RAB4A.^[1]

Further reading

• Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW . The novel Rab11-FIP/Rip/RCP family of proteins displays extensive homo- and hetero-interacting abilities. . Biochem. Biophys. Res. Commun. . 292 . 4 . 909–15 . 2002 . 11944901 . 10.1006/bbrc.2002.6736 .
• Strausberg RL, Feingold EA, Grouse LH, etal . Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences. . Proc. Natl. Acad. Sci. U.S.A. . 99 . 26 . 16899–903 . 2003 . 12477932 . 10.1073/pnas.242603899 . 139241 . 2002PNAS...9916899M . free .
• Ota T, Suzuki Y, Nishikawa T, etal . Complete sequencing and characterization of 21,243 full-length human cDNAs. . Nat. Genet. . 36 . 1 . 40–5 . 2004 . 14702039 . 10.1038/ng1285 . free .
• Thériault C, Rochdi MD, Parent JL . Role of the Rab11-associated intracellular pool of receptors formed by constitutive endocytosis of the beta isoform of the thromboxane A2 receptor (TP beta). . Biochemistry . 43 . 19 . 5600–7 . 2004 . 15134434 . 10.1021/bi036268v .
• Peden AA, Schonteich E, Chun J, etal . The RCP-Rab11 complex regulates endocytic protein sorting. . Mol. Biol. Cell . 15 . 8 . 3530–41 . 2005 . 15181150 . 10.1091/mbc.E03-12-0918 . 491816 .
• Lindsay AJ, McCaffrey MW . Characterisation of the Rab binding properties of Rab coupling protein (RCP) by site-directed mutagenesis. . FEBS Lett. . 571 . 1–3 . 86–92 . 2004 . 15280022 . 10.1016/j.febslet.2004.06.068 . 35306314 .
• Damiani MT, Pavarotti M, Leiva N, etal . Rab coupling protein associates with phagosomes and regulates recycling from the phagosomal compartment . Traffic . 5 . 10 . 785–97 . 2005 . 15355514 . 10.1111/j.1600-0854.2004.00220.x . 37310957 . free .
• Gerhard DS, Wagner L, Feingold EA, etal . The status, quality, and expansion of the NIH full-length cDNA project: the Mammalian Gene Collection (MGC) . Genome Res. . 14 . 10B . 2121–7 . 2004 . 15489334 . 10.1101/gr.2596504 . 528928 .
• Marie N, Lindsay AJ, McCaffrey MW . Rab coupling protein is selectively degraded by calpain in a Ca2+-dependent manner . Biochem. J. . 389 . Pt 1 . 223–31 . 2005 . 15769254 . 10.1042/BJ20042116 . 1184555 .
• Tajika Y, Matsuzaki T, Suzuki T, etal . Differential regulation of AQP2 trafficking in endosomes by microtubules and actin filaments . Histochem. Cell Biol. . 124 . 1 . 1–12 . 2006 . 16049696 . 10.1007/s00418-005-0010-3 . 14746792 .
• Patil VS, Sachdeva G, Modi DN, etal . Rab coupling protein (RCP): a novel target of progesterone action in primate endometrium . J. Mol. Endocrinol. . 35 . 2 . 357–72 . 2006 . 16216915 . 10.1677/jme.1.01807 . free .
• Jin M, Goldenring JR . The Rab11-FIP1/RCP gene codes for multiple protein transcripts related to the plasma membrane recycling system . Biochim. Biophys. Acta . 1759 . 6 . 281–95 . 2006 . 16920206 . 10.1016/j.bbaexp.2006.06.001 .
• Beausoleil SA, Villén J, Gerber SA, etal . A probability-based approach for high-throughput protein phosphorylation analysis and site localization . Nat. Biotechnol. . 24 . 10 . 1285–92 . 2006 . 16964243 . 10.1038/nbt1240 . 14294292 .
• Olsen JV, Blagoev B, Gnad F, etal . Global, in vivo, and site-specific phosphorylation dynamics in signaling networks . Cell . 127 . 3 . 635–48 . 2006 . 17081983 . 10.1016/j.cell.2006.09.026 . 7827573 . free .
• Ewing RM, Chu P, Elisma F, etal . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 1. 89 . 2007 . 17353931 . 10.1038/msb4100134 . 1847948 .

Notes and References

1. Lindsay AJ, Hendrick AG, Cantalupo G, Senic-Matuglia F, Goud B, Bucci C, McCaffrey MW . Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein . J Biol Chem . 277 . 14 . 12190–9 . Apr 2002 . 11786538 . 10.1074/jbc.M108665200 . free .
2. Hales CM, Griner R, Hobdy-Henderson KC, Dorn MC, Hardy D, Kumar R, Navarre J, Chan EK, Lapierre LA, Goldenring JR . Identification and characterization of a family of Rab11-interacting proteins . J Biol Chem . 276 . 42 . 39067–75 . Oct 2001 . 11495908 . 10.1074/jbc.M104831200 . free .
3. Web site: Entrez Gene: RAB11FIP1 RAB11 family interacting protein 1 (class I).
4. Carson. Brian P.. Maria Del Bas. Josep. Moreno-Navarrete. Jose Maria. Fernandez-Real. Jose Manuel. Mora. Silvia. The Rab11 Effector Protein FIP1 Regulates Adiponectin. PLOS ONE. September 2013. 8. 9. e74687. 10.1371/journal.pone.0074687. 24040321. 3770573. free.
5. Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Mol. Syst. Biol. . 3 . 89 . 2007 . 17353931 . 1847948 . 10.1038/msb4100134 .