RAB11A explained
Ras-related protein Rab-11A is a protein that in humans is encoded by the RAB11A gene.[1] [2]
Function
The protein encoded by this gene belongs to the small GTPase superfamily, Rab family. It is associated with both constitutive and regulated secretory pathways, and may be involved in protein transport.[3]
Rab-11a controls intracellular trafficking of the innate immune receptor TLR4, and thereby also receptor signaling[4]
Interactions
RAB11A has been shown to interact with:
Further reading
- Sakurada K, Uchida K, Yamaguchi K, Aisaka K, Ito S, Ohmori T, Takeyama Y, Ueda T, Hori Y, Ohyanagi H . Molecular cloning and characterization of a ras p21-like GTP-binding protein (24KG) from rat liver . Biochemical and Biophysical Research Communications . 177 . 3 . 1224–32 . June 1991 . 1711847 . 10.1016/0006-291X(91)90672-T .
- Gromov P, Celis JE . Rab11a is modified in vivo by isoprenoid geranylgeranyl . Electrophoresis . 19 . 10 . 1803–7 . July 1998 . 9719562 . 10.1002/elps.1150191043 . 25570226 .
- Zeng J, Ren M, Gravotta D, De Lemos-Chiarandini C, Lui M, Erdjument-Bromage H, Tempst P, Xu G, Shen TH, Morimoto T, Adesnik M, Sabatini DD . Identification of a putative effector protein for rab11 that participates in transferrin recycling . Proceedings of the National Academy of Sciences of the United States of America . 96 . 6 . 2840–5 . March 1999 . 10077598 . 15856 . 10.1073/pnas.96.6.2840 . free . 1999PNAS...96.2840Z .
- Dumanchin C, Czech C, Campion D, Cuif MH, Poyot T, Martin C, Charbonnier F, Goud B, Pradier L, Frebourg T . Presenilins interact with Rab11, a small GTPase involved in the regulation of vesicular transport . Human Molecular Genetics . 8 . 7 . 1263–9 . July 1999 . 10369872 . 10.1093/hmg/8.7.1263 . free .
- Mammoto A, Ohtsuka T, Hotta I, Sasaki T, Takai Y . Rab11BP/Rabphilin-11, a downstream target of rab11 small G protein implicated in vesicle recycling . The Journal of Biological Chemistry . 274 . 36 . 25517–24 . September 1999 . 10464283 . 10.1074/jbc.274.36.25517 . free .
- Shisheva A, Chinni SR, DeMarco C . General role of GDP dissociation inhibitor 2 in membrane release of Rab proteins: modulations of its functional interactions by in vitro and in vivo structural modifications . Biochemistry . 38 . 36 . 11711–21 . September 1999 . 10512627 . 10.1021/bi990200r .
- Prekeris R, Klumperman J, Scheller RH . A Rab11/Rip11 protein complex regulates apical membrane trafficking via recycling endosomes . Molecular Cell . 6 . 6 . 1437–48 . December 2000 . 11163216 . 10.1016/S1097-2765(00)00140-4 . free .
- Lapierre LA, Kumar R, Hales CM, Navarre J, Bhartur SG, Burnette JO, Provance DW, Mercer JA, Bähler M, Goldenring JR . Myosin vb is associated with plasma membrane recycling systems . Molecular Biology of the Cell . 12 . 6 . 1843–57 . June 2001 . 11408590 . 37346 . 10.1091/mbc.12.6.1843 .
- Prekeris R, Davies JM, Scheller RH . Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins . The Journal of Biological Chemistry . 276 . 42 . 38966–70 . October 2001 . 11481332 . 10.1074/jbc.M106133200 . free .
- Hales CM, Griner R, Hobdy-Henderson KC, Dorn MC, Hardy D, Kumar R, Navarre J, Chan EK, Lapierre LA, Goldenring JR . Identification and characterization of a family of Rab11-interacting proteins . The Journal of Biological Chemistry . 276 . 42 . 39067–75 . October 2001 . 11495908 . 10.1074/jbc.M104831200 . free .
- Lindsay AJ, Hendrick AG, Cantalupo G, Senic-Matuglia F, Goud B, Bucci C, McCaffrey MW . Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein . The Journal of Biological Chemistry . 277 . 14 . 12190–9 . April 2002 . 11786538 . 10.1074/jbc.M108665200 . free .
- Lindsay AJ, McCaffrey MW . Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain . The Journal of Biological Chemistry . 277 . 30 . 27193–9 . July 2002 . 11994279 . 10.1074/jbc.M200757200 . free .
- Scales SJ, Hesser BA, Masuda ES, Scheller RH . Amisyn, a novel syntaxin-binding protein that may regulate SNARE complex assembly . The Journal of Biological Chemistry . 277 . 31 . 28271–9 . August 2002 . 12145319 . 10.1074/jbc.M204929200 . free .
- Band AM, Ali H, Vartiainen MK, Welti S, Lappalainen P, Olkkonen VM, Kuismanen E . Endogenous plasma membrane t-SNARE syntaxin 4 is present in rab11 positive endosomal membranes and associates with cortical actin cytoskeleton . FEBS Letters . 531 . 3 . 513–9 . November 2002 . 12435603 . 10.1016/S0014-5793(02)03605-0 . 24295732 . free .
- Roosterman D, Schmidlin F, Bunnett NW . Rab5a and rab11a mediate agonist-induced trafficking of protease-activated receptor 2 . American Journal of Physiology. Cell Physiology . 284 . 5 . C1319–29 . May 2003 . 12540381 . 10.1152/ajpcell.00540.2002 . 13263412 .
- Tani K, Shibata M, Kawase K, Kawashima H, Hatsuzawa K, Nagahama M, Tagaya M . Mapping of functional domains of gamma-SNAP . The Journal of Biological Chemistry . 278 . 15 . 13531–8 . April 2003 . 12554740 . 10.1074/jbc.M213205200 . free .
Notes and References
- Drivas GT, Shih A, Coutavas EE, D'Eustachio P, Rush MG . Identification and characterization of a human homolog of the Schizosaccharomyces pombe ras-like gene YPT-3 . Oncogene . 6 . 1 . 3–9 . January 1991 . 1704119 .
- Gromov PS, Celis JE, Hansen C, Tommerup N, Gromova I, Madsen P . Human rab11a: transcription, chromosome mapping and effect on the expression levels of host GTP-binding proteins . FEBS Letters . 429 . 3 . 359–64 . June 1998 . 9662449 . 10.1016/S0014-5793(98)00607-3 . free .
- Web site: Entrez Gene: RAB11A RAB11A, member RAS oncogene family.
- Husebye H, Aune MH, Stenvik J, Samstad E, Skjeldal F, Halaas O, Nilsen NJ, Stenmark H, Latz E, Lien E, Mollnes TE, Bakke O, Espevik T . The Rab11a GTPase controls Toll-like receptor 4-induced activation of interferon regulatory factor-3 on phagosomes . Immunity . 33 . 4 . 583–96 . October 2010 . 20933442 . 10.1016/j.immuni.2010.09.010 . 10733841 . free .
- Ewing RM, Chu P, Elisma F, Li H, Taylor P, Climie S, McBroom-Cerajewski L, Robinson MD, O'Connor L, Li M, Taylor R, Dharsee M, Ho Y, Heilbut A, Moore L, Zhang S, Ornatsky O, Bukhman YV, Ethier M, Sheng Y, Vasilescu J, Abu-Farha M, Lambert JP, Duewel HS, Stewart II, Kuehl B, Hogue K, Colwill K, Gladwish K, Muskat B, Kinach R, Adams SL, Moran MF, Morin GB, Topaloglou T, Figeys D . Large-scale mapping of human protein-protein interactions by mass spectrometry . Molecular Systems Biology . 3 . 89 . 17353931 . 1847948 . 10.1038/msb4100134 . 2007 .
- Lindsay AJ, Hendrick AG, Cantalupo G, Senic-Matuglia F, Goud B, Bucci C, McCaffrey MW . Rab coupling protein (RCP), a novel Rab4 and Rab11 effector protein . The Journal of Biological Chemistry . 277 . 14 . 12190–9 . April 2002 . 11786538 . 10.1074/jbc.M108665200 . free .
- Lindsay AJ, McCaffrey MW . Rab11-FIP2 functions in transferrin recycling and associates with endosomal membranes via its COOH-terminal domain . The Journal of Biological Chemistry . 277 . 30 . 27193–9 . July 2002 . 11994279 . 10.1074/jbc.M200757200 . free .
- Hales CM, Griner R, Hobdy-Henderson KC, Dorn MC, Hardy D, Kumar R, Navarre J, Chan EK, Lapierre LA, Goldenring JR . Identification and characterization of a family of Rab11-interacting proteins . The Journal of Biological Chemistry . 276 . 42 . 39067–75 . October 2001 . 11495908 . 10.1074/jbc.M104831200 . free .
- Prekeris R, Davies JM, Scheller RH . Identification of a novel Rab11/25 binding domain present in Eferin and Rip proteins . The Journal of Biological Chemistry . 276 . 42 . 38966–70 . October 2001 . 11481332 . 10.1074/jbc.M106133200 . free .
- Wallace DM, Lindsay AJ, Hendrick AG, McCaffrey MW . Rab11-FIP4 interacts with Rab11 in a GTP-dependent manner and its overexpression condenses the Rab11 positive compartment in HeLa cells . Biochemical and Biophysical Research Communications . 299 . 5 . 770–9 . December 2002 . 12470645 . 10.1016/s0006-291x(02)02720-1 .
- Prekeris R, Klumperman J, Scheller RH . A Rab11/Rip11 protein complex regulates apical membrane trafficking via recycling endosomes . Molecular Cell . 6 . 6 . 1437–48 . December 2000 . 11163216 . 10.1016/s1097-2765(00)00140-4 . free .
- Ramel. Damien. Wang. Xiaobo. Laflamme. Carl. Montell. Denise J.. Denise Montell. Emery. Gregory. March 2013. Rab11 regulates cell–cell communication during collective cell movements. Nature Cell Biology. en. 15. 3. 317–324. 10.1038/ncb2681. 1465-7392. 4006229. 23376974.