| Country: | ZAF |
| Type: | R |
| Route: | 65 |
| Maint: | MDPWRT |
| Map: | Map of the R65 (South Africa).svg |
| Length Km: | 90.3 |
| Direction A: | West |
| Terminus A: | near Ermelo |
| Junction: | in Amsterdam |
| Direction B: | East |
| Terminus B: | MR19 on the Swaziland border at Sandlane |
| Cities: | Ermelo, Amsterdam |
| Previous Type: | R |
| Previous Route: | 64 |
| Next Type: | R |
| Next Route: | 66 |
The R65 is a provincial route in Mpumalanga, South Africa that connects Ermelo with the Eswatini border at Sandlane, via Amsterdam.[1]
The R65 begins just north-east of the Ermelo town centre, at a junction with the N17 national route. It heads eastwards from the N17 junction for 73 kilometres to reach a junction with the R33 route in the town of Amsterdam. The R65 continues east-north-east for 17 kilometres to reach the Nerston Border Post, where it crosses into Eswatini and becomes the MR19 route. The border on the Eswatini side is named Sandlane.