| Country: | IRL |
| Type: | R |
| Image Notes: | Near the Cork–Waterford border |
| Route: | 627 |
| Length Km: | 27.0 |
| Terminus A: | R907 at Main Street, Midleton, County Cork |
| Terminus B: | R634 at Main Street, Tallow, County Waterford |
| Previous Type: | R |
| Previous Route: | 626 |
| Next Type: | R |
| Next Route: | 628 |
The R627 is a regional road between Midleton in County Cork and Tallow, County Waterford in Ireland. The route begins in the centre of Midleton and runs northeast for 27km (17miles) to Tallow. Most of the route is in County Cork.